Piperine is an alkaloid found in black pepper (Piper nigrum) with anti-inflammatory and nootropic effects. Piperine can boost memory and focus and improve executive function.

Scientific Name:
Pentadienoyl-2-piperidine from Piper nigrum


  • Increases the absorption and bioavailability of a number of nutrients, including vitamin C, vitamin B6 and EGCG[1]
  • Highly synergistic with curcumin – enhances its bioavailability and its anti-inflammatory effects[2]
  • Increases serotonin and dopamine levels [3]
  • Analgesic properties – activates TRPV1 ion channels on nociceptive (pain-sensing) neurons[4]
  • Increases motivation, attention and reasoning skills – productivity enhancer[5]

[1] Lambert JD, et al (2004). Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr, 134(8):1948-52. PMID: 15284381
[2] Shoba G, et al (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med, 64(4):353-6. doi: 10.1055/s-2006-957450
[3] Li S, et al (2007). Antidepressant-like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res, 9(3-5):421-30. PMID: 17701559
[4] McNamara FN, et al (2005). Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol, 144(6):781-90. doi: 10.1038/sj.bjp.0706040
[5] Wattanathorn J, et al (2008). Piperine, the potential functional food for mood and cognitive disorders. Food Chem Toxicol, 46(9):3106-10. doi: 10.1016/j.fct.2008.06.014