Sweet Orange | Blood orange
Citrus × sinensis, which includes sweet oranges and blood oranges, is regularly consumed in the diet. The peels and fruit are a rich source of the polymethoxylated flavones nobiletin and tangeretin. They also contain the flavanone hesperidin and lesser amounts of other citrus bioflavonoids. Citrus bioflavonoids were once called vitamin P and have been used to support healthy blood vessels and veins. Flavonoids tend to promote antioxidant defenses and a balanced cellular response. Citrus flavonoids share these properties. This citrus bioflavonoid extract has been concentrated for the unique polymethoxylated flavone nobiletin, a clock-enhancing small molecule used to support body clock function and metabolic health.
A Citrus × sinensis extract standardized for 40% nobiletin was selected because this unique polymethoxylated flavone is a modulator of clock function (i.e., circadian system).
The immature dried fruit of Citrus × sinensis is used as a source for nobiletin. In addition to a standardized amount of this polymethoxylated bioflavonoid, the dried fruit contains a range of other citrus bioflavonoids.
This standardized extract is supplied by Brewster Nutrition, a leader in citrus bioflavonoids since 1950. The 40% standardized extract is their highest concentration for nobiletin. It’s an expensive ingredient, but worth it.
Many flavonoid molecules are part of plants’ protective responses to mild environmental stress. Consuming them tends to produce adaptive functional responses, upregulating pathways that provide stress resistance. We think of polymethoxylated flavones like nobiletin and citrus bioflavonoids in general as having threshold effects. When combined with other flavonoids we think it’s better to use them following hormetic dosing principles (see Neurohacker Dosing Principles). Flavonoids are additive, and often synergistic with other polyphenol compounds, so the combination of all polyphenols in a formulation should be considered when determining dosage (not the amount of a single polyphenol molecule in isolation). When we dose Citrus × sinensis we consider the content of other polyphenols in the formulation and adjust the dose accordingly.
Mitochondrial structure and function
Protection of organs and systems
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.