Benfotiamine is a lipid derivative of thiamine (vitamin B1). Unlike the commonly used forms of vitamin B1 used in dietary supplements (thiamine HCL) and food fortification (thiamine mononitrate), which are water-soluble, benfotiamine is fat-soluble (i.e., dissolves in fat). This makes it more bioavailable, which results in higher levels of thiamine in peripheral tissues such as muscle, brain, liver, and kidney.(1) In these and other peripheral tissues, benfotiamine has the same functions as other sources of thiamine. These include playing a central role in the metabolism of sugars, proteins, and fats, and is instrumental in several important processes needed to make cellular energy.
Benfotiamine is a fat-soluble derivative of vitamin B1 (thiamine). It can produce higher tissue levels of thiamine in peripheral tissues than water-soluble forms of thiamine.(2)
Benfotiamine is additive with Thiamine—both have vitamin B1 activity. But, because of FDA labeling regulations, benfotiamine can not be listed on labels as having a daily value or contributing to vitamin B1 activity.
Benfotiamine sourcing is focused on identifying and purchasing from a reputable supplier and ensuring the benfotiamine is NON-GMO, gluten-free and vegan.
In general, we use a dose of benfotiamine that’s been shown to support metabolism of sugars through the key pathways where thiamine activity is critical (glycolysis and pentose phosphate pathway). This doses provides substantial thiamine activity in peripheral tissues. In general, benfotiamine has increased vitamin B1 activity in peripheral tissues like the brain, heart, liver, and muscles, but wouldn’t be expected to have as much activity in the stomach or intestines. If our formulation targets brain function, we don’t combine benfotiamine with thiamine HCL. If our formulation’s goal is to support all tissues (including stomach and intestines) we combine a small amount of thiamine HCL with benfotiamine. This captures the increased bioavailability in peripheral tissues that benfotiamine offers, while also getting the stomach/intestine vitamin B1 support from the thiamine HCL.
Cofactor in the pyruvate dehydrogenase complex
Cofactor in the citric acid cycle
Cofactor in the pentose phosphate pathway
Protection of organs and systems
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.