Potassium as Tripotassium Citrate

Potassium Citrate Common Names

Tripotassium Citrate | Potassium | Citrate | Citric Acid

Top Benefits of Potassium Citrate

  • Supports electrolyte balance*
  • Supports cellular energy*
  • Supports neuronal function*
  • Supports muscle function*

What Is Potassium Citrate?

Tripotassium citrate is a chelated form of the mineral potassium, with three potassium ions bound to a single citrate molecule. Both molecules are involved in supporting efficient cellular energy production. Potassium is one of the most abundant minerals in the body and is vital for the functioning of all living cells. Its main role is as an intracellular electrolyte (sodium is the main extracellular electrolyte). Potassium is needed for electrolyte balance, which supports the electrical functions of cells. Citrate is a salt of citric acid, a compound that was first identified in lemon juice, but is found in all citrus fruits. Citrate is an intermediate in the citric acid cycle (also called the Krebs cycle), a circular pathway that helps turn food into energy (i.e., ATP) and build important biomolecules. Adding intermediates like citrate into this cycle helps upregulate the flux (i.e., the cycle can essentially spin faster). Citrate is also a vital component of bone. 

Neurohacker’s Potassium Citrate Sourcing

We opt to use the citrate sale of potassium, instead of a different form of potassium, when both potassium and citrate play a role supporting pathways or processes in a formulation.

Potassium citrate sourcing is focused on ensuring it is non-GMO, gluten-free and vegan.

Tripotassium Citrate Dosing Principles and Rationale

Tripotassium citrate is used primarily as a source of citrate, an important Krebs cycle and mitochondrial nutrient. We dose it in small amounts to augment dietary intake. The adequate intake (AI) for potassium in adults is 3400 mg for men and 2600mg for women. Supplements will typically contain 99 mg or less per serving because of certain FDA constraints with potassium dosing. This amount would not be sufficient to correct issues with potassium intake.

Potassium Citrate Key Mechanisms

  • Main positively charged ion in intracellular fluid[1,2]
  • Along with sodium, potassium creates an electrochemical gradient across cell membranes known as the membrane potential[1,2]
  • Essential for nerve impulse transmission, muscle contraction and heart function[2]
  • Potassium is required for the activity of a few enzymes including pyruvate kinase (catalyzes the final step of glycolysis)[3]
  • Supports insulin secretion[4]
  • Regulates blood flow and blood pressure[4,5,6]
  • Protects kidney function[7,8]


[1] J. M. Berg, J. L. Tymoczko, G. J. Gatto, L. Stryer, Eds., Biochemistry (W.H. Freeman and Company, 8th ed., 2015).
[2] W. Boron, E. Boulpaep, Eds., Medical Physiology (Elsevier, 3rd ed., 2016).
[3] M. J. Page, E. Di Cera, Physiol. Rev. 86, 1049–1092 (2006).
[4] C. Ekmekcioglu, I. Elmadfa, A. L. Meyer, T. Moeslinger, J. Physiol. Biochem. 72, 93–106 (2016).
[5] F. J. Haddy, P. M. Vanhoutte, M. Feletou, Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R546–52 (2006).
[6] M. S. Stone, L. Martyn, C. M. Weaver, Nutrients. 8 (2016), doi:10.3390/nu8070444.
[7] C. M. Weaver, Adv. Nutr. 4, 368S–77S (2013).
[8] C. P. Kovesdy et al., J. Am. Soc. Hypertens. 11, 783–800 (2017).