How it Works

Every aspect of our human capability and subjective experience is mediated by physical processes in our brain and physiology. Different pathways (e.g., neurotransmission and cellular energy) work in harmony to give rise to related capabilities.

We started with the full set of subjective experiences and capabilities that collectively result in highly creative and productive flow states, and we then mapped all of the physiological pathways and process known to correlate to those capabilities. We then mapped the complex interactions between those processes to better understand the meta-regulatory system as a whole. Finally, we mapped all the nutrients and biochemical interventions known to positively and sustainably enhance any (and every) aspect of that metasystem, factoring for synergies between those nutrients and chemicals.

This product was developed to support and enhance every major physiological process involved in mediating productive flow states:

Applied Neuropsychopharmacology - receptors

Optimize Neurochemistry

Rather than driving specific end-chain neurochemicals in ways that could create imbalances in other parts of the system, or lead to down-regulation of endogenous processes and homeostasis, we focused on supporting the underlying pathways and processes that produce and regulate neurochemistry for balanced and sustainable effects.

Optimize Neural Structures

Beyond supporting real time neurochemistry, we had the goal of positively affecting the underlying regulatory structures themselves in ways that could produce even greater upregulation and lasting benefits beyond the active chemistry lifecycle. That involved working on supporting the following structural upregulation processes:

Applied Neuropsychopharmacology - neuroprotection

Neuroprotection

– Cerebral antioxidants
– Protection against excitotoxins
– Increased cerebral detoxification

Applied Neuropsychopharmacology - neurogenesis

Neurogenesis

– Upregulated neurotrophins (BDNF, NGF, etc)
– Stimulation of new neuron development increased grey matter density

Neuroplasticity

– Neural plasticity modulators
– Electrical signaling modulators
– RNA upregulation

Cerebral Blood Flow

– Microcapillary blood supply
– Cerebral perfusion agents
– Vasomodulators

Energy & Metabolic Support

– Protect existing mitochondria
– Upregulate efficiency of ATP production
– Support new mitochondrial development

Cell Membrane Integrity

– Cell wall fluidity & elasticity
– Cell nucleus & mitochondrial membrane structure
– Myelin nerve & axonal sheath support

Optimize Cellular Energy

From a bottom-up point of view, we are a very complex coordination-colony of tens of trillions of individual cells. The physical energy processes that fuel these cells are foundational to everything they/we do. Decreased energy production at a cellular level is one of the primary elements of aging. Supporting cellular energy is fundamental to all the higher level processes we care to enhance.

Endocrine Support

Along with the nervous system, the endocrine (hormone) system is a part of the body’s top-down regulatory system. The endocrine system has significant control over a long list of processes: energy and fat metabolism, immune function, inflammation, tissue synthesis, genetic transcription, sleep, pain modulation, cognition, and even general mood. Everyone who has experienced changes in hormones knows how profound an effect they can have on our subjective state. Supporting endocrine system regulation is a critical pillar of optimizing mental and emotional well being.

Supporting Systems

Individual neurochemicals are regulated by neural networks which are part of the overall connectome, which is a part of the nervous system as a whole, which in turn affects the entire body. Neurotransmitters are made from amino acids that are broken down from dietary proteins in the upper GI tract. A significant percentage of our total neurotransmitter synthesis happens through bacterial processes in our intestines. Inflammatory conditions anywhere in the body can create cytokine cascades that cross the blood-brain barrier and affect the nervous system. The entire human organism is profoundly and complexly interconnected. Optimizing neurological function requires optimizing the function of the supporting systems.

Inflammation and Immune system support

• Cytokine regulation
• Macrophage activation
• Cellular antioxidation

Metabolic support

• Nutrient conversion and chemical synthesis
• Digestion and catabolism processes
• Foundational biotransformation processes:
methylation, phosphorylation, sulfation,
acetylation, etc.

Bottom up regulatory systems

• Genetic transcription
• Epigenetic modulation
• Microbiomic regulation and communication