Supports healthy aging*
Supports antioxidant defenses*
Supports cellular health*
Quercefit® is Indena’s unique Phytosome® formulation of quercetin. Some ingredients—quercetin is one of them—are very poorly absorbed. Indena’s Phytosome® technology creates a quercetin phytosome complex using sunflower lecithin, resulting in dramatically enhanced bioavailability* . The result, as Indena likes to say, is “Quercetin, made better.” But what is quercetin? Quercetin is a yellow plant pigment. Its name is derived from the Latin work for oak forest—quercetum—because it was originally identified in oaks. Quercetin is a flavonol, which is one of the polyphenol categories. Polyphenols play important roles in the plant kingdom. One of these roles is protecting plants from environmental stress such as pests and UV irradiation from the sun. Because of this role, they tend to concentrate in parts of the plant that come into more contact with the outside world. Red onions are one of the better food sources of quercetin. But the quercetin isn’t uniformly spread through red onions; it concentrates in the outer skins (which are usually thrown away when onions are peeled before use) and the part closest to the root. Capers may be the best dietary source of quercetin.
Quercefit® is a sunflower lecithin formulation of quercetin (Quercetin Phytosome®) containing 34-42% quercetin obtained from flower buds of Sophora japonica L.
Quercefit® has shown up to 20-fold more bioavailability than unformulated quercetin .
Quercefit® is a registered trademark of Indena S.p.A.
Quercefit® is non-GMO, gluten-free, and vegan.
We chose the recommended dose of Quercefit® taking into account several different factors. The primary factor was how quercetin in general, and Quercefit® specifically, are being dosed as a senolytic in clinical research. An example of this dosing is a planned clinical trial (ClinicalTrials.gov identifier NCT04313634) which is using a similar intermittent dosing protocol to what’s recommended for Qualia Senolytic. The trial is dosing Quercefit® at 1000 mg daily for several days. Our recommended dose selection also took into account that Qualia Senolytic contains several other ingredients which share some cellular function mechanisms with quercetin.* We opted for a slightly lower recommended daily dose of Quercefit® (750 mg per dose) to account for the contributions being made by these other ingredients.
Supports learning and memory [3–10]
Supports motor activity [6,8,11]
Supports non-rapid eye movement (non-REM) sleep 
Supports brain-derived neurotrophic factor (BDNF) [5,10,13–17]
Supports tryptophan hydroxylase (TPH) activity 
Supports serotonin synthesis/levels 
Downregulates MAO-A activity [8,18,19]
Downregulates acetylcholinesterase (AChE) activity [9,20,21]
Supports tyrosine hydroxylase (TH) activity 
Supports dopamine synthesis 
Supports noradrenaline synthesis 
Supports hippocampal SIRT1 levels 
Supports brain insulin signaling 
Supports long-term potentiation 
Supports neural stem/progenitor cell proliferation 
Supports neurogenesis 
Supports ectonucleotidase activity [21,24–26]
Downregulates adenosine deaminase (ADA) activity [21,25]
Supports neuroprotective functions [11,20,21,23,27–31]
Supports free radical scavenging [5,6,9,20,21,28,32]
Supports brain antioxidant defenses [5–7,9,20,28]
Supports Nrf2 signaling [7,29]
Supports phase II detox enzymes [7,29]
Supports brain mitochondrial function [4,29]
Supports neural AMPK signaling [4,27,29]
Supports healthy behavioral and physiological responses to stress [6,9,13,17,22,31–36]
Supports the composition of the gut microbiota [15,37–42]
Supports gut microbial metabolism 
Supports gut-immune communication [37,39]
Healthy aging and longevity*
Supports stem cell proliferation [10,43–45]
Supports stem cell differentiation [44–46]
Supports the management of senescent cells [43,47,48]
Supports cellular functions involved with pruning stressed cells [49–56]
Supports autophagy [57–63]
Supports mitophagy [48,64–66]
Influences PI3K/AKT signaling [54,67,68]
Influences mTOR signaling [57,61]
Influences AMPK signaling [69,70]
Influences SIRT1 signaling [48,60,64,70]
Influences NF-κB signaling 
Influences HIF-1α signaling [57,67–69,71]
Supports adaptive immunity 
Supports immune system communication 
Supports joint health 
Supports muscle recovery and contraction [74,75]
With palmitoylethanolamide for joint health 
With glucosamine and chondroitin for joint health 
With Mangifera indica leaf extract for ergogenic support 
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
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