Rosemary (Rosmarinus officinalis) Leaf Extract


Rosemary | Garden Rosemary


Supports healthy aging*

Supports skin health*

Supports antioxidant defenses*


Rosemary is a member of the mint family. Its common name derives from Latin and translates as “dew of the sea.” Rosemary was used as a spice and herb by Egyptians, Greeks, and Latins cultures, thriving close to the coast, especially in dryer areas throughout the Mediterranean. Rosmarinus officinalis contains a range of health-supporting polyphenols, including diterpenes (e.g., carnosol, carnosic acid, rosmarinic acid), triterpenes (e.g., ursolic acid), and flavonoids (e.g., luteolin).* The diterpenes carnosol and carnosic acid are potent antioxidants that account for over 90% of the antioxidant activity in rosemary leaves [1].* 


Rosemary Leaf Extract is standardized to contain 7.5% Carnosic Acid + Carnosol.

Rosemary Leaf Extract is gluten-free, non-GMO, vegan, Kosher, and Halal certified.


We believe that rosemary extracts standardized for diterpenes should be thought of as following a threshold response (see Neurohacker Dosing Principles). This means that beyond a certain amount, there may be no additional functional benefits gained. As an example, a skin health study supplemented either 50 mg or 125 mg of a rosemary extract combined with similar amounts of a citrus extract. The lower amount performed as well as the higher amount [2]. In several skin studies where rosemary has been combined with lycopene-rich tomato fruit extracts, the serving used was also an amount closer to this 50 mg range of a standardized extract. Our serving for this rosemary extract was selected to be consistent with an amount that has been used when rosemary extracts have been combined with other skin health ingredients.*


Supports skin health*

Supports healthy extracellular matrix structure* [3]

Supports free radical scavenging and skin antioxidant defenses* [3–6]

Supports Nrf2 signaling* [7,8]

Counters ROS-induced premature senescence* [7]

Supports skin DNA integrity and repair* [3,4,9]

Supports immune signaling* [10–13]

Supports skin in adapting to environmental stress* [9]

Influences AhR signaling* [14]

Supports antioxidant defenses*

Supports antioxidant defenses* [15–21]

Counters reactive oxygen species (ROS) production* [16]

Supports Nrf2 signaling and phase II detoxification enzymes [7,22–25]

Supports healthy brain function*

Supports neuroprotective functions* [19,23]

Supports brain antioxidant defenses* [23]

Counters ROS production and oxidative stress in the brain* [16,19,23]

Supports general health, healthy aging, and longevity*

Supports healthy gut microbiota and microbial metabolism* [26]

Supports maintenance of healthy cholesterol levels* [18]

Supports healthy body weight* [21]

Supports maintenance of healthy blood/liver lipid levels* [21,27]

Supports AMPK signaling* [27–29]

Supports SIRT1 and SIRT6 signaling* [30] 

Counters advanced glycation end-products (AGEs) production* [21,31]

Supports healthy immune signaling* [18,21] 

Complementary ingredients*

Lycopene to support skin health* [32,33]

Citrus extracts to support skin health* [2,34]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


[1]G. Nieto, G. Ros, J. Castillo, Medicines (Basel) 5 (2018).

[2]V. Nobile, A. Michelotti, E. Cestone, N. Caturla, J. Castillo, O. Benavente-García, A. Pérez-Sánchez, V. Micol, Food Nutr. Res. 60 (2016) 31871.

[3]M. Park, J. Han, C.S. Lee, B.H. Soo, K.-M. Lim, H. Ha, Exp. Dermatol. 22 (2013) 336–341.

[4]L. Tong, S. Wu, Sci. Rep. 8 (2018) 3574.

[5]S.M. Ezzat, M.M. Salama, A.N. ElMeshad, M.H. Teaima, L.A. Rashad, Arch. Pharm. Res. 39 (2016) 912–925.

[6]G. Sancheti, P.K. Goyal, Phytother. Res. 20 (2006) 981–986.

[7]A.C. Carvalho, A.C. Gomes, C. Pereira-Wilson, C.F. Lima, Free Radic. Biol. Med. 83 (2015) 262–272.

[8]H. Kim, C.N. Ramirez, Z.-Y. Su, A.-N.T. Kong, J. Nutr. Biochem. 33 (2016) 54–62.

[9]N. Sánchez-Marzo, A. Pérez-Sánchez, E. Barrajón-Catalán, J. Castillo, M. Herranz-López, V. Micol, Antioxidants (Basel) 9 (2020).

[10]D.Y. Lee, C.J. Hwang, J.Y. Choi, M.H. Park, M.J. Song, K.W. Oh, D.J. Son, S.H. Lee, S.B. Han, J.T. Hong, Biomol. Ther. 25 (2017) 535–544.

