Lithium Orotate

Overview:
Lithium orotate is a salt of orotic acid and lithium with neuroprotective effects. Lithium orotate can improve mood and may help preserve cognitive function.

Scientific Name:
Lithium 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylate

Mechanisms:

  • Lithium orotate provides lithium to the body[1]
  • Neuroprotective effects through inhibition of neuronal damaging proteins[3]
  • Increases the elimination of harmful toxic metals from the brain[4]
  • May increase gray matter[5]
  • Analgesic effect – decreases migraines[6]
References

[1] Smith DF & Schou M (1979). Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate. J Pharm Pharmacol, ;31(3):161-3. doi: 10.1111/j.2042-7158.1979.tb13461.x
[2] Oruch R, et al (2014). Lithium: a review of pharmacology, clinical uses, and toxicity. Eur J Pharmacol, 740:464-73. doi: 10.1016/j.ejphar.2014.06.042
[3] Vo TM, et al (2015). Is lithium a neuroprotective agent? Ann Clin Psychiatry, 27(1):49-54
[4] Moore GJ, et al (2000). Lithium-induced increase in human brain grey matter. Lancet, 356(9237):1241-2. doi: 10.1016/S0140-6736(00)02793-8
[5] Schettini G, et al (1992). Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol Biochem Behav, 43(1):139-51. doi: 10.1007/s10571-008-9343-5
[6] Oedegaard KJ, et al (2000). Are migraine and bipolar disorders comorbid phenomena?: findings from a pharmacoepidemiological study using the Norwegian Prescription Database. J Clin Psychopharmacol, 31(6):734-9. doi: 10.1097/JCP.0b013e318235f4e9