NooGandha® Liposomal Ashwagandha (Withania somnifera) Root and Leaf Extract

Common Name

Ashwagandha | Indian ginseng 


Top Benefits of NooGandha® Liposomal Ashwagandha

Supports healthy stress resistance*

Supports cognitive performance*


What is NooGandha® Liposomal Ashwagandha?

Noogandha® is a clinically studied liposomal ashwagandha extract. The "Noo" (for nootropic) gives away the reason it was developed and its emphasis—cognitive performance. Ashwagandha (i.e., Indian ginseng) is a Rasayana—the category of elixirs and tonic herbs prized by the branch of Ayurvedic medicine concerned with rejuvenation, and focused on promoting a youthful state of physical and mental health. Ashwagandha holds a prominent place among the Rasayana herbs, where it was used for many reasons including as general tonic and to infuse energy and vigor in circumstances characterized by exhaustion or a lack of physical energy. A key attribute is that ashwagandha promotes balance. As the English name Indian ginseng implies, ashwagandha was believed to share some of the attributes of ginseng, in essence supporting multiple areas of health and well-being, especially under conditions characterized by increased stress. Herbs that promote these types of nonspecific resistance to and recovery from stress—and which typically also support general well-being, healthy energy, and homeostasis—are called adaptogens.  In two randomized, double-blind, placebo-controlled human trials, NooGandha® supported cognitive function and a healthy stress response.* 


Neurohacker’s NooGandha® Liposomal Ashwagandha Sourcing

NooGandha® is an ashwagandha root and leaf extract whose composition and research demonstrate support for cognitive function. NooGandha®’s extraction process focuses on specific compounds with nootropic bioactivity, with less of the compounds that show a calming effect while still retaining the stress support benefits of ashwagandha.* 

NooGandha® is made from ashwagandha grown in India and standardized to contain not less than 4% withanolides. 

NooGandha® is a registered trademark of Specnova LLC, USA.

NooGandha® is a non-GMO, gluten-free, and vegan ingredient.


NooGandha® Liposomal Ashwagandha Dosing Principles and Rationale

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. The studied dose range for NooGandha® is 225-400 mg [1,2]. In a 30-day study that compared 225 mg and 400 mg doses, the better overall combination of cognitive and stress support occurred with the lower dose [1]. We opted to recommend a  225 mg dose to be consistent with the results of this study, as well as with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.*


Withania somnifera Key Mechanisms

Supports brain function*

Supports cognitive performance [1,3–5]

Supports GABAergic neurotransmission [6–9] 

Supports dopamine levels [10]

Influences acetylcholinesterase activity [10]

Supports neuroprotective functions [10–13]

Influences neural immune signaling [13,14]


Supports a healthy mood and stress response*

Supports a calm mood [1,14,15]

Supports healthy stress responses [16–18]

Supports healthy stress hormone levels [1,16–18]


Promotes healthy sleep*

Supports sleep onset [9,15]

Supports sleep efficiency [15]

Supports quality of sleep [15,19]

Supports slow wave sleep [9]

Supports total sleep time [9]


Supports mitochondrial structure and function*

Supports mitochondrial function [12,20]

Supports electron transport chain activity [10–12,21]

Supports citric acid cycle enzymes [21]


Promotes exercise performance*

Supports endurance performance [22,23]

Supports muscle strength [19,24]

Supports post-exercise recovery [24]


Supports healthy metabolism*

Supports healthy insulin sensitivity [14,25–28]

Supports healthy blood glucose levels [25–29]

Supports healthy leptin signaling [14,28]


Promotes a healthy body weight*

Supports healthy body weight [14,28]

Supports healthy feeding behaviors [14,16]

Supports lean mass [24]


Enhances antioxidant defenses*

Supports antioxidant defenses [10–12,29,30]

Counters ROS levels and oxidative stress [10,12,13,20]


Supports healthy thyroid function*

Supports thyroid function [31–33]


Promotes healthy aging and longevity*

Supports lifespan (Caenorhabditis elegans) [13,34]

Supports insulin-like growth factor-1 (IGF-1) signaling [13,34]

Upregulates FOXO3A and SIRT3 [35]

Supports healthy immune signaling [14,25,26]


*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.


References 

[1]A. Remenapp, K. Coyle, T. Orange, T. Lynch, D. Hooper, S. Hooper, K. Conway, H.A. Hausenblas, J. Ayurveda Integr. Med. 13 (2021) 100510.

[2]D. Xing, C. Yoo, C.J. Rasmussen, J. Int. Soc. Sports Nutr. 17 (2020) 59.

[3]U. Pingali, R. Pilli, N. Fatima, Pharmacognosy Res. 6 (2014) 12–18.

[4]K.N.R. Chengappa, C.R. Bowie, P.J. Schlicht, D. Fleet, J.S. Brar, R. Jindal, J. Clin. Psychiatry 74 (2013) 1076–1083.

