Getting the Most Out of DL-Phenylalanine (DLPA)

Getting the Most Out of DL-Phenylalanine (DLPA)

One of the biggest factors in living a healthy life is what we eat. Having a balanced diet gives us a better chance at including everything we need for our bodies to function properly. One class of nutrients often lacking in our diet is amino acids. Since amino acids build protein, it’s important that we have enough in our diets. We usually find amino acids in food sources such as beef, eggs, fish, legumes, nuts, and whole grains. Phenylalanine is an essential amino acid.  Sometimes, we do not have enough food that contains phenylalanine in our diet.  Individuals not getting enough essential amino acids should consider taking DL-phenylalanine as a dietary supplement. Dietary supplements can also be known as nutritional supplements.

What is DL-Phenylalanine?

DL-Phenylalanine (DLPA) is an amino acid supplement, a synthetic phenylalanine. Phenylalanine is a neutral,non-polar amino acid that plays a crucial role in many functions within the body. One of those functions is to produce tyrosine, a major component for synthesizing hormones. Phenylalanine also produces neurotransmitters in the body, including epinephrine, dopamine, and norepinephrine. Phenylalanine is a natural amino acid and found in many protein-rich foods. If you’re eating a chicken thigh, drinking milk, or chowing down on scrambled eggs, you’re getting phenylalanine in your diet. 

Phenylalanine is found in three different forms. The natural form, found in food, is also called L-phenylalanine. There’s also a synthetic form, D-phenylalanine, which is very similar to the natural version. Both of these forms come with their own unique benefits, but if you want to get the most out of them, you’ll want to look at the third form: DL-phenylalanine. This form combines both the “L” and “D” forms, creating a supplement with the benefits of both types.

DL-Phenylalanine Benefits

Since DLPA brings a lot of benefits to the table, it’s worth getting to know what those benefits are. Here are a few that you should pay close attention to.

Enhancing Your Mood

As noted above, phenylalanine is an important component in the production of neurotransmitters like dopamine and epinephrine. If your body generates more “feel good” hormones, this will have a positive impact on your mood. With DLPA, your body may also produce tyrosine, which can also increase dopamine production. The more dopamine you have impacting your brain, the more likely you are to experience an overall enhanced mood, reduce pain and have greater feelings of happiness and fulfillment. People with a phenylalanine deficiency may be at risk for lower adrenaline and noradrenaline levels. The amount of phenylalanine you have can be very critical. DLPA may also help to produce more adrenaline and noradrenaline, which can help improve your energy level and motivation to work throughout the day. Taking DLPA may lead to an increased sense of self-worth, and a more positive outlook on life. If you have lower phenylalanine levels it may affect your mood.

Sharpening Your Mind

With more neurotransmitters in your system, you may experience some other important benefits as well. One of those benefits may include having a sharper mind and an increased amount of concentration.  Taking DLPA may also help to reduce brain fog. DLPA can bind to glutamate AMPA receptors in the brain, which sharpens the communication between the brain’s synapses, and results in enhanced memory and improved learning.

Helping With Your Pain

DLPA is also able to block the enkephalinase. This can lead to a relief from certain types of pain. DLPA can also play a big role in producing more opioids naturally within your body, which can also help with pain relief. Therefore, it could be a very beneficial health benefit. Though more research is needed, it’s an exciting possibility and could point to more uses for DLPA in the future. Research suggests that it could be very beneficial for low back pain as well.

Other Benefits

Early research indicates that DLPA could provide other benefits worth investigating. Some research shows that DLPA may be able to help with certain skin conditions like vitiligo. Once again it can be possibly effective. The more research that is done on the potential benefits of DLPA, the more we’ll learn about this supplement and the impact it can have on your life.

Taking DL-Phenylalanine

As always, consult with a doctor when adding DLPA to your supplement regimen. When looking at the most beneficial nootropics, make sure to include DLPA in your study. It’s an effective supplement with health solutions and benefits you won’t want to miss.


