Pomegranate Fruit Extract

COMMON NAME

Pomegranate

TOP BENEFITS OF POMEGRANATE 

Supports antioxidant defenses *

Supports skin health and healthy skin aging *

Supports cognitive health *

Supports exercise recovery *

WHAT IS POMEGRANATE?

Pomegranate (Punica granatum) is a fruit-bearing tree native to the region extending from Iran to Northern India and Afghanistan. It has been cultivated since ancient times throughout the Mediterranean region, Middle East and South Asia. Pomegranate is known for its fruit, a round berry with a thick peel filled with arils with seeds. The name pomegranate derives from medieval Latin pōmum “apple” and grānātum “seeded”—a single pomegranate can have 200-1400 arils and seeds. The fruit ripens and can be found in markets in the Northern Hemisphere from October to February. The arils have a deep red color resulting from their high polyphenol content. The peel is also rich in polyphenols and other bioactive phytochemicals. This high polyphenolic content, which includes flavonoids, proanthocyanidins, and ellagitannins, gives pomegranate potent antioxidant activity. Pomegranate is particularly rich in ellagitannins, which are a specific type of polyphenol that releases ellagic acid upon chemical breakdown in the gut. Ellagitannins and ellagic acid have poor bioavailability, but they can be metabolized by the gut microbiota to form urolithins such as urolithin A, which are more bioavailable. Ellagitannins, through ellagic acid and its metabolites, are potent antioxidants and modulators of cellular signaling pathways involved in healthy aging and immune system function. Punicalagin, the largest known polyphenol, is the main ellagitannin in pomegranate [1–4].

NEUROHACKER’S POMEGRANATE SOURCING

Pomegranate Fruit Extract is made from the whole fruit and standardized for 40% ellagic acid. 

Pomegranate Fruit Extract is gluten-free, non-GMO, and vegan.

POMEGRANATE DOSING PRINCIPLES AND RATIONALE

In clinical studies, the dose of pomegranate extract used has ranged between about 100-1000 mg, with the dose used depending upon the concentration of pomegranate polyphenols in the extract and whether an extract has been used alone or with other ingredients. Ellagic acid has been used in clinical trials at doses as low as 50 mg per day [5]. A pomegranate extract providing about 10 mg of ellagitannins has been used when combined with a resveratrol-containing grape extract [6]. Since this extract is standardized for the amount of ellagic acid, dosing is designed to deliver an amount of that compound in the range consistent with research, with the lower end of the dosing range used when the pomegranate extract is combined with a grape extract. While pomegranate is a food, because the extract we use is standardized for the ellagic acid, and polyphenols tend to follow hormetic dosing principles (see Neurohacker Dosing Principles), we believe doses toward the middle to lower end of the dosing range, especially when combined with other flavonoid-containing ingredients, are sufficient to support healthy function. 

POMEGRANATE KEY MECHANISMS

Mitochondrial function

Supports mitochondrial function [7–19]

Supports ATP production [12,13]

Supports mitochondrial gene expression [8,12]

Supports peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) signaling [12,20]

Supports mitochondrial biogenesis [19]

Supports electron transport chain [12,16,20]

Supports mitochondrial membrane potential [13,14]

Supports mitophagy [10,21]

Supports mitochondrial antioxidant defenses and counters ROS production [14,16,18]

Brain and cognitive function

Supports memory [22–24]

Supports brain activation [23]

Supports cognitive health [5,25–27]

Influences acetylcholinesterase activity [28–30]

Supports synaptic function [31]

Supports neuroprotection [7,26,27,29–35]

Supports brain antioxidant defenses and counters oxidative stress [20,28,30,33]

Influences neural immune signaling [31,33,36]

Supports BDNF levels [29]

Supports neural ATP production [33]

Skin health

Supports skin protection against environmental aggressors (UV, pollution, ionizing radiation) [17,37–44]

Supports skin smoothness (may help with fine lines and skin wrinkle formation) [41,43]

Supports skin hydration [41]

Supports healthy melanin production and healthy pigmentation [45,46]

Supports skin immunity [40]

Supports the skin microbiota [13]

Supports healthy skin cell proliferation levels [47]

Supports healthy extracellular matrix physiology (MMP activity) [41–45,47–49]

Supports collagen production [41,43,48]

Supports hyaluronan synthesis/content [41,45]

Supports DNA repair and protection from DNA damage [17,40,47]

Supports skin antioxidant defenses and counters ROS production and oxidative stress [17,40–44,49]

Supports Nrf2 signaling and phase II detox enzyme production [17,44]

Influences immune signaling [40–42,45,50]

Influences skin degenerative signaling pathways (NF-κB) [40,51]

Gut microbiota

Supports a healthy gut microbiota [52–54]

Exercise performance 

Supports exercise performance [55,56]

Supports muscle function [21]

Supports exercise recovery [57–59]

Healthy aging and longevity

Supports healthy blood pressure [60,61]

Supports healthy blood lipid levels [5,61,62]

Supports plasma antioxidant capacity and counters oxidative stress [23,61–65]

Influences immune signaling [61,62,66]

Supports autophagy [10,31]

Supports mTOR signaling [31]

Supports AMP-Activated Protein Kinase (AMPK) signaling [9,11]

Supports Nrf2 signaling and phase II detox enzyme production [9,13,15,17]

Supports lifespan extension (Caenorhabditis elegans) [21]

Complementary ingredients

Grape extract and resveratrol in supporting skin health and antioxidant capacity [6] 


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