Cinnulin PF® Cinnamomum burmannii Bark Extract

Common Name

Cinnamon | Indonesian Cassia 

Top Benefits of Cinnulin PF®

Supports healthy aging*

Supports metabolic health*

Supports healthy weight*

Supports antioxidant defenses*

Supports cellular responses*

Supports healthy gut microbiota*

Supports healthy blood sugar levels*

Supports women’s hormone balance*

Supports healthy blood pressure*

What is Cinnulin PF®?

Cinnamon is one of the world's oldest spices. Along with pepper and ginger, it was a big part of the spice trade between Asia and Europe. Cinnamon comes from the inner bark of several different tree species from the genus Cinnamomum. The various species of the cinnamon tree are native to India, Sri Lanka, Indonesia, and Burma. While cinnamon species are similar, they don’t produce identical extracts. We opted for Cinnulin PF®—a standardized Cinnamomum burmannii bark extract—because (1) it has undergone human clinical trials, and (2) is monitored to contain not more than 0.7% coumarin, a compound that should only be consumed in low amounts. ´

Neurohacker’s Cinnulin PF® Sourcing

Cinnulin PF® is a patented 20:1 water-soluble cinnamon extract from the bark of the Cinnamomum burmannii tree.

Clinically tested and shown to support normal blood sugar levels, insulin signaling pathways, healthy blood pressure, healthy body composition, and women’s hormone balance. *

Standardized to contain not less than 3% doubly linked type-A polymers and not more than 0.7% coumarin.

Produced using a proprietary extraction process called Controlled Polymer Purification Technology (CPPT). This process allows the important, biologically active compounds to be isolated and removes most of the potential toxins from the whole cinnamon.

Non-GMO, Vegan, Certified Kosher.

Cinnulin PF® Dosing Principles and Rationale

A dose of 500 mg per day of Cinnulin PF® has been used in clinical trials. This dose, as a sole nutritional intervention, has supported healthy responses in a number of functional health areas. Since we are using the cinnamon extract as part of a stack with other ingredients, we anticipate there being some degree of additive responses. We also do not think cinnamon is a more is better ingredient. Like many plants, cinnamon contains compounds that appear to follow hormetic dosing principles (see Neurohacker Dosing Principles). When this is the case, especially if we intend a formulation to be used long-term, we prefer to be conservative with our dosing. Because of these intersecting principles, we decided to include half the studied dose of Cinnulin PF®.*

Cinnamon Key Mechanisms

Supports healthy metabolic function*

Supports healthy insulin sensitivity [1–8]

Supports the insulin signaling pathway  [1,3,9]

Supports glucose transporter GLUT4 [10–12]

Supports healthy fat levels and blood/liver lipid levels [1,4,7–9,11,13,14]

Supports lean mass [15]

Supports adiponectin levels [1]

Supports antioxidant defenses*

Counters reactive oxygen species (ROS) production and oxidative stress [13,18,19]

Supports antioxidant defenses [19]

Replenishes glutathione (GSH) levels [19]

Supports signaling pathways*

Supports AMP-activated protein kinase (AMPK) signaling [4,10,16]

Supports liver kinase B1 (LKB1)  [10]

Supports peroxisome proliferator-activated receptor alpha (PPARα) and delta (PPARδ); modulates PPAR gamma (PPARγ) [4,11,17]

Supports cellular signaling*

Supports healthy immune signaling [3,20,21]

Supports mitochondrial structure and function [22,23]

Supports a healthy gut microbiota*

Supports a healthy gut microbiota composition [24,25]

Supports gut barrier function [24]

Promotes healthy aging and longevity*

Supports neuroprotective functions [26]

Supports healthy liver function [11]

Supports heat-shock protein 70 (HSP70) [27]

Supports SIRT1, SIRT2, and SIRT3 [20,21]

Supports uncoupling protein 1 (UCP1) [12,14]

Supports lifespan extension(Drosophila melanogaster) [27]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.


[1] B. Qin, M. M. Polansky, R. A. Anderson, Horm. Metab. Res. 42, 187–193 (2010).
[2] J. G. Wang et al., Fertil. Steril. 88, 240–243 (2007).
[3] B. Qin, H. D. Dawson, N. W. Schoene, M. M. Polansky, R. A. Anderson, Nutrition. 28, 1172–1179 (2012).
[4] B. Huang, H. D. Yuan, D. Y. Kim, H. Y. Quan, S. H. Chung, J. Agric. Food Chem. 59, 3666–3673 (2011).
[5] M. Hajimonfarednejad et al., Phytother. Res. 32, 276–283 (2018).
[6] R. Zare, A. Nadjarzadeh, M. M. Zarshenas, M. Shams, M. Heydari, Clin. Nutr. (2018), doi:10.1016/j.clnu.2018.03.003.
[7] A. Borzoei, M. Rafraf, M. Asghari-Jafarabadi, Asia Pac. J. Clin. Nutr. 27, 556–563 (2018).
[8] R. A. Anderson et al., Afr. J. Tradit. Complement. Altern. Med. 6, 332–336 (2016).
[9] B. Qin, M. M. Polansky, Y. Sato, K. Adeli, R. A. Anderson, J. Nutr. Biochem. 20, 901–908 (2009).
[10] Y. Shen et al., PLoS One. 9, e87894 (2014).
[11] X. Sheng, Y. Zhang, Z. Gong, C. Huang, Y. Q. Zang, PPAR Res. 2008, 581348 (2008).
[12] Y. Shen et al., Biosci. Biotechnol. Biochem. 74, 2418–2425 (2010).
[13] A. Borzoei et al., Afr. J. Tradit. Complement. Altern. Med. 8, 128–133 (2018).
[14] Y. Tamura, Y. Iwasaki, M. Narukawa, T. Watanabe, J. Nutr. Sci. Vitaminol. . 58, 9–13 (2012).
[15] T. N. Ziegenfuss, J. E. Hofheins, R. W. Mendel, J. Landis, R. A. Anderson, J. Int. Soc. Sports Nutr. 3, 45–53 (2006).
[16] C. Kopp et al., Int. J. Mol. Sci. 15, 2906–2915 (2014).
[17] J.-E. Li et al., Am. J. Chin. Med. 43, 879–892 (2015).
[18] A.-M. Roussel, I. Hininger, R. Benaraba, T. N. Ziegenfuss, R. A. Anderson, J. Am. Coll. Nutr. 28, 16–21 (2009).
[19] A. S. Sahib, J Intercult Ethnopharmacol. 5, 108–113 (2016).
[20] B. Qin, K. S. Panickar, R. A. Anderson, Nutrition. 30, 210–217 (2014).
[21] B. Qin, K. S. Panickar, R. A. Anderson, Life Sci. 102, 72–79 (2014).
[22] K. Couturier et al., J. Nutr. Biochem. 28, 183–190 (2016).
[23] K. S. Panickar, M. M. Polansky, R. A. Anderson, Exp. Neurol. 216, 420–427 (2009).
[24] M. Van Hul et al., Am. J. Physiol. Endocrinol. Metab. 314, E334–E352 (2018).
[25] Q.-Y. Lu et al., J. Food Sci. 82, 1807–1813 (2017).
[26] D. W. Peterson et al., J. Alzheimers. Dis. 17, 585–597 (2009).
[27] S. E. Schriner et al., Exp. Gerontol. 60, 220–230 (2014).