Vit B6 (as Pyridoxal-5-Phosphate)

Overview:
P-5-P is the most active form of vitamin B6, having significant nootropic effects. P-5-P plays an essential part in mood, memory formation, and executive functions.

Scientific Name:
(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate

Mechanisms:

  • Essential for cellular energy metabolism[1]
  • Increases mental and physical energy, improves neuronal communication[2]
  • Prevents age-associated neuronal damage[3]
  • Involved in the synthesis of acetylcholine, dopamine, serotonin, noradrenaline and melatonin[4,5]
  • Important role in executive functions, memory formation, mood regulation, focus, motivation, and sleep regulation[5,6]
References

[1] Clayton PT (2006). B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis, 29(2-3):317-26. doi: 10.1007/s10545-005-0243-2
[2] Ebadi M, et al (1990). Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions. Ann N Y Acad Sci, 585:189-201. doi: 10.1111/j.1749-6632.1990.tb28053.x
[3] Campanini B, et al (2013). Serine racemase: a key player in neuron activity and in neuropathologies. Front Biosci (Landmark Ed), 18:1112-28. doi: 10.2741/4167
[4] Yoshimura T, Goto M (2008). D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases. FEBS J, 275(14):3527-37. doi: 10.1111/j.1742-4658.2008.06516.x
[5] Deijen JB et al (1992). Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl), 109(4):489-96. doi: 10.1007/BF02247729
[6] Ebadi M (1981). Regulation and function of pyridoxal phosphate in CNS. Neurochem Int ;3(3-4):181-205. doi: 10.1016/0197-0186(81)90001-2