Vit B12 (as Methylcobalamin)

Overview:
Methylcobalamin is a methylated and active form of vitamin b12 (cobalamin) with strong neuroprotective and anti-aging effects. Methylcobalamin’s effects include improved memory and executive function, as well as enhanced focus.

Scientific Name:
Methylcobalamin

Mechanisms:

  • Acts as a cofactor for a number of enzymes and provides functional support for neurons [1]

  • Improves neuronal regenerative capacity and reduces neurotoxicity [2]

  • Can decrease neuropathy and neuropathic pain [3]

  • Removes excessive homocysteine in the brain – main cause of vascular degeneration [1]

  • Upregulates S-adenosylmethionine production [4]

  • Improves memory, concentration, executive function, and motor control [5]

  • Prevents age-associated cognitive decline [6]

  • Anxiolytic effect [7]

References

[1] O’Leary F, Samman S (2010). Vitamin B12 in health and disease. Nutrients, 2(3):299-316. doi: 10.3390/nu2030299
[2] Kennedy DO (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients, 8(2):68. doi: 10.3390/nu8020068
[3] Zhang M, et al (2013). Methylcobalamin: a potential vitamin of pain killer. Neural Plast, 2013:424651. doi: 10.1155/2013/424651
[4] Tiemeier H, et al (2002). Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry, 159(12):2099-101. doi: 10.1176/appi.ajp.159.12.2099
[5] Rathod R, et al (2016). Novel insights into the effect of vitamin B₁₂ and omega-3 fatty acids on brain function. J Biomed Sci, 23:17. doi: 10.1186/s12929-016-0241-8
[6] Smith AD, Refsum H (2009). Vitamin B-12 and cognition in the elderly. Am J Clin Nutr, 89(2):707S-11S. doi: 10.3945/ajcn.2008.26947D
[7] Long SJ, Benton D (2013). Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. Psychosom Med, 75(2):144-53. doi: 10.1097/PSY.0b013e31827d5fbd