Fantastic experience, no side effects observed, even when taken on an empty stomach. I generally took the 2 pills in the mornings but did try a week where I'd take one in the morning, one at night. I tried Resilience for 30 days, 5 days on, 2 days off. Noticed a steady energy with less anxiety. Even typically stressful situations (plane travel, little sleep, conferences) felt less daunting. I need this for my future travels, especially!