Niacin (as Niacinamide)

Overview:
Nicotinamide is the amide form of vitamin B3 (nicotinic acid / niacin) that is naturally synthesized in the body with neuroprotective and anti-inflammatory effects. Experimental evidence indicates that nicotinamide can decrease age-associated cognitive impairment.

Scientific Name:
Pyridine-3-carboxamide

Mechanisms:

  • Nicotinamide is part of two essential coenzymes for energy production and DNA repair – nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP)[1]
  • Anti-inflammatory activity[2]
  • Can prevent the death of cortical neurons exposed to oxidative agents[3]
  • Can have anxiolytic effects[4]
  • Inhibits the activity of sirtuins – proteins that play important roles in aging, cell death and inflammation – can decrease neurodegenerative and age-associated memory impairment[5]
References

[1] Belenky P, et al (2007). NAD+ metabolism in health and disease. Trends Biochem Sci, 32(1):12-9. doi: 10.1016/j.tibs.2006.11.006
[2] Niren NM (2006). Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review. Cutis, 77(1 Suppl):11-6. PMID: 16871774
[3] Hoane MR, et al (2006). Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain. Neurosci Lett, 408(1):35-9. doi: 10.1016/j.neulet.2006.07.011
[4] Möhler H et al (1979). Nicotinamide is a brain constituent with benzodiazepine-like actions. Nature, 278(5704):563-5. doi: 10.1038/278563a0
[5] Denu JM (2005). Vitamin B3 and sirtuin function. Trends Biochem Sci, 30(9):479-83. doi: 10.1016/j.tibs.2005.07.004