Amla (Emblica officinalis) Fruit Extract

Amla (Emblica officinalis) Fruit Extract COMMON NAME

Amla | Emblic | Indian Gooseberry | Amalaki | Emblic Myrobalan


TOP BENEFITS OF AMLA FRUIT

Supports healthy vision *

Supports brain health *

Supports healthy aging *

Supports maintenance of cardiovascular health *

Supports metabolic health *

Support healthy skin *


WHAT IS AMLA FRUIT?

Amla (the fruit from Phyllanthus emblica L. or Emblica officinalis Gaertn.) is one of the most important fruits in Ayurveda and in traditional healing systems in other parts of South and Southeast Asia. The name Amla derives from the Sanskrit word Amalaki, which means the “fruit of heaven”—the fruit was revered in both Hinduism and Buddhism. In Ayurveda, Amla is classified as a rasayana (i.e., a rejuvenator used for healthy aging), and is a tonic for Alochaka Pitta, which governs eyesight and is responsible for sight and thinking process, enabling us to see, perceive and analyse objects. Amla is used by itself, but also very commonly used as a core part of many poly-ingredient herbal combinations, such as Triphala (“three fruits”), which combines amla with two other types of myrobalan fruits. The most widely used part of the plant is the fruit, which has many health benefits due to its antioxidant and immunomodulatory activities. Its main bioactive compounds include tannins, alkaloids, polyphenols, minerals, and vitamins, including high levels of vitamin C. The high tannin content gives the fruit a sour and astringent taste. Amla fruit is the primary eye tonic medicine in Ayurveda. In traditional use, it was believed to preserve eyesight and relieve complaints related to eye strain and fatigue [1–3].*  


NEUROHACKER’S AMLA FRUIT SOURCING

Amla Fruit Extract is standardized for ≥45% tannins, ≥10% gallic acid, and ≥1% vitamin C.

Amla Fruit Extract is produced by Verdure Sciences®, a supplier of botanical extracts with an emphasis on developing scientifically-backed botanical extracts through clinical initiatives.* Verdure Sciences® values responsible and ethically sourced products. 

Amla Fruit Extract is non-GMO and vegan.


AMLA FRUIT DOSING PRINCIPLES AND RATIONALE

Since Amla is a Rasayana, we'd consider it to have adaptogen characteristics and follow hormetic dosing principles (see Neurohacker Dosing Principles) with the dose selected being within a range. In clinical studies, Amla fruit extracts have most commonly been used at doses of 250 mg and 500 mg, often taken twice daily [4–10]. When used in combination with other fruits or herbs, standardized Amla extracts have been used at lower doses—doses as low as 60 mg have been used [11]. Since we’re using a standardized Amla fruit extract combined with other fruits and herb extracts, we chose a dose to be consistent with the lower dose range more typically used in combination ingredient studies.*


AMLA FRUIT KEY MECHANISMS

Vision Support*
Supports maintenance of lens health and function [12–14]
Supports maintenance of healthy retinal function [15]
Supports retinal and lens antioxidant defenses  [12,15]
Supports retinal mitochondrial function [15]


Brain function*
Supports neuroprotective functions [16–22]
Supports cholinergic neurotransmission [19,21]
Supports brain mitochondrial function [23]


Healthy aging and longevity* 
Supports maintenance of cardiovascular health [4,5,7,8,24,25]
Supports metabolic health [26]
Supports antioxidant defenses [4,5,27]
Promotes healthy cellular stress responses [28]
Supports DNA repair [29]
Supports telomerase activity and telomere length [30]


Skin*
Supports healthy skin structure [11]
Supports dermal skin cell (fibroblast) proliferation [31]
Supports dermal extracellular matrix (ECM) structure (collagen, hyaluronic acid) [31–35]
Supports skin antioxidant defenses [32,35,36]
Supports skin defenses against environmental stress [33,35]


REFERENCES

[1]S.S. Yadav, M.K. Singh, P.K. Singh, V. Kumar, Biomed. Pharmacother. 93 (2017) 1292–1302.

[2]B.C. Variya, A.K. Bakrania, S.S. Patel, Pharmacol. Res. 111 (2016) 180–200.

[3]S. Dasaroju, K.M. Gottumukkala, Int J Pharm Sci Rev Res 24 (2014) 150–159.

[4]P. Usharani, P.L. Merugu, C. Nutalapati, BMC Complement. Altern. Med. 19 (2019) 97.

[5]N. Fatima, P. Usharani, Muralidhar, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (2013) 275.

[6]S.K. Varnosfaderani, F. Hashem-Dabaghian, G. Amin, M. Bozorgi, G. Heydarirad, E. Nazem, M.N. Toosi, S.H. Mosavat, Journal of Integrative Medicine 16 (2018) 126–131.

[7]H. Upadya, S. Prabhu, A. Prasad, D. Subramanian, S. Gupta, A. Goel, BMC Complement. Altern. Med. 19 (2019) 27.

[8]N. Fatima, U. Pingali, R. Pilli, Pharmacognosy Res. 6 (2014) 29–35.

[9]R. Colucci, F. Dragoni, R. Conti, L. Pisaneschi, L. Lazzeri, S. Moretti, Dermatologic Therapy 28 (2015) 17–21.

