Celastrus | Intellect Tree | Jyotishmati
Supports cognitive performance*
Supports mood*
Supports stress response*
Celastrus paniculatus is native to India, where itβs used by local healers primarily as a brain tonic for reasons that are consistent with one of its common names, βthe intellect tree.β Today weβd recognize these uses as offering nootropic support. These uses include β...mental acuity, support memory and intellect as well as retention and recalling power; and to alleviate mental fatigue, stress...β*[1] It was believed that people using this plant would be able to learn new information more quickly, and more accurately and efficiently recall it later.*[1] Celastrus paniculatus seeds (and their oil) are what is used for cognitive support. The seeds contains a variety of active compounds, including sesquiterpenes such as celastrine, celapanine, celapanigine, celapagin, malkangunin and paniculatine. Celastrus paniculatus extracts have, in experimental research, positively influenced cognitive function and neuroprotective functions.*
Celastrus paniculatus is an alcohol extract of the seeds.
Grown in India.
Celastrus paniculatus is non-GMO, gluten-free, and vegan.
One way Celastrus paniculatus was traditionally used was to have a person start by eating one seed a day in the diet, and then gradually increase by one seed a day, up to a maximum of 100 seeds daily.[1] This suggests to Neurohacker that the best way to approach dosing would be to consider Celastrus paniculatus as an adaptogenic herb; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected to dose this at a low-to-moderate amount because of both the traditional approach to use, and because of our N of 1 dosing experience in product development and testing.*
Supports brain function and cognition*
Supports memory and facilitates learning [2,5,7]
Counters experimentally-induced memory and learning impairments in animals [5,8β11]
Supports the levels of monoamine neurotransmitters (noradrenaline, dopamine and serotonin) and their metabolites in the brain [2]
Interacts with dopamine-D2, serotonergic, GABAB, and NMDA receptors [3,4]
Influences brain MAO-A levels [3]
Influences acetylcholinesterase activity in the brain [5]
Supports brain content of total lipids and phospholipids [6]
Supports neuroprotective functions [4,11,13,14]
Supports a healthy mood and stress response*
Supports positive behavioral responses to stress [3,8,12]
Influences plasma corticosterone (stress hormone) levels [3]
Supports antioxidant defenses*
Supports antioxidant defenses [7,11,13β17]
Counters oxidative stress [7,11,13β17]
Supports free-radical-scavenging activity [14,16,18]
Other actions*
Supports healthy immune/cytokine signaling [17,19,20]
Supports relief of minor physical discomfort [19,20]
Supports gastroprotective functions [17]
Supports healthy cholesterol levels [21]
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
REFERENCES
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[2]K. Nalini, K.S. Karanth, A. Rao, A.R. Aroor, J. Ethnopharmacol. 47 (1995) 101β108.
[3]R. Valecha, D. Dhingra, Basic Clin Neurosci 7 (2016) 49β56.
[4]P.B. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, J. Ethnopharmacol. 93 (2004) 213β219.
[5]M. Bhanumathy, M.S. Harish, H.N. Shivaprasad, G. Sushma, Pharm. Biol. 48 (2010) 324β327.
[6]P.P. Bidwai, D. Wangoo, N.K. Bhullar, J. Ethnopharmacol. 21 (1987) 307β314.
[7]M.H.V. Kumar, Y.K. Gupta, Phytomedicine 9 (2002) 302β311.
[8]V. Bhagya, T. Christofer, B.S. Shankaranarayana Rao, Indian J. Pharmacol. 48 (2016) 687β693.
[9]M. Gattu, K.L. Boss, A.V. Terry Jr, J.J. Buccafusco, Pharmacol. Biochem. Behav. 57 (1997) 793β799.
[10]S.B. Raut, R.R. Parekar, K.S. Jadhav, P.A. Marathe, N.N. Rege, Anc. Sci. Life 34 (2015) 130β133.
[11]J. Malik, M. Karan, R. Dogra, Pharm. Biol. 55 (2017) 980β990.
[12]R. Rajkumar, E.P. Kumar, S. Sudha, B. Suresh, Fitoterapia 78 (2007) 120β124.
[13]M. Chakrabarty, P. Bhat, S. Kumari, A. DβSouza, K.L. Bairy, A. Chaturvedi, A. Natarajan, M.K.G. Rao, S. Kamath, J. Pharmacol. Pharmacother. 3 (2012) 161β171.
[14]P.B. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, Phytomedicine 13 (2006) 29β36.
[15]G. Lekha, K. Mohan, I.A. Samy, Pharmacognosy Res. 2 (2010) 169β174.
[16]P. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, Fitoterapia 74 (2003) 658β669.
[17]S. Palle, A. Kanakalatha, C.N. Kavitha, J. Diet. Suppl. 15 (2018) 373β385.
[18]A. Russo, A.A. Izzo, V. Cardile, F. Borrelli, A. Vanella, Phytomedicine 8 (2001) 125β132.
[19]F. Ahmad, R.A. Khan, S. Rasheed, J. Ethnopharmacol. 42 (1994) 193β198.
[20]Y.A. Kulkarni, S. Agarwal, M.S. Garud, J. Ayurveda Integr. Med. 6 (2015) 82β88.
[21]R.H. Patil, K. Prakash, V.L. Maheshwari, Indian J. Clin. Biochem. 25 (2010) 405β410.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.