Palmitoylethanolamide

COMMON NAME

Palmitoylethanolamide | PEA | Palmidrol | Impulsin


TOP BENEFITS OF PALMITOYLETHANOLAMIDE

Supports general immune health*

Supports upper respiratory tract health*

Supports joint and muscle function and comfort*

Supports balanced mood*

Supports healthy sensory nerve signaling*


WHAT IS PALMITOYLETHANOLAMIDE?

Palmitoylethanolamide, abbreviated PEA, is an endogenous (i.e., manufactured by the body) fatty acid amide (FAA). It is found throughout the body and, like the other, endogenously produced FAA, is a signaling molecule, used in cellular communication. During times of stress or when the need for healing is greater, cells produce and use more palmitoylethanolamide. Its biological actions are primarily mediated by peroxisome proliferator-activated receptor alpha (PPAR-α) and endocannabinoid receptors[1,2]. Palmitoylethanolamide plays especially important functional roles in sensory nerves, and in supporting microglia (the brain’s immune cells), mast cells, macrophages, and overall immune system communication. Palmitoylethanolamide was researched as a way to support general immune health and wellness in the 1960’s and 1970’s. More recently, much of the research on palmitoylethanolamide has focused on sensory nerve health, mood support, joint comfort, and muscle recovery. Palmitoylethanolamide also supports the richness of gut microbiota (i.e., the gut-immune axis).*


NEUROHACKER’S PALMITOYLETHANOLAMIDE SOURCING

Palmitoylethanolamide is GRAS, non-GMO, gluten-free, and vegan.


PALMITOYLETHANOLAMIDE DOSING PRINCIPLES AND RATIONALE

Palmitoylethanolamide has been studied clinically over a fairly wide range of doses, with the common range being 300-1200 mg. Evidence suggests a threshold response (see Neurohacker Dosing Principles) when Palmitoylethanolamide is given by itself (i.e., much of the benefits occur within the lower end of the dosing range). The dose of palmitoylethanolamide used in a Neurohacker formulation can vary significantly depending upon what other ingredients it’s combined with and the intent of the formulation.*


PALMITOYLETHANOLAMIDE KEY MECHANISMS

Supports healthy immune function*

Supports general immune health [3–6]  

Supports innate immunity [7–10]

Supports adaptive immunity [11]

Supports immune tolerance [12–15]

Supports immune signaling [3,8,11,12]

Supports healthy microglia function [4,16–18]

Supports healthy macrophage function [7,8,10]

Supports healthy T cell function [11]

Supports healthy mast cell function [9,18–21]


Supports healthy gastrointestinal function* 

Supports GI immune signaling [22–24]

Supports gut barrier function [25,26]

Supports gut microbiota [27,28] 


Supports healthy brain and nerve function*

Supports brain function [29,30]

Supports neuroimmune signaling [12,18,32–34]

Supports sensory nervous system health [29,35,36]

Supports a positive mental-emotional bias [37]

Supports healthy behavioral and cognitive responses to stress [12,38–40]

Supports neuroprotection [32–34,41–43]

Supports neural antioxidant defenses [33]

Supports endogenous cannabinoid (i.e., endocannabinoid) signaling [12,38,39,44]

Supports TRPV1 signaling


Supports muscle and joint function*

Supports joint & muscle health, comfort and  flexibility [45,46]

Supports exercise recovery and performance [47]


Complementary ingredients*

Luteolin for brain, nerve and microglia function [13,48–51]


*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.


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