Mucuna pruriens Seed

Overview:
Mucuna pruriens is a bean with neuroprotective and adaptogenic effects. Mucuna pruriens is a mood enhancer and increases focus and motivation.

Scientific Name:
Mucuna pruriens, L-3,4-dihydroxyphenylalanine

Mechanisms:

  • L-DOPA is its main active substance[1]
  • Regulates the levels of dopamine, noradrenaline, adrenaline and serotonin in the brain[2]
  • Synergistic with P5P in the production of dopamine[3]
  • Anxiolytic effects[4]
  • Reduces the production of cortisol in response to stress[5]
  • Decreases the levels of free radicals, reactive oxygen species, neurotoxins and heavy metal poisoning[6]
  • Increases the production of growth hormone and melanin[7]
References

[1] Pulikkalpura H, et al (2015). Levodopa in Mucuna pruriens and its degradation. Sci Rep, 5:11078. doi: 10.1038/srep11078
[2] Misu Y, et al (1996). Neurobiology of L-DOPAergic systems. Prog Neurobiol, 49(5):415-54. doi: 10.1016/0301-0082(96)00025-1
[3] Das Gupta V, Gupta A (1980). Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa. J Pharm Sci, 69(10):1145-8. doi: 10.1002/jps.2600691005
[4] Rana DG, Galani VJ (2014). Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu, 35(1):90-7. doi: 10.4103/0974-8520.141949
[5] Shukla KK, et al (2007). Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men. Evid Based Complement Alternat Med, 7(1):137-44. doi: 10.1093/ecam/nem171
[6] Lampariello LR, et al (2012). The Magic Velvet Bean of Mucuna pruriens. J Tradit Complement Med, 2(4):331-9. PMID: 24716148
[7] Chihara K, et al (1986). L-dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans. J Clin Endocrinol Metab, 62(3):466-73. doi: 10.1210/jcem-62-3-466