Grapefruit Whole Fruit Extract




Support brain function*
Supports antioxidant defenses*
Supports cellular health*


Grapefruit (Citrus × paradisi) is a hybrid citrus fruit. One grapefruit ancestor is pomelo and the other is sweet orange—the × in the botanical name indicates its hybrid origin. Grapefruits are rich in antioxidants, including many of the same citrus bioflavonoids found in oranges. But it’s a flavonoid called naringin that (1) gives grapefruit its distinctive bitter taste, and (2) is why a grapefruit extract would be used rather than another citrus extract. Naringin, like all flavonoids, is part of a larger group of plant compounds called polyphenols.


Grapefruit Whole Fruit Extract contains not less than 20% naringin.

Grapefruit Whole Fruit Extract is Non-GMO and Vegan.


Many flavonoid molecules are part of plants’ protective responses to mild environmental stress. Because of this, we don’t think of flavonols (like naringin) as being “more is better” ingredients. Instead we think it’s better to use them following hormetic dosing principles (see Neurohacker Dosing Principles). One of our formulation goals is to support entire pathways. This means, among other things, identifying enzymes in the pathway that are important in ensuring the flow of molecules through the pathway. We then look for compounds that may have an ability to support these enzymes. We use a grapefruit extract standardized for naringin content, because of this enzyme-supportive function. But we only include a very low amount of naringin—about what would be found in ⅓ of an ounce of grapefruit juice—because we did not want to substantially influence the activity of the cytochrome P450 enzymes that naringin may influence. We can do this because of another goal in our formulation strategy. We endeavor to include more than one ingredient that may serve the same purpose, which allows us to include lower amounts of both ingredients (as opposed to higher amounts of just one). This concept of having more than one ingredient in a formula that has functionally similar purposes is why we feel comfortable with giving a very low amount of grapefruit extract.


Brain function
Supports learning and memory[1–3]
Supports healthy neurobehavioral responses to stress[1,2,4]
Slows adenosine deaminase (ADA)[5]
Downregulates acetylcholinesterase (AChE) activity[1,2,6,7]
Supports glutamine synthetase expression[8] and glutamate levels[6,8]
Supports GABA levels[6]
Supports dopamine levels[6]
Supports glia-derived neurotrophic factor (GDNF) levels[9]
Supports sleep processes[10]
Supports neuroprotective functions[1,6–8,11–16]
Supports free radical scavenging [6,8,11,14,15]
Supports neural antioxidant defenses[6,8,11,15]
Supports neural Nrf2 signaling[11]
Supports neural phase II detoxifying/antioxidant enzymes[11]
Supports neural immune signaling[4,11,15,16]
Supports neural mitochondrial function[3,7,12,14]
Supports neural autophagy/mitophagy[14,17]

Antioxidant defenses
Supports antioxidant defenses[11,18,19]
Supports free radical scavenging[20]
Counters oxidative stress and ROS production[11,18,19,21]
Supports Nrf2 signaling[11]
Supports phase II antioxidant enzymes[11,18]

Healthy aging and longevity
Supports mitochondrial function[21,22]
Supports healthy metabolic function[23]
Supports healthy cardiovascular function[23]
Supports healthy liver function[23]


[1] S.R. Maratha, N. Mahadevan, Neurochem. Res. 37 (2012) 2206–2212.
[2] B. Ben-Azu, E.E. Nwoke, A.O. Aderibigbe, I.A. Omogbiya, A.M. Ajayi, E.T. Olonode, S. Umukoro, E.O. Iwalewa, Biomed. Pharmacother. 109 (2019) 536–546.
[3] D. Wang, J. Yan, J. Chen, W. Wu, X. Zhu, Y. Wang, Cell. Mol. Neurobiol. 35 (2015) 1061–1071.
[4] M. Kwatra, A. Jangra, M. Mishra, Y. Sharma, S. Ahmed, P. Ghosh, V. Kumar, D. Vohora, R. Khanam, Neurochem. Res. 41 (2016) 2352–2366.
[5] G. Li, I. Nakagome, S. Hirono, T. Itoh, R. Fujiwara, Pharmacol Res Perspect 3 (2015) e00121.
[6] P.K. Kola, A. Akula, L.S. NissankaraRao, R.C.S.R. Danduga, Epilepsy Behav. 75 (2017) 114–126.
[7] A. Prakash, B. Shur, A. Kumar, Int. J. Neurosci. 123 (2013) 636–645.
[8] A. Ramakrishnan, N. Vijayakumar, M. Renuka, Biomed. Pharmacother. 84 (2016) 1717–1726.
[9] E. Leem, J.H. Nam, M.-T. Jeon, W.-H. Shin, S.-Y. Won, S.-J. Park, M.-S. Choi, B.K. Jin, U.J. Jung, S.R. Kim, J. Nutr. Biochem. 25 (2014) 801–806.
[10] S.P. Fernández, C. Wasowski, L.M. Loscalzo, R.E. Granger, G.A.R. Johnston, A.C. Paladini, M. Marder, Eur. J. Pharmacol. 539 (2006) 168–176.
[11] K. Gopinath, G. Sudhandiran, Neuroscience 227 (2012) 134–143.
[12] A.K. Sachdeva, A. Kuhad, K. Chopra, Pharmacol. Biochem. Behav. 127 (2014) 101–110.
[13] S. Qin, Q. Chen, H. Wu, C. Liu, J. Hu, D. Zhang, C. Xu, Brain Res. Bull. 124 (2016) 164–171.
[14] J. Feng, X. Chen, S. Lu, W. Li, D. Yang, W. Su, X. Wang, J. Shen, Mol. Neurobiol. 55 (2018) 9029–9042.
[15] J.-Y. Long, J.-M. Chen, Y.-J. Liao, Y.-J. Zhou, B.-Y. Liang, Y. Zhou, Behav. Brain Funct. 16 (2020) 4.[16] J. Yang, L. Yuan, Y. Wen, H. Zhou, W. Jiang, D. Xu, M. Wang, Med. Sci. Monit. 26 (2020) e918772.[17] K.H. Jeong, U.J. Jung, S.R. Kim, Evid. Based. Complement. Alternat. Med. 2015 (2015) 354326.
[18] M. Rajadurai, P. Stanely Mainzen Prince, Toxicology 228 (2006) 259–268.
[19] M.M. Ali, M.A.A. El Kader, Z. Naturforsch. C 59 (2004) 726–733.
[20] M. Cavia-Saiz, M.D. Busto, M.C. Pilar-Izquierdo, N. Ortega, M. Perez-Mateos, P. Muñiz, J. Sci. Food Agric. 90 (2010) 1238–1244.
[21] J. Chen, R. Guo, H. Yan, L. Tian, Q. You, S. Li, R. Huang, K. Wu, Basic Clin. Pharmacol. Toxicol. 114 (2014) 293–304.
[22] M. Rajadurai, P.S.M. Prince, J. Biochem. Mol. Toxicol. 21 (2007) 354–361.
[23] M.A. Alam, N. Subhan, M.M. Rahman, S.J. Uddin, H.M. Reza, S.D. Sarker, Adv. Nutr. 5 (2014) 404–417.