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Bacopa monnieri Leaf Extract

Overview:
Studies indicate that Bacopa monnieri has neuroprotective, nootropic and adaptogenic effects. Research shows that it can improve memory formation and recall.

Scientific Name:
Bacopa monnieri

Mechanisms:

  • Bacosides are the active ingredients in Bacopa monnieri[1]
  • Inhibits acetylcholinesterase, activates choline acetyltransferase – increased levels of acetylcholine[1]
  • Increases neurite branching and proliferation – improves synaptic communication and memory[1]
  • Modulates the dopaminergic and serotonergic systems – mood enhancer[3]
  • Modulates the levels of superoxide dismutase (SOD) and oxidative damage from metals in the brain – protective against neurodegeneration[4]
  • Anxiolytic and analgesic effects[5,6]
  • Reduce the levels of the stress marker HSP70 in the brain – adaptogenic effect[7]
  • Synergistic with curcumin and EGCG[8]
References

[1] Aguiar S, Borowski T (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res, 16(4):313-26. doi: 10.1089/rej.2013.1431
[2] Sivaramakrishna, C, et al (2005). Triterpenoid glycosides from Bacopa monnieri. Phytochemistry, 66: 2719–2728. doi: 10.1016/j.phytochem.2005.09.016
[3] Rauf K, et al (2012). Effect of acute and sub-chronic use of Bacopa monnieri on dopamine and serotonin turnover in mice whole brain. AJPP. 2012;6:2767–2774. doi: 10.5897/AJPP12.244
[4] Chowdhuri DK, et al (2002). Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res, 16(7):639-45. doi: 10.1002/ptr.1023
[5] Chatterjee M, et al (2010). Comparative evaluation of Bacopa monniera and Panax quniquefolium in experimental anxiety and depressive models in mice. Indian J Exp Biol, 48(3):306-13. PMID: 21046986
[6] Bhaskar M, Jagtap AG (2011). Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monniera. Int J Ayurveda Res, 2(1):2-7. doi: 10.4103/0974-7788.83173
[7] Anbarasi K, et al (2006). Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: Modulation by bacoside A. Neuroscience, 138(4):1127-35. doi: 10.1016/j.neuroscience.2005.11.029
[8] Velmurugan K, et al (2009). Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic Biol Med, 46(3):430-40. doi: 10.1016/j.freeradbiomed.2008.10.050