Cinnulin PF® Cinnamomum burmannii Bark Extract

Cinnamomum burmannii Bark Extract Common Name

Cinnamon | Indonesian Cassia

Top Benefits of Cinnamon Extract

  • Supports healthy aging*
  • Supports metabolic health*
  • Supports healthy weight*
  • Supports antioxidant defenses*
  • Supports cellular responses*
  • Supports healthy gut microbiota*
  • Supports healthy blood sugar levels*
  • Supports women’s hormone balance*
  • Supports healthy blood pressure*

What is Cinnamon Extract?

Cinnamon is one of the world's oldest spices. Along with pepper and ginger, it was a big part of the spice trade between Asia and Europe. Cinnamon comes from the inner bark of several different tree species from the genus Cinnamomum. The various species of the cinnamon tree are native to India, Sri Lanka, Indonesia, and Burma. While cinnamon species are similar, they don’t produce identical extracts. We opted for Cinnulin PF®—a standardized Cinnamomum burmannii bark extract—because (1) it has undergone human clinical trials, and (2) is monitored to contain not more than 0.7% coumarin, a compound that should only be consumed in low amounts. 

Neurohacker’s Cinnamon Extract Sourcing

Cinnulin PF® is a patented 20:1 water-soluble cinnamon extract from the bark of the Cinnamomum burmannii tree.

Clinically tested and shown to support normal blood sugar levels, insulin signaling pathways, healthy blood pressure, healthy body composition, and women’s hormone balance. *

Standardized to contain not less than 3% doubly linked type-A polymers and not more than 0.7% coumarin.

Produced using a proprietary extraction process called Controlled Polymer Purification Technology (CPPT). This process allows the important, biologically active compounds to be isolated and removes most of the potential toxins from the whole cinnamon.

Non-GMO, Vegan, Certified Kosher

Cinnamon Extract Dosing Principles and Rationale

A dose of 500 mg per day of Cinnulin PF® has been used in clinical trials. This dose, as a sole nutritional intervention, has supported healthy responses in a number of functional health areas. Since we are using the cinnamon extract as part of a stack with other ingredients, we anticipate there being some degree of additive responses. We also do not think cinnamon is a more is better ingredient. Like many plants, cinnamon contains compounds that appear to follow hormetic dosing principles (see Neurohacker Dosing Principles). When this is the case, especially if we intend a formulation to be used long-term, we prefer to be conservative with our dosing. Because of these intersecting principles, we decided to include half the studied dose of Cinnulin PF®.

Cinnamon Extract Key Mechanisms

Metabolism

  • Supports healthy insulin sensitivity (1–8)
  • Upregulates the insulin signaling pathway  (1, 3, 9)
  • Upregulates the glucose transporter GLUT-4 (10–12)
  • Downregulates fat accumulation and blood/liver lipid levels (1, 4, 7–9, 11, 13, 14)
  • Upregulates lean mass (15)
  • Upregulates adiponectin levels (1)

Signaling pathways

  • Upregulates AMP-activated protein kinase (AMPK) signaling (4, 10, 16)
  • Upregulates liver kinase B1 (LKB1)  (10)
  • Upregulates peroxisome proliferator-activated receptor alpha (PPARα) and delta (PPARδ); modulates PPAR gamma (PPARγ) (4, 11, 17)

Antioxidant defenses

  • Downregulates the production of reactive oxygen species and oxidative stress (13, 18, 19)
  • Upregulates antioxidant enzymes (superoxide dismutase [SOD]) (19)
  • Replenishes glutathione (GSH) levels (19)

Cellular signaling

  • Downregulates the expression of proinflammatory molecules (tumor necrosis factor alpha [TNFα], nuclear factor kappa B [NF-κB], interleukin 1β [IL-1β], IL-6) (3, 20, 21)
  • Protects mitochondrial structure and function (22, 23)

Gut microbiota

  • Regulates the composition of the gut microbiota (24, 25)
  • Supports gut barrier function (24)

Healthy aging and longevity 

  • Neuroprotective effects (26)
  • Supports liver function (11)
  • Upregulates heat-shock protein 70 (HSP70) (27)
  • Upregulates SIRT1, SIRT2, and SIRT3 (20, 21)
  • Upregulates uncoupling protein 1 (UCP1) (12, 14)
  • Extends lifespan (Drosophila melanogaster) (27)

REFERENCES

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5. M. Hajimonfarednejad et al., Phytother. Res. 32, 276–283 (2018).
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19. A. S. Sahib, J Intercult Ethnopharmacol. 5, 108–113 (2016).
20. B. Qin, K. S. Panickar, R. A. Anderson, Nutrition. 30, 210–217 (2014).
21. B. Qin, K. S. Panickar, R. A. Anderson, Life Sci. 102, 72–79 (2014).
22. K. Couturier et al., J. Nutr. Biochem. 28, 183–190 (2016).
23. K. S. Panickar, M. M. Polansky, R. A. Anderson, Exp. Neurol. 216, 420–427 (2009).
24. M. Van Hul et al., Am. J. Physiol. Endocrinol. Metab. 314, E334–E352 (2018).
25. Q.-Y. Lu et al., J. Food Sci. 82, 1807–1813 (2017).
26. D. W. Peterson et al., J. Alzheimers. Dis. 17, 585–597 (2009).
27. S. E. Schriner et al., Exp. Gerontol. 60, 220–230 (2014).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.