Cognizin Citicoline

Overview:
CDP Choline is a compound made up of choline and cytidine with neuroprotective and nootropic activity. CDP Choline decreases age-related memory impairment and cognitive decline, and enhances attention, learning and memory.

Scientific Name:
Cytidine diphosphocholine

Mechanisms:

  • After ingestion, CDP Choline originates choline and cytidine, the latter then being converted into uridine[1]
  • Both choline and uridine are neuroprotective[1]
  • Choline is a nicotinic Acetylcholine receptor agonist[2]
  • Increases the production of acetylcholine, adrenalin and noradrenalin[1]
  • Increases the release of Dopamine by acting on dopamine transporters[3]
  • Increases phosphatidylcholine production in the brain – an important component of cell membranes[4]
  • Maintains neuronal membrane integrity and reduces neuronal death[4,5]
References

[1] Weiss GB1 (1995). Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci. 1995;56(9):637-60. doi: 10.1016/0024-3205(94)00427-T
[2] Levin ED (2013). Complex relationships of nicotinic receptor actions and cognitive functions. Biochem Pharmacol, 86(8):1145-52. doi: 10.1016/j.bcp.2013.07.021
[3] Tayebati SK, et al (2013). Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS Neurol Disord Drug Targets, 12(1):94-103. doi: 10.2174/1871527311312010015
[4] Fagone P & Jackowski S (2012). Phosphatidylcholine and the CDP-choline cycle. Biochim Biophys Acta, 1831(3):523-32. doi: 10.1016/j.bbalip.2012.09.009
[5] Dempsey RJ & Raghavendra Rao VL (2003). Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats. J Neurosurg, 98(4):867-73. doi: 10.3171/jns.2003.98.4.0867