American Ginseng (Panax quinquefolius) Root Extract

American ginseng (Panax quinquefolius) is a variety of ginseng native to forested regions in North America. It is the same genus as Asian ginseng (Panax ginseng) and prized for many of the same reasons—invigorating and fortifying in times of higher stress or greater demands, and for supporting the capacity for mental and physical work. Both American and Asian ginseng contain similar active constituents called ginsenosides. The ginsenosides are thought to be responsible for many of the adaptogenic (i.e., stress and fatigue support) and health-promoting properties associated with ginseng [1]. While there are many different ginsenosides, the most well characterized include Rb1, Rb2, Rg1, Rc, Rd, and Re. 

TOP BENEFITS OF AMERICAN GINSENG

Supports brain health and cognitive performance*

Supports adaptation to stress *

Supports mood*

NEUROHACKER’S AMERICAN GINSENG SOURCING

American Ginseng Root Extract is standardized for 5% ginsenosides.

American Ginseng Root Extract is non-GMO, gluten-free, and vegan.

AMERICAN GINSENG FORMULATING PRINCIPLES AND RATIONALE

We consider Panax quinquefolius to be in the adaptogenic herb category; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected a serving that is consistent with those used in human clinical studies for supporting working memory, alertness, and calmness.*

AMERICAN GINSENG KEY MECHANISMS

Supports brain function and cognition*

Supports attention* [2]

Supports working memory* [2,3]

Supports learning and memory (in animals)* [4–7]

Supports cholinergic neurotransmission* [1,4,5,8,9]

Supports dopaminergic neurotransmission* [10–13]

Supports GABAergic neurotransmission* [1,14]

Supports neurite outgrowth, dendritic spine density, and synaptic plasticity* [1,5–7]

Supports BDNF signaling* [1,7,8,15]

Supports neurogenesis (in animals)* [1,8,15] 

Supports neuroprotective functions* [1,4,5,8,14,16]

Supports antioxidant defenses and counters oxidative stress* [14]

Supports healthy neural immune/cytokine signaling* [1,8,14,17]

Supports mood*

Supports calmness* [2]

Supports mood* [1,14,18]

Adaptogenic actions (i.e., supports stress resilience and anti-fatigue)* [5]

Modulates stress hormone levels / HPA-axis activation* [1,14] 

Supports healthy cardiometabolic function*

Supports healthy cardiometabolic parameters* [19–21]

Supports healthy blood glucose levels* [22–24]

Supports fat metabolism* [21]

Supports mitochondrial enzyme complex activities* [14]

Supports a healthy gut microbiota*

Supports healthy gut microbiota composition* [25–27]

Supports healthy gut immune/cytokine signaling* [25,26,28]

Supports gut-brain axis* [29]

Supports exercise performance*

Supports high-intensity endurance performance* [30,31]

Supports healthy responses to exercise-induced muscle damage* [30–32]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES 

[1]H.J. Kim, P. Kim, C.Y. Shin, J. Ginseng Res. 37 (2013) 8–29.

[2]A. Scholey, A. Ossoukhova, L. Owen, A. Ibarra, A. Pipingas, K. He, M. Roller, C. Stough, Psychopharmacology 212 (2010) 345–356.

[3]A. Ossoukhova, L. Owen, K. Savage, M. Meyer, A. Ibarra, M. Roller, A. Pipingas, K. Wesnes, A. Scholey, Hum. Psychopharmacol. 30 (2015) 108–122.

[4]K. Shin, H. Guo, Y. Cha, Y.-H. Ban, D.W. Seo, Y. Choi, T.-S. Kim, S.-P. Lee, J.-C. Kim, E.-K. Choi, J.-M. Yon, Y.-B. Kim, Regul. Toxicol. Pharmacol. 78 (2016) 53–58.

[5]Y. Cheng, L.-H. Shen, J.-T. Zhang, Acta Pharmacol. Sin. 26 (2005) 143–149.

[6]I. Mook-Jung, H.S. Hong, J.H. Boo, K.H. Lee, S.H. Yun, M.Y. Cheong, I. Joo, K. Huh, M.W. Jung, J. Neurosci. Res. 63 (2001) 509–515.

[7]H. Zhao, Q. Li, X. Pei, Z. Zhang, R. Yang, J. Wang, Y. Li, Behav. Brain Res. 201 (2009) 311–317.

[8]K. Radad, R. Moldzio, W.-D. Rausch, CNS Neurosci. Ther. 17 (2011) 761–768.

[9]C.G. Benishin, Neurochem. Int. 21 (1992) 1–5.

[10]G.-L. Wang, Y.-P. Wang, J.-Y. Zheng, L.-X. Zhang, Brain Res. 1699 (2018) 44–53.

