SoyLife® Soy Germ Extract


Soy Germ | Soy Isoflavones


Supports skin health *

Supports women’s health maintenance* 

Supports maintenance of healthy cognitive function *


Soy is a legume (i.e., bean) native to East Asia, where it is used to make a variety of fermented foods, such as soy sauce, tofu, tempeh, and miso. Most legumes, and some nuts and seeds, contain a type of bioflavonoid called isoflavones. Soybeans are the most common source of isoflavones in human food; the major isoflavones in soybean are daidzein, glycitein, and genistein. SoyLife® is a soy germ extract. The soy germ is the part of the bean that germinates (or sprouts). Because the germ is what grows into a new plant, it is rich in phytonutrients—more than 25% of all soy nutrients are stored in the germ, and the soy germ contains higher concentrations of isoflavones relative to the whole soybean. The soy germ extract is also richer in the isoflavone daidzein. This is important because, in humans, daidzein is partially metabolized by the gut microbiota to produce the isoflavone equol, which is more bioavailable to humans and believed to be the most important metabolite for many of the soy isoflavone health benefits [1–3].*


SoyLife® is a soy germ extract standardized to contain 40% isoflavones. It has a ratio of genistein:daidzein:glycitein of approximately 15:50:35. 

SoyLife® has been a leading soy isoflavone product for 25 years and has been used in more than 35 scientific studies.

SoyLife® Soy Germ Extract  is non-GMO, gluten-free, vegan, Kosher, and Halal certified. Soy isoflavones have GRAS status in the United States.

SoyLife® is a registered trademark of Frutarom.


Soy is rich in isoflavones; fermenting soybeans increases the content of isoflavones in soy foods. Because of this, cuisines that consistently consume fermented soybean foods have much higher isoflavone intake than Western diets. Average daily intake of soy isoflavones in the Japanese diet is 25-50 mg, for example. In the USA and Europe, average intake is less than 3 mg and often less than 1 mg a day [4]. Human studies of soy isoflavones have most commonly used a dose of 40-160 mg, with the low end of the range closely mimicking the average intake from a Japanese diet. SoyLife® Soy Germ Extract provides 40 mg isoflavones per 100 mg of the extract and has been used in a number of human studies: based on these studies, the recommended daily dosage is 100-300 mg of the soy germ extract (40-120 mg isoflavones) per day. We use a dose consistent with the lower end of the studied range for several reasons. One reason is that isoflavones are polyphenolic compounds, which tend to follow hormetic dosing principles (see Neurohacker Dosing Principles), which means that beyond a certain dose, there may be no additional functional benefits gained (and sometimes there can be lesser benefits at higher doses compared with lower doses). Another reason is that a 40 mg dose is in the range supplied by diets that are rich in fermented soy foods. And, the last reason has to do with its use in our formula: a 40 mg dose of soy isoflavones has been sufficient to support skin health and appearance [5].*


Supports skin health*

May help minimize the appearance of fine lines and wrinkles [5–7]

Supports skin elasticity [5]

Supports healthy skin structure [8] 

Supports fibroblast renewal [9] 

Supports dermal extracellular matrix (ECM) structure (collagen, elastic fibers, hyaluronic acid levels) [6,8–13] 

Influences ECM breakdown enzymes [6,9,12] 

Supports dermal vascularity [8] 

Supports skin in adapting to environmental stress [6,14–23] 

Supports healthy DNA structure and repair [9,12,14,15,18–20,23] 

Supports healthy immune/cytokine signaling [12,22–25]

Supports antioxidant defenses [9,12]

Counters oxidative stress [10,13,20,26]

Supports ERβ - Nrf2 signaling pathway [27,28]

Influences skin androgen signaling (via type 1 5α-reductase) [9,12,29] 

Counters advanced glycation end product (AGE) production [30]

Counters the expression of human skin aging biomarkers (S100 CBP A8 and S100 CBP A9) [9]

Supports brain health*

Supports maintenance of healthy frontal lobe function [31]

Supports spatial working memory [32,33]

Supports aspects of executive function [33]

Supports a healthy gut microbiota*

Supports a healthy gut microbiota [34–37]

Complementary ingredients*

With astaxanthin in supporting skin health [38]

With lycopene, vitamin C and vitamin E in supporting skin health [39]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.