  • Eddie Quest
    "TAKING DL-PHENYLALANINE"... Consult someone else. Not much useful information there, guys.
  • Songhope
    Lots of useful info here. I've researched DLPA before and have taken it for a few years. I did not know about the pain connection, though. I'll add it to the list for my sister who's had Rheumatoid Arthritis for 3-4 years now. RA also has an effect on cognition, eventually. The systemic inflammation is the main contributor, so this will have dual benefit.
  • Michael Swanson
    The OP also fails to state that it is also lethal. Highly irresponsible if you ask me which makes any claims by the OP highly suspect.
  • David Kinard
    It is not highly lethal. What on earth are you talking about Michael Swanson? This was the the key element in resolving my long term treatment resistant depression.
  • Diane
    SONGHOPE, if you happen to come back here and see this, I'd like to share something I just stumbled on about rheumatoid arthritis. Maybe you already know it, but just in case... Here are a couple of quotes: "In 1975, at the IXth International Chemotherapy Congress in London, England, the late (1983) Roger Wybum-Mason (M.D., M.R.C.P., B. Chir., M.A., Ph.D.) astounded the medical world, announcing that he had found a new protozoon as the cause of Rheumatoid Disease." "When treating Rheumatoid Disease, one might expect as high as 30% of the patients to show temporary remissions due to unknown “placebo” effects. Roger was reporting results that were as high as 90%."
  • Michelle Lamont
    I have been taking DLPA (500mg) with Al-car (750mg) for around 4 months as i heard it would help with pain and braing fog. I have Hashimotos Thyroiditis and Fibromyalgia. I cannot say how helpful the DLPA has been for me. I feel normal. It eliminated my brain fog, reduced my pain and as a bonus increased my mood significantly. I ran out of DLPA recently and didn't think much about it but for about three weeks until my pain returned, my mood plumetted and brain fog was back. I had no idea how effective it actually was until it was gone. Three days back on it and I can already feel my mood lifting.
  • Cara
    Another benefit is as an appetite suppressant. I take 2x 1000mg capsules for effectiveness all day long.. . You can even take that dose twice a day -- as with all amino acids it MUST BE TAKEN ON AN EMPTY STOMACH WITH WATER OR JUICE -- NO PROTEIN. Otherwise your body just treats it as food & you lose the benefits. And I've taken the first dose for 6 months now -- 2000mg per day -- anyone who thinks it's highly lethal is highly loopy! NO side effects whatsoever except good ones! This is in fact one of the most beneficial amino acids.
  • Leslie H.
    They have people who respond with statements like Michael Swanson has to keep many away from true natural ways in battling issues as this. I like to look at it as G.O.D., Gods Original Design as we are of the Earth! With all the Elements, we need Balance and many people today are off balance. Their chemical balance cannot be balanced until they take (Bump Up) enough of what's need for their issue at hand. I pray that those who know can be providing a better awareness for those who are unaware and aren't sure. Leslie...
  • amanda thompson
    I just came across your site. Very helpful and interesting article. My doctor wants me to take DLPA and now I understand why. I have chronic pain from Lyme disease, brain fog, depression and fatigue. I've heard of the various amino acids, but didn't understand what they did and the differences. Thanks for explaining.
  • Saska
    Any side effects with this one and what is the max per day to take? I have heard this acts on Dopamine gateways. I read about this supplement in Dr Kharrazians book 'Why is my brain not working'. He also has other great protocols mentioned for ppl with various health issues.
  • Saska
    Forgot to ask, has it helped ppl with concentration issues? Im having cognitive issues with for instance putting a plan together, my thoughts or thinking structure is all over the place. Did not have this years ago. I did go through 2 brain surgeries in the past, not sure if this plays a role, but wanted to know if this supp could help with it.
  • Saska
    Last comment, can one become resistant to this amino acid just like L-dopa in Parkinson's. eventually, your body gets used to it and stops working.
  • lori shindel
    Hi Saska - I can only give you my personal account based on years of figuring out what works in my own body and brain. Also - as you know - the body is dynamic, so as you try to find solutions over time you will learn what works when certain conditions are present, and not need to take a targeted supplement forever (unless you want to) like brain fog, depression, lack of motivation, etc. For me DLPA was huge in brain fog and depression, and the unexpected bonus of appetite suppression. I started with 2000mg /day, split into 2 doses, one in the am (alone) and one around noon (also on empty stomach). I stayed high dose for about 3 weeks, then went to 1000, and am now at 500mg in the am. I'll bump it up as needed, and will take breaks from it as well. Taking even a couple days off (over a weekend?) is never a bad idea unless it's a required daily medication. A good choline supplement helps cognition, as well as a good B complex (which you can double or triple the dose on the label to treat acute issues) and minerals like magnesium/zinc/selenium (not all taken together). I have not noticed any resistance buildup to DLPA after 3 months of taking it, but I do take a weekend here or there off, and 3 months is not long term. There are so many good supplements out there, but taking the time to see how each one works with your particular biochemistry will be what gives you success. They won't all work for you the way some websites say they will, but I can attest that the solutions for you are out there if you have patience and commitment to your own mental and physical health and are willing to try different things with an open mind. Good luck!
  • Dave Williams
    Hi. I served 21 years as a British Special Forces Soldier, mostly active (90%). I was suffering from severe PTSD particularly "Action Recall at Night" (Nightmares) and aggression, short tempered. Most of all excessive essential shakes, could not pour or hold a glass of wine one hand, or serve a coffee. Thanks to DLPA I am now a normal person (as normal as a ex soldier can be) more tolerant and forgiving, not everything is an emergency, shakes are gone to the extent not only can I pour wine but even put a new battery in my watches. DLPA saved my life.
  • Dave Williams
    Re the above. I only take 500mg per day and it took 60 days to solve my shaking problem. Mood improvement after 30 days. I will never take more than 500mg per day, not required for me. Fantastic.
  • Nici
    I've taken D-Phenylalanine for chronic pain, fibromyalgia, migraines & depression. I no longer get migraines! It has been helpful with chronic pain as well. I recently started back on a daily regiment for depression and will make sure to continue. Anyone wondering if it helps for depression and other conditions should check out The Mood Cure by Julia Ross. Thanks to all for positive feedback & experience sharing; I found it helpful & inspiring! We can heal ourselves...big pharma doesn't want that and will try to hinder any options of it. Research for yourself
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