[11]S.H. Lee, J. Hur, E.H. Lee, S.Y. Kim, Biomol. Ther. 20 (2012) 482–486.

[12]H.S. Kim, Y.T. Hong, K.W. Oh, Y.H. Seong, H.M. Rheu, D.H. Cho, S. Oh, W.K. Park, C.G. Jang, Gen. Pharmacol. 30 (1998) 783–789.

[13]H.S. Kim, K.S. Kim, K.W. Oh, Pharmacol. Biochem. Behav. 63 (1999) 407–412.

[14]P. Chanana, A. Kumar, Front. Neurosci. 10 (2016) 84.

[15]L.-H. Shen, J.-T. Zhang, Neurol. Res. 26 (2004) 422–428.

[16]Y.C. Kim, S.R. Kim, G.J. Markelonis, T.H. Oh, J. Neurosci. Res. 53 (1998) 426–432.

[17]C.F. Wu, X.L. Bi, J.Y. Yang, J.Y. Zhan, Y.X. Dong, J.H. Wang, J.M. Wang, R. Zhang, X. Li, Int. Immunopharmacol. 7 (2007) 313–320.

[18]M. Chatterjee, P. Verma, G. Palit, Indian J. Exp. Biol. 48 (2010) 306–313.

[19]I. Mucalo, E. Jovanovski, D. Rahelić, V. Božikov, Z. Romić, V. Vuksan, J. Ethnopharmacol. 150 (2013) 148–153.

[20]V. Vuksan, Z.Z. Xu, E. Jovanovski, A.L. Jenkins, U. Beljan-Zdravkovic, J.L. Sievenpiper, P. Mark Stavro, A. Zurbau, L. Duvnjak, M.Z.C. Li, Eur. J. Nutr. (2018).

[21]R.K. Singh, E. Lui, D. Wright, A. Taylor, M. Bakovic, Can. J. Physiol. Pharmacol. 95 (2017) 1046–1057.

[22]V. Vuksan, M.P. Stavro, J.L. Sievenpiper, V.Y. Koo, E. Wong, U. Beljan-Zdravkovic, T. Francis, A.L. Jenkins, L.A. Leiter, R.G. Josse, Z. Xu, J. Am. Coll. Nutr. 19 (2000) 738–744.

[23]V. Vuksan, J.L. Sievenpiper, V.Y. Koo, T. Francis, U. Beljan-Zdravkovic, Z. Xu, E. Vidgen, Arch. Intern. Med. 160 (2000) 1009–1013.

[24]V. Vuksan, J.L. Sievenpiper, J. Wong, Z. Xu, U. Beljan-Zdravkovic, J.T. Arnason, V. Assinewe, M.P. Stavro, A.L. Jenkins, L.A. Leiter, T. Francis, Am. J. Clin. Nutr. 73 (2001) 753–758.

[25]C.-Z. Wang, C. Yu, X.-D. Wen, L. Chen, C.-F. Zhang, T. Calway, Y. Qiu, Y. Wang, Z. Zhang, S. Anderson, Y. Wang, W. Jia, C.-S. Yuan, Cancer Prev. Res. 9 (2016) 803–811.

[26]C.-Z. Wang, W.-H. Huang, C.-F. Zhang, J.-Y. Wan, Y. Wang, C. Yu, S. Williams, T.-C. He, W. Du, M.W. Musch, E.B. Chang, C.-S. Yuan, Clin. Transl. Oncol. 20 (2018) 302–312.

[27]R. Zhou, D. He, J. Xie, Q. Zhou, H. Zeng, H. Li, L. Huang, Front. Immunol. 12 (2021) 665901.

[28]C.-Z. Wang, H. Yao, C.-F. Zhang, L. Chen, J.-Y. Wan, W.-H. Huang, J. Zeng, Q.-H. Zhang, Z. Liu, J. Yuan, Y. Bi, C. Sava-Segal, W. Du, M. Xu, C.-S. Yuan, Int. Immunopharmacol. 64 (2018) 246–251.

[29]C.S. Yuan, X. Wang, J.A. Wu, A.S. Attele, J.T. Xie, M. Gu, Phytomedicine 8 (2001) 178–183.

[30]C.-W. Hou, S.-D. Lee, C.-L. Kao, I.-S. Cheng, Y.-N. Lin, S.-J. Chuang, C.-Y. Chen, J.L. Ivy, C.-Y. Huang, C.-H. Kuo, PLoS One 10 (2015) e0116387.

[31]J. Wu, S. Saovieng, I.-S. Cheng, T. Liu, S. Hong, C.-Y. Lin, I.-C. Su, C.-Y. Huang, C.-H. Kuo, J. Ginseng Res. (2018).

[32]M. Estaki, E.G. Noble, Appl. Physiol. Nutr. Metab. 40 (2015) 116–121.