[10]D. Shanmugarajan, C. Girish, N. Harivenkatesh, B. Chanaveerappa, N.C. Prasanna Lakshmi, Phytother. Res. 35 (2021) 3275–3285.

[11]T. Uchiyama, M. Tsunenaga, M. Miyanaga, O. Ueda, M. Ogo, Biotechnol. Appl. Biochem. 66 (2019) 870–879.

[12]N. Kavitha Nair, K. Patel, T. Gandhi, Iran J Pharm Res 9 (2010) 147–152.

[13]J. Banot, G. Lata, O.P. Jangir, M. Sharma, V.S. Rathore, S.K. Saini, A. Nagal, Indian J. Exp. Biol. 47 (2009) 157–162.

[14]P. Suryanarayana, P.A. Kumar, M. Saraswat, J.M. Petrash, G.B. Reddy, Mol. Vis. 10 (2004) 148–154.

[15]S. Nashine, R. Kanodia, A.B. Nesburn, G. Soman, B.D. Kuppermann, M.C. Kenney, Aging 11 (2019) 1177–1188.

[16]I. Husain, S. Zameer, T. Madaan, A. Minhaj, W. Ahmad, A. Iqubaal, A. Ali, A.K. Najmi, Metab. Brain Dis. 34 (2019) 957–965.

[17]M. Golechha, J. Bhatia, D.S. Arya, Indian J. Exp. Biol. 48 (2010) 474–478.

[18]M. Golechha, J. Bhatia, S. Ojha, D.S. Arya, Pharm. Biol. 49 (2011) 1128–1136.

[19]M. Golechha, J. Bhatia, D.S. Arya, J. Environ. Biol. 33 (2012) 95–100.

[20]A. Justin Thenmozhi, M. Dhivyabharathi, T.R. William Raja, T. Manivasagam, M.M. Essa, Nutr. Neurosci. 19 (2016) 269–278.

[21]M.S. Uddin, A.A. Mamun, M.S. Hossain, F. Akter, M.A. Iqbal, M. Asaduzzaman, Ann Neurosci 23 (2016) 218–229.

[22]A. Bhattacharya, S. Ghosal, S.K. Bhattacharya, Indian J. Exp. Biol. 38 (2000) 877–880.

[23]V.D. Reddy, P. Padmavathi, G. Kavitha, S. Gopi, N. Varadacharyulu, J. Med. Food 14 (2011) 62–68.

[24]S. Khanna, A. Das, J. Spieldenner, C. Rink, S. Roy, J. Med. Food 18 (2015) 415–420.

[25]F. Hashem-Dabaghian, M. Ziaee, S. Ghaffari, F. Nabati, S. Kianbakht, J Cardiovasc Thorac Res 10 (2018) 118–128.

[26]M.S. Akhtar, A. Ramzan, A. Ali, M. Ahmad, Int. J. Food Sci. Nutr. 62 (2011) 609–616.

[27]T. Yokozawa, H.Y. Kim, H.J. Kim, T. Okubo, D.-C. Chu, L.R. Juneja, Br. J. Nutr. 97 (2007) 1187–1195.

[28]V. Dwivedi, S.C. Lakhotia, J. Biosci. 41 (2016) 697–711.

[29]U. Vishwanatha, K.P. Guruprasad, P.M. Gopinath, R.V. Acharya, B.V. Prasanna, J. Nayak, R. Ganesh, J. Rao, R. Shree, S. Anchan, K.S. Raghu, M.B. Joshi, P. Paladhi, P.M. Varier, K. Muraleedharan, T.S. Muraleedharan, K. Satyamoorthy, J. Ethnopharmacol. 191 (2016) 387–397.

[30]K.P. Guruprasad, S. Dash, M.B. Shivakumar, P.R. Shetty, K.S. Raghu, B.R. Shamprasad, V. Udupi, R.V. Acharya, P.B. Vidya, J. Nayak, A.E. Mana, R. Moni, M.T. Sankaran, K. Satyamoorthy, J. Ayurveda Integr. Med. 8 (2017) 105–112.

[31]T. Fujii, M. Wakaizumi, T. Ikami, M. Saito, J. Ethnopharmacol. 119 (2008) 53–57.

[32]S. Pientaweeratch, V. Panapisal, A. Tansirikongkol, Pharm. Biol. 54 (2016) 1865–1872.

[33]M.D. Adil, P. Kaiser, N.K. Satti, A.M. Zargar, R.A. Vishwakarma, S.A. Tasduq, J. Ethnopharmacol. 132 (2010) 109–114.

[34]P. Chanvorachote, V. Pongrakhananon, S. Luanpitpong, B. Chanvorachote, S. Wannachaiyasit, U. Nimmannit, J. Cosmet. Sci. 60 (2009) 395–403.

[35]M. Majeed, B. Bhat, S. Anand, A. Sivakumar, P. Paliwal, K.G. Geetha, J. Cosmet. Sci. 62 (2011) 49–56.

[36]R.K. Chaudhuri, Skin Pharmacol. Appl. Skin Physiol. 15 (2002) 374–380.