[1]S. Davinelli, J.C. Bertoglio, A. Polimeni, G. Scapagnini, Curr. Pharm. Des. 24 (2018) 99–105.

[2]M. Messina, Nutrients 8 (2016).

[3]K.D.R. Setchell, C. Clerici, E.D. Lephart, S.J. Cole, C. Heenan, D. Castellani, B.E. Wolfe, L. Nechemias-Zimmer, N.M. Brown, T.D. Lund, R.J. Handa, J.E. Heubi, Am. J. Clin. Nutr. 81 (2005) 1072–1079.

[4]G. Rizzo, L. Baroni, Nutrients 10 (2018).

[5]T. Izumi, M. Saito, A. Obata, M. Arii, H. Yamaguchi, A. Matsuyama, J. Nutr. Sci. Vitaminol. 53 (2007) 57–62.

[6]S.-Y. Kim, S.-J. Kim, J.-Y. Lee, W.-G. Kim, W.-S. Park, Y.-C. Sim, S.-J. Lee, J. Am. Coll. Nutr. 23 (2004) 157–162.

[7]A. Oyama, T. Ueno, S. Uchiyama, T. Aihara, A. Miyake, S. Kondo, K. Matsunaga, Menopause 19 (2012) 202–210.

[8]A. Accorsi-Neto, M. Haidar, R. Simões, M. Simões, J. Soares Jr, E. Baracat, Clinics 64 (2009) 505–510.

[9]R. Gopaul, H.E. Knaggs, E.D. Lephart, Biofactors 38 (2012) 44–52.

[10]E. Duchnik, J. Kruk, I. Baranowska-Bosiacka, A. Pilutin, R. Maleszka, M. Marchlewicz, Postepy Dermatol Alergol 36 (2019) 760–766.

[11]K. Miyazaki, T. Hanamizu, R. Iizuka, K. Chiba, Skin Pharmacol. Appl. Skin Physiol. 16 (2003) 108–116.

[12]E.D. Lephart, Pharm. Biol. 51 (2013) 1393–1400.

[13]P. Sienkiewicz, A. Surazyński, J. Pałka, W. Miltyk, Acta Pol. Pharm. 65 (2008) 203–211.

[14]B. Iovine, M.L. Iannella, F. Gasparri, V. Giannini, G. Monfrecola, M.A. Bevilacqua, Int. J. Mol. Sci. 13 (2012) 16444–16456.

[15]B. Iovine, M. Garofalo, M. Orefice, V. Giannini, F. Gasparri, G. Monfrecola, M.A. Bevilacqua, Clin. Exp. Dermatol. 39 (2014) 391–394.

[16]T.-M. Chiu, C.-C. Huang, T.-J. Lin, J.-Y. Fang, N.-L. Wu, C.-F. Hung, J. Ethnopharmacol. 126 (2009) 108–113.

[17]S. Widyarini, D. Domanski, N. Painter, V.E. Reeve, Photochem. Photobiol. Sci. 11 (2012) 1186–1192.

[18]H. Wei, R. Saladi, Y. Lu, Y. Wang, S.R. Palep, J. Moore, R. Phelps, E. Shyong, M.G. Lebwohl, J. Nutr. 133 (2003) 3811S–3819S.

[19]J.O. Moore, Y. Wang, W.G. Stebbins, D. Gao, X. Zhou, R. Phelps, M. Lebwohl, H. Wei, Carcinogenesis 27 (2006) 1627–1635.

