Vinpocetine is a vasoactive alkaloid derived from Periwinkle with neuroprotective and nootropic actions. Studies indicate that vinpocetine can benefit attention and memory, decrease fatigue and increase alertness.

Scientific Name:
Ethyl apovincaminate


  • Neuroprotective against a wide array of neurotoxic chemicals – through inhibition of voltage-gated sodium channels and reduction of calcium-influx into neuronal cells[1]
  • Anti-inflammatory activity – reduces TNFα-induced expression of pro-inflammatory molecules[2]
  • Cerebral vasodilation through phosphodiesterase (PDE) type-1 inhibition – increased blood flow in the brain[3]
  • Improved brain metabolism due to increased glucose availability – leading to increased neuronal ATP
  • Upregulates acetylcholine, noradrenaline, serotonin, and dopamine receptors[4,5]
  • Cerebral antioxidant[6]

[1] Bönöczk P, et al (2000). Role of sodium channel inhibition in neuroprotection: effect of vinpocetine. Brain Res Bull, 53(3):245-54. doi: 10.1016/S0361-9230(00)00354-3
[2] Wang H, et al (2014). Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury. Neurosci Lett, 566:247-51. doi: 10.1016/j.neulet.2014.02.045
[3] Hagiwara M, et al (1984). Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem Pharmacol, 33(3):453-7. doi: 10.1016/0006-2952(84)90240-5
[4] Gaál L & Molnár P (1990). Effect of vinpocetine on noradrenergic neurons in rat locus coeruleus. Eur J Pharmacol, 187(3):537-9. doi: 10.1016/0014-2999(90)90383-H
[5] Herrera-Mundo N & Sitges M (2013). Vinpocetine and α-tocopherol prevent the increase in DA and oxidative stress induced by 3-NPA in striatum isolated nerve endings. J Neurochem. 124(2):233-40. doi: 10.1111/jnc.12082
[6] Solanki P, et al (2011). Preventive effect of piracetam and vinpocetine on hypoxia-reoxygenation induced injury in primary hippocampal culture. Food Chem Toxicol, 49(4):917-22. doi: 10.1016/j.fct.2010.12.015

Terms and Conditions - Privacy
* These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure or prevent any disease. The information on this site is for educational purposes only and should not be considered medical advice. Please speak with an appropriate healthcare professional when evaluating any wellness related therapy. Please read the full medical disclaimer before taking any of the products offered on this site.
† note offer applies to first-time subscription orders only