[5]D. Choudhary, S. Bhattacharyya, S. Bose, J. Diet. Suppl. 14 (2017) 599–612.

[6]A.K. Mehta, P. Binkley, S.S. Gandhi, M.K. Ticku, Indian J. Med. Res. 94 (1991) 312–315.

[7]J.P. Bhattarai, S.A. Park, S.K. Han, Phytotherapy Research (2009).

[8]H. Yin, D.H. Cho, S.J. Park, S.K. Han, The American Journal of Chinese Medicine 41 (2013) 1043–1051.

[9]A. Kumar, H. Kalonia, Indian J. Pharm. Sci. 70 (2008) 806–810.

[10]M.J. Manjunath, Muralidhara, J. Food Sci. Technol. 52 (2015) 1971–1981.

[11]P. Kumar, A. Kumar, J. Med. Food 12 (2009) 591–600.

[12]A. Sood, A. Mehrotra, D.K. Dhawan, R. Sandhir, Metab. Brain Dis. 33 (2018) 1261–1274.

[13]B.A. Akhoon, S. Pandey, S. Tiwari, R. Pandey, Exp. Gerontol. 78 (2016) 47–56.

[14]T. Kaur, G. Kaur, J. Neuroinflammation 14 (2017) 201.

[15]D. Langade, S. Kanchi, J. Salve, K. Debnath, D. Ambegaokar, Cureus 11 (2019) e5797.

[16]D. Choudhary, S. Bhattacharyya, K. Joshi, J. Evid. Based Complementary Altern. Med. 22 (2017) 96–106.

[17]K. Chandrasekhar, J. Kapoor, S. Anishetty, Indian J. Psychol. Med. 34 (2012) 255–262.

[18]B. Auddy, J. Hazra, A. Mitra, B. Abedon, S. Ghosal, Journal of American Nutraceutical Association 11 (2008) 50–56.

[19]A.A. Raut, N.N. Rege, F.M. Tadvi, P.V. Solanki, K.R. Kene, S.G. Shirolkar, S.N. Pandey, R.A. Vaidya, A.B. Vaidya, J. Ayurveda Integr. Med. 3 (2012) 111–114.

[20]P. Parihar, R. Shetty, P. Ghafourifar, M.S. Parihar, Cell. Mol. Biol. 62 (2016) 73–83.

[21]P. Senthilnathan, R. Padmavathi, V. Magesh, D. Sakthisekaran, Life Sci. 78 (2006) 1010–1014.

[22]J.S. Sandhu, B. Shah, S. Shenoy, S. Chauhan, G.S. Lavekar, M.M. Padhi, Int. J. Ayurveda Res. 1 (2010) 144–149.

[23]B. Choudhary, A. Shetty, D.G. Langade, Ayu 36 (2015) 63–68.

[24]S. Wankhede, D. Langade, K. Joshi, S.R. Sinha, S. Bhattacharyya, J. Int. Soc. Sports Nutr. 12 (2015) 43.

[25]M.R. Shahraki, Z. Samadi Noshahr, H. Ahmadvand, A. Nakhaie, J. Basic Clin. Physiol. Pharmacol. 27 (2016) 387–391.

[26]Z. Samadi Noshahr, M.R. Shahraki, H. Ahmadvand, D. Nourabadi, A. Nakhaei, Rep Biochem Mol Biol 3 (2015) 62–67.

[27]T. Anwer, M. Sharma, K.K. Pillai, M. Iqbal, Basic Clin. Pharmacol. Toxicol. 102 (2008) 498–503.

[28]J. Lee, J. Liu, X. Feng, M.A. Salazar Hernández, P. Mucka, D. Ibi, J.W. Choi, U. Ozcan, Nat. Med. 22 (2016) 1023–1032.

[29]T. Anwer, M. Sharma, K.K. Pillai, G. Khan, Acta Pol. Pharm. 69 (2012) 1095–1101.

[30]S.K. Gupta, A. Dua, B.P.S. Vohra, Drug Metabol. Drug Interact. 19 (2003) 211–222.

[31]A.K. Sharma, I. Basu, S. Singh, J. Altern. Complement. Med. 24 (2018) 243–248.

[32]J.M. Gannon, P.E. Forrest, K.N. Roy Chengappa, J. Ayurveda Integr. Med. 5 (2014) 241–245.

[33]R. Jatwa, A. Kar, Phytother. Res. 23 (2009) 1140–1145.

[34]B.A. Akhoon, L. Rathor, R. Pandey, Exp. Gerontol. 104 (2018) 113–117.

[35]R. Pradhan, R. Kumar, S. Shekhar, N. Rai, A. Ambashtha, J. Banerjee, M. Pathak, S.N. Dwivedi, S. Dey, A.B. Dey, Exp. Gerontol. 95 (2017) 9–15.