Getting the Most Out of DL-Phenylalanine (DLPA)

Getting the Most Out of DL-Phenylalanine (DLPA)

One of the biggest factors in living a healthy life is what we eat. Having a balanced diet gives us a better chance at including everything we need for our bodies to function properly. One class of nutrient often lacking in our diet is amino acids. Since amino acids build protein, it’s important that we have enough in our diets. We usually find amino acids in food sources such as beef, eggs, fish, legumes, nuts, and whole grains. Phenylalanine is an essential amino acid.  Sometimes, we do not have enough food that contains phenylalanine in our diet.  Individuals not getting enough essential amino acids should consider taking DL-phenylalanine as a dietary supplement. Dietary supplements can also be known as nutritional supplements.

What is DL-Phenylalanine?

DL-Phenylalanine (DLPA) is an amino acid supplement, a synthetic phenylalanine. Phenylalanine is a neutral,non-polar amino acid that plays a crucial role in many functions within the body. One of those functions is to produce tyrosine, a major component for synthesizing hormones. Phenylalanine also produces neurotransmitters in the body, including epinephrine, dopamine, and norepinephrine. Phenylalanine is a natural amino acid and found in many protein-rich foods. If you’re eating a chicken thigh, drinking milk, or chowing down on scrambled eggs, you’re getting phenylalanine in your diet. 

Phenylalanine is found in three different forms. The natural form, found in food, is also called L-phenylalanine. There’s also a synthetic form, D-phenylalanine, which is very similar to the natural version. Both of these forms come with their own unique benefits, but if you want to get the most out of  them, you’ll want to look at the third form: DL-phenylalanine. This form combines both the “L” and “D” forms, creating a supplement with the benefits of both types.

DL-Phenylalanine Benefits

Since DLPA brings a lot of benefits to the table, it’s worth getting to know what those benefits are. Here are a few that you  should pay close attention to.

Enhancing Your Mood

As noted above, phenylalanine is an important component in the production of neurotransmitters like dopamine and epinephrine. If your body generates more “feel good” hormones, this will have a positive impact on your mood. With DLPA, your body may also produce tyrosine, which  can also increase dopamine production. The more dopamine you have impacting your brain, the more likely you are to experience an overall enhanced mood, reduce pain and have greater feelings of happiness and fulfillment. People with a phenylalanine deficiency may be at risk for lower adrenaline and noradrenaline levels. The amount of phenylalanine you have can be very critical. DLPA may also help to produce more adrenaline and noradrenaline, which can help improve your energy level and motivation to work throughout the day. Taking DLPA may lead to an increased sense of self-worth, and a more positive outlook on life. If you have lower phenylalanine levels it may affect your mood.

Sharpening Your Mind

With more neurotransmitters in your system, you may experience some other important benefits as well. One of those benefits may include having a sharper mind and an increased amount of concentration.  Taking DLPA may also help to reduce brain fog. DLPA can bind to glutamate AMPA receptors in the brain, which sharpens the communication between the brain’s synapses, and results in enhanced memory and improved learning.

Helping With Your Pain

DLPA is also able to block the enkephalinase. This can lead to a relief from certain types of pain. DLPA can also play a big role in producing more opioids naturally within your body, which can also help with pain relief. Therefore, it could be a very beneficial health benefit. Though more research is needed, it’s an exciting possibility and could point to more uses for DLPA in the future. Research suggests that it could be very beneficial for low back pain as well.

Other Benefits

Early research indicates that DLPA could provide other benefits worth investigating. Some research shows that DLPA may be able to help with certain skin conditions like vitiligo. Once again it can be possibly effective. The more research that is done on the potential benefits of DLPA, the more we’ll learn about this supplement and the impact it can have on your life.

Taking DL-Phenylalanine

As always, consult with a doctor when adding DLPA to your supplement regimen. When looking at the most beneficial nootropics, make sure to include DLPA in your study. It’s an effective supplement with health solutions and benefits you won’t want to miss.


  • Eddie Quest
    "TAKING DL-PHENYLALANINE"... Consult someone else. Not much useful information there, guys.
  • Songhope
    Lots of useful info here. I've researched DLPA before and have taken it for a few years. I did not know about the pain connection, though. I'll add it to the list for my sister who's had Rheumatoid Arthritis for 3-4 years now. RA also has an effect on cognition, eventually. The systemic inflammation is the main contributor, so this will have dual benefit.
  • Michael Swanson
    The OP also fails to state that it is also lethal. Highly irresponsible if you ask me which makes any claims by the OP highly suspect.
  • David Kinard
    It is not highly lethal. What on earth are you talking about Michael Swanson? This was the the key element in resolving my long term treatment resistant depression.
  • Diane
    SONGHOPE, if you happen to come back here and see this, I'd like to share something I just stumbled on about rheumatoid arthritis. Maybe you already know it, but just in case... Here are a couple of quotes: "In 1975, at the IXth International Chemotherapy Congress in London, England, the late (1983) Roger Wybum-Mason (M.D., M.R.C.P., B. Chir., M.A., Ph.D.) astounded the medical world, announcing that he had found a new protozoon as the cause of Rheumatoid Disease." "When treating Rheumatoid Disease, one might expect as high as 30% of the patients to show temporary remissions due to unknown “placebo” effects. Roger was reporting results that were as high as 90%."
  • Michelle Lamont
    I have been taking DLPA (500mg) with Al-car (750mg) for around 4 months as i heard it would help with pain and braing fog. I have Hashimotos Thyroiditis and Fibromyalgia. I cannot say how helpful the DLPA has been for me. I feel normal. It eliminated my brain fog, reduced my pain and as a bonus increased my mood significantly. I ran out of DLPA recently and didn't think much about it but for about three weeks until my pain returned, my mood plumetted and brain fog was back. I had no idea how effective it actually was until it was gone. Three days back on it and I can already feel my mood lifting.
  • Cara
    Another benefit is as an appetite suppressant. I take 2x 1000mg capsules for effectiveness all day long.. . You can even take that dose twice a day -- as with all amino acids it MUST BE TAKEN ON AN EMPTY STOMACH WITH WATER OR JUICE -- NO PROTEIN. Otherwise your body just treats it as food & you lose the benefits. And I've taken the first dose for 6 months now -- 2000mg per day -- anyone who thinks it's highly lethal is highly loopy! NO side effects whatsoever except good ones! This is in fact one of the most beneficial amino acids.
  • Leslie H.
    They have people who respond with statements like Michael Swanson has to keep many away from true natural ways in battling issues as this. I like to look at it as G.O.D., Gods Original Design as we are of the Earth! With all the Elements, we need Balance and many people today are off balance. Their chemical balance cannot be balanced until they take (Bump Up) enough of what's need for their issue at hand. I pray that those who know can be providing a better awareness for those who are unaware and aren't sure. Leslie...
  • amanda thompson
    I just came across your site. Very helpful and interesting article. My doctor wants me to take DLPA and now I understand why. I have chronic pain from Lyme disease, brain fog, depression and fatigue. I've heard of the various amino acids, but didn't understand what they did and the differences. Thanks for explaining.
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