Ashwagandha | Indian ginseng
Supports a healthy stress response*
Supports exercise performance and energy*
Supports healthy weight*
Supports mitochondrial efficiency*
Supports brain function and mental cognition*
Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.
Sensoril® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.
Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.
Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).
Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status).
Vegetarian ● Organic compliant or certified organic ● Non-GMO Allergen & Gluten-free ● Kosher & Halal certified
We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold response in a study that gave different daily dosages—125 mg, 250 mg, and 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose. We opted for this lower dose to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.
Mitochondrial structure and function
Supports mitochondrial membrane potential and structural integrity 
Protects from mitochondrial damage 
Protects from mitochondrial membrane permeabilization 
Protects from complex I-V Inhibition (protects electron transport chain and oxidative phosphorylation performance) [2,4–6]
Upregulates citric acid cycle enzymes 
Supports endurance performance [7,8]
Supports muscle strength [9,10]
Supports post-exercise recovery 
Supports healthy insulin sensitivity [11–15]
Supports healthy blood glucose levels [12–16]
Supports healthy leptin signaling [11,15]
Supports healthy body weight [11,15]
Supports healthy feeding behaviors [11,17]
Supports lean mass 
Supports antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [2,4,5,16,18]
Replenishes glutathione (GSH) levels [2,4,16]
Counters oxidative stress and reactive oxygen species levels [2–4,19]
Influences the expression of immune signaling molecules [11–13]
Supports cognitive and psychomotor performance [20,21]
Supports memory, executive function, attention, and information processing speed 
Modulates GABAergic neurotransmission [23,24]
GABA receptor agonism [25–27]
Supports dopamine levels 
Influences the basal activity levels of acetylcholine esterase 
Supports neuroprotective functions [2,4,5]
Influences neural cytokine signaling 
Shortens sleep onset latency [23,28]
Supports sleep efficiency 
Supports quality of sleep [9,28]
Extends the duration of slow wave sleep 
Extends total sleep time 
Mood and stress response
Supports a calm mood [11,28]
Supports stress management [1,17,29]
Downregulates serum cortisol levels [1,17,29]
Supports thyroid function [30–32]
Healthy aging and longevity
Supports lifespan extension (Caenorhabditis elegans) [19,33]
Supports insulin-like growth factor-1 (IGF-1) signaling pathway [19,33]
Influences α-synuclein and amyloid-β aggregation 
Supports FOXO3A and SIRT3 
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