Nootropics, sometimes called “smart drugs”, are exploding into the market, as science has increased its mastery over how to optimize brain function. But as nootropic supplements try to address issues like brain fog, cognitive decline, memory, and focus, many customers are trying to separate genuine neuroscience from snake oils.

There are dozens of nootropic ingredients with considerable research showing they improve cognitive function. Other nootropic stack ingredients aren’t nootropics per se, but rather prime biochemistry for nootropic absorption and efficacy. But clinical trials are harder to come by, because the costs required to conduct them can run into the tens of millions of dollars. Still, some patented ingredients have managed to fund clinical evidence of their efficacy. Here are 5 patented ingredients which have the clinical evidence many customers seek when trying to find the best nootropic stack:

5. PURENERGY® which is a co-crystal that combines caffeine and pTeroPure®. The
co-crystal links the two molecules together which impacts the way our bodies utilize
the molecules individually — thus providing a true synergistic effect. It promotes
heart health by helping to maintain a healthy systolic and diastolic blood pressure
levels within normal ranges. It supports healthy metabolism and cellular aging with
powerful antioxidant activities.*

4. Bioperine has been clinically shown to significantly enhance the
bioavailability of supplemented nutrients through increased absorption.**

3. Cognizin, which is a proprietary form of citicoline clinically shown to support mental
energy, focus, attention, and recall. It provides vital nutrients that help the brain
generate electrical impulses, care for healthy brain cells, and protect neurons from
free radical damage.Cognizin helps maintain normal levels of acetylcholine, a
nutrient that regulates cognitive function. The brain requires tremendous amounts of
energy. Cognizin supports the healthy mitochondria activity required for sustained
mental effort, and it aids in the synthesis and maintenance of cell membranes.***

2. ActivAMP® which is extracted from Gynostemma pentaphyllum, an adaptogenic
herb containing a family of compounds which upregulate alarmins including sestrins,
which are produced during exercise. The sestrins activate an enzyme called
AMP-activated protein kinase (AMPk). AMPk is often called the “master metabolic
regulator” and switches on the same fat-burning and energy producing metabolic
processes as exercise. By regulating metabolic activity (in the liver, lipids, skeletal
muscle and brain), AMPk influences glucose utilization, oxidation, and appetite.****

1. BioPQQ which improves memory, spatial awareness, and attention span by
facilitating nerve regeneration and enhancing nerve growth factor (a protein that
promotes the growth, maintenance, and survival of nerve cells). It helps
mitochondria increase in numbers and efficiency which in turn increases the
efficiency of brain cell function. The increased synthesis of mitochondria is caused by
the activation of two proteins that regulate the expression of genes and the formation
of mitochondria: cAMP response element-binding protein (CREB) and peroxisome
proliferator-activated receptor-coactivator-1 (PGC-1).*****

All 5 ingredients are in Qualia by Neurohacker Collective along with 37 additional ingredients which each play a role in maximizing overall cognitive benefit. Below, Neurohacker Collective co-founder Daniel Schmachtenberger explains the science behind the complex formula.

Below are links to the clinical efficacy of the 5 patented ingredients.

Learn more about the science behind Qualia, at

* PureEnergy
** BioPerine
*** Cognizin
**** ActivAMP
***** BioPQQ