Sensoril® Ashwagandha Withania somnifera Root and Leaf Extract

Common Name

Ashwagandha | Indian ginseng

Top Benefits of Sensoril® Ashwagandha

Supports a healthy stress response*

Supports exercise performance and energy*

Supports healthy weight* 

Supports mitochondrial efficiency* 

Supports brain function and mental cognition* 

Supports sleep*

What is Sensoril® Ashwagandha?

Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.

Neurohacker’s Sensoril® Ashwagandha Sourcing

Sensoril® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.

Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.

Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).

Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status). 

Vegetarian ● Organic compliant or certified organic ● Non-GMO Allergen & Gluten-free ● Kosher & Halal certified

Sensoril® Ashwagandha Dosing Principles and Rationale

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold response in a study that gave different daily dosages—125 mg, 250 mg, and 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose.[1] We opted for this lower dose to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.

Withania somnifera Key Mechanisms 

Mitochondrial structure and function

Supports mitochondrial membrane potential and structural integrity [2]

Protects from mitochondrial damage [2]

Protects from mitochondrial membrane permeabilization [3]

Protects from complex I-V Inhibition (protects electron transport chain and oxidative phosphorylation performance) [2,4–6]

Upregulates citric acid cycle enzymes [6]


Exercise performance

Supports endurance performance [7,8]

Supports muscle strength [9,10]

Supports post-exercise recovery [10]


Metabolism

Supports healthy insulin sensitivity [11–15]

Supports healthy blood glucose levels [12–16]

Supports healthy leptin signaling [11,15]


Body weight 

Supports healthy body weight [11,15]