[11]I.J. Yeo, J.H. Park, J.S. Jang, D.Y. Lee, J.E. Park, Y.E. Choi, J.H. Joo, J.K. Song, H.O. Jeon, J.T. Hong, Arch. Pharm. Res. 42 (2019) 274–283.

[12]E.S. Mengoni, G. Vichera, L.A. Rigano, M.L. Rodriguez-Puebla, S.R. Galliano, E.E. Cafferata, O.H. Pivetta, S. Moreno, A.A. Vojnov, Fitoterapia 82 (2011) 414–421.

[13]J. Oh, T. Yu, S.J. Choi, Y. Yang, H.S. Baek, S.A. An, L.K. Kwon, J. Kim, H.S. Rho, S.S. Shin, W.S. Choi, S. Hong, J.Y. Cho, Mediators Inflamm. 2012 (2012) 781375.

[14]A. Mohebati, J.B. Guttenplan, A. Kochhar, Z.-L. Zhao, W. Kosinska, K. Subbaramaiah, A.J. Dannenberg, Cancer Prev. Res. 5 (2012) 593–602.

[15]H. Rasoolijazi, M. Mehdizadeh, M. Soleimani, F. Nikbakhte, M. Eslami Farsani, S. Ababzadeh, Med. J. Islam. Repub. Iran 29 (2015) 187.

[16]G. de Almeida Gonçalves, A.B. de Sá-Nakanishi, J.F. Comar, L. Bracht, M.I. Dias, L. Barros, R.M. Peralta, I.C.F.R. Ferreira, A. Bracht, Food Funct. 9 (2018) 2328–2340.

[17]H.-L. Wang, Z.-O. Sun, R.-U. Rehman, H. Wang, Y.-F. Wang, H. Wang, J. Food Sci. 82 (2017) 1006–1011.

[18]S. Samarghandian, A. Borji, T. Farkhondeh, Cardiovasc. Hematol. Disord. Drug Targets 17 (2017) 11–17.

[19]H. Song, L. Xu, R. Zhang, Z. Cao, H. Zhang, L. Yang, Z. Guo, Y. Qu, J. Yu, Neurosci. Lett. 622 (2016) 95–101.

[20]F. Nazem, N. Farhangi, M. Neshat-Gharamaleki, Can J Diabetes 39 (2015) 229–234.

[21]Y. Zhao, R. Sedighi, P. Wang, H. Chen, Y. Zhu, S. Sang, J. Agric. Food Chem. 63 (2015) 4843–4852.

[22]T. Satoh, S.R. McKercher, S.A. Lipton, Free Radic. Biol. Med. 65 (2013) 645–657.

[23]M.R. de Oliveira, Mol. Neurobiol. 53 (2016) 6155–6168.

[24]K.W. Singletary, Cancer Lett. 100 (1996) 139–144.

[25]K.W. Singletary, J.T. Rokusek, Plant Foods Hum. Nutr. 50 (1997) 47–53.

[26]M. Romo-Vaquero, M.-V. Selma, M. Larrosa, M. Obiol, R. García-Villalba, R. González-Barrio, N. Issaly, J. Flanagan, M. Roller, F.A. Tomás-Barberán, M.-T. García-Conesa, PLoS One 9 (2014) e94687.

[27]F. Vlavcheski, M. Naimi, B. Murphy, T. Hudlicky, E. Tsiani, Molecules 22 (2017).

[28]M. Naimi, T. Tsakiridis, T.C. Stamatatos, D.I. Alexandropoulos, E. Tsiani, Appl. Physiol. Nutr. Metab. 40 (2015) 407–413.

[29]M. Naimi, F. Vlavcheski, B. Murphy, T. Hudlicky, E. Tsiani, Clin. Exp. Pharmacol. Physiol. 44 (2017) 94–102.

[30]L. Gao, W. Shan, W. Zeng, Y. Hu, G. Wang, X. Tian, N. Zhang, X. Shi, Y. Zhao, C. Ding, F. Zhang, K. Liu, J. Yao, Mol. Nutr. Food Res. 60 (2016) 1902–1911.

[31]J. Ou, J. Huang, M. Wang, S. Ou, Food Chem. 221 (2017) 1057–1061.

[32]K. Groten, A. Marini, S. Grether-Beck, T. Jaenicke, S.H. Ibbotson, H. Moseley, J. Ferguson, J. Krutmann, Skin Pharmacol. Physiol. 32 (2019) 101–108.

[33]E. Tarshish, K. Hermoni, S.R. Schwartz, Clinical Pharmacology & Biopharmaceutics 9 (2020).

[34]A. Pérez-Sánchez, E. Barrajón-Catalán, N. Caturla, J. Castillo, O. Benavente-García, M. Alcaraz, V. Micol, J. Photochem. Photobiol. B 136 (2014) 12–18.