Saffron | Saffron Crocus
Supports cognitive function*
Saffron is a spice derived from the flowers of Crocus sativus. It’s been used and traded as a spice for at least 4000 years and is considered the world's most costly spice by weight. Saffron has had a wide range and long list of traditional uses. In Traditional Iranian Medicine saffron was thought to be useful for supporting sleep and mood, and to be a heart tonic. And in India it was used as a nerve and heart tonic, and for relaxation and sleep support. Iran produces the majority of saffron: Greece, Kashmir, Morocco, Spain and Turkey are also fairly large growers. Saffron, as a spice, refers to the deep red-maroon colored stigma and styles (called threads). Not all saffron is of the same quality and strength, with price increasing substantially for the highest grades. In general, content of several of saffron’s active compounds are used to determine strength. A greater content of crocin (responsible for saffron's color), picrocrocin (a bitter compound giving the characteristic taste), and safranal (which gives the fragrance) would be graded as higher strength. In addition to these marker compounds, saffron also contains zeaxanthin, lycopene, and other carotenoids. Crocin also belongs to the carotenoid family. Most carotenoids only dissolve in oil (i.e., are fat-soluble). Crocin is water-soluble, which is part of the reason it is used in rice dishes and other water-based food recipes. There’s been a growing interest in the use of saffron for health purposes, including in areas such as mood, cognition, vision, sports performance, appetite regulation, metabolic function, sleep, and women’s health.*
There's a long history of saffron adulteration. Because of this, Neurohacker feels it is critical to use a standardized saffron extract purchased from an ingredient supplier that can authenticate quality and strength.
The saffron extract we use has been clinically studied, is DNA authenticated, and has a patented profile for marker compounds including crocin, picrocrocin and safranal.
Saffron extract used in our products is GRAS, non-GMO, gluten-free, vegan, Kosher certified and Halal compliant.
Most saffron studies have used standardized extracts, with doses typically in the range of 20-30 mg per day. While a few studies have used 60 mg, in general, we consider 30 mg to be at the top end of what’s needed when using saffron extracts for specific clinical reasons. Since studies comparing multiple doses or different standardizations have not been published, there’s no information on whether saffron has a threshold effect (i.e., an amount or range less than the full dose where the majority of the response would occur; see Neurohacker Dosing Principles). However, individual (i.e. N of 1) subjective response to saffron does vary considerably, with some persons reporting noticeable differences when taking as little as 1-3 mg of a standardized saffron extract. Depending on the purpose Neurohacker is using saffron for, and the other ingredients it’s combined with, it might be dosed anywhere ranging from a more micro-dose level up (3 mg) up to a studied dose of 30 mg per day.*
Supports a healthy mood*
Supports a positive mental-emotional bias [1–9]
Supports a calm mood [3,4,7–9]
Supports brain function*
Supports focus and attention 
Supports healthy brain aging [11–13]
Supports sleep [14–16]
Supports dopamine signaling [17,18]
Supports GABA-glutamate signaling 
Supports acetylcholinesterase activity 
Supports brain-derived neurotrophic factor (BDNF) levels [19,20]
Supports neuroprotective functions [18,21–25]
Supports long-term potentiation 
Supports healthy retinal function [22,26–33]
Supports macular health [27,30,33]
Supports visual acuity [30,33]
Supports protection of retinal cells from light-induced damage [28,34–36]
Supports healthy intraocular pressure 
Promotes exercise performance*
Supports reaction times 
Supports muscle strength 
Supports muscle recovery functions 
Supports antioxidant defenses*
Supports antioxidant enzymes [18,21,32]
Supports the replenishment of glutathione (GSH) levels [18,32]
Supports free-radical scavenging [18,21,31,32]
Supports healthy prooxidant-antioxidant balance 
Supports mitochondrial function*
Supports the activity of mitochondrial enzymes 
Supports mitochondrial membrane potential 
Supports healthy metabolic function*
Supports cytokine balance 
Supports appetite regulation 
Supports healthy lipid levels and blood pressure regulation [43,44]
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, or prevent any disease.
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