[20]V.A. Terra, F.P. Souza-Neto, M.A.C. Frade, L.N.Z. Ramalho, T.A.M. Andrade, A.A.C. Pasta, A.C. Conchon, F.A. Guedes, R.C. Luiz, R. Cecchini, A.L. Cecchini, J. Photochem. Photobiol. B 144 (2015) 20–27.

[21]Y.N. Wang, W. Wu, H.C. Chen, H. Fang, J. Dermatol. Sci. 58 (2010) 19–27.

[22]K. Isoherranen, K. Punnonen, C. Jansen, P. Uotila, Br. J. Dermatol. 140 (1999) 1017–1022.

[23]B. Iovine, M.L. Iannella, F. Gasparri, G. Monfrecola, M.A. Bevilacqua, J. Biomed. Biotechnol. 2011 (2011) 692846.

[24]T.H. Lee, M.H. Do, Y.L. Oh, D.W. Cho, S.H. Kim, S.Y. Kim, J. Agric. Food Chem. 62 (2014) 8962–8972.

[25]J.S. Kang, Y.D. Yoon, M.H. Han, S.-B. Han, K. Lee, M.R. Kang, E.-Y. Moon, Y.J. Jeon, S.-K. Park, H.M. Kim, Biochem. Pharmacol. 71 (2005) 136–143.

[26]M.A. Rahman Mazumder, P. Hongsprabhas, Biomed. Pharmacother. 82 (2016) 379–392.

[27]T. Zhang, X. Liang, L. Shi, L. Wang, J. Chen, C. Kang, J. Zhu, M. Mi, PLoS One 8 (2013) e79075.

[28]E.B. Froyen, F.M. Steinberg, J. Nutr. Biochem. 22 (2011) 843–848.

[29]P. Riyanto, P. Subchan, R. Lelyana, Dermatoendocrinol. 7 (2015) e1063751.

[30]L. Lv, X. Shao, H. Chen, C.-T. Ho, S. Sang, Chem. Res. Toxicol. 24 (2011) 579–586.

[31]S.E. File, D.E. Hartley, S. Elsabagh, R. Duffy, H. Wiseman, Menopause 12 (2005) 193–201.

[32]A.A. Thorp, N. Sinn, J.D. Buckley, A.M. Coates, P.R.C. Howe, Br. J. Nutr. 102 (2009) 1348–1354.

[33]C.E. Gleason, C.M. Carlsson, J.H. Barnet, S.A. Meade, K.D.R. Setchell, C.S. Atwood, S.C. Johnson, M.L. Ries, S. Asthana, Age Ageing 38 (2009) 86–93.

[34]C. Iino, T. Shimoyama, K. Iino, Y. Yokoyama, D. Chinda, H. Sakuraba, S. Fukuda, S. Nakaji, Nutrients 11 (2019).

[35]C.H. Nakatsu, A. Armstrong, A.P. Clavijo, B.R. Martin, S. Barnes, C.M. Weaver, PLoS One 9 (2014) e108924.

[36]P. López, M. Sánchez, C. Perez-Cruz, L.A. Velázquez-Villegas, T. Syeda, M. Aguilar-López, A.K. Rocha-Viggiano, M. Del Carmen Silva-Lucero, I. Torre-Villalvazo, L.G. Noriega, N. Torres, A.R. Tovar, Mol. Nutr. Food Res. 62 (2018) e1800313.

[37]G. Huang, J. Xu, D.E. Lefever, T.C. Glenn, T. Nagy, T.L. Guo, Toxicol. Appl. Pharmacol. 332 (2017) 138–148.

[38]J. Shin, J.-E. Kim, K.-J. Pak, J.I. Kang, T.-S. Kim, S.-Y. Lee, I.-H. Yeo, J.H.Y. Park, J.H. Kim, N.J. Kang, K.W. Lee, Int. J. Mol. Sci. 18 (2017).

[39]G. Jenkins, L.J. Wainwright, R. Holland, K.E. Barrett, J. Casey, Int. J. Cosmet. Sci. 36 (2014) 22–31.