Well, there were no negative effects but no noticeable positive effect for me either. I hate to give it only one star, because I like the company and have used some of their other products. But, for the short-term trial of SENOLYTIC, I just didn't see any change at all. Packaging, great. Service, great. Science? The ingredients might have had some apparent effect in prior trials/studies, but unfortunately, for me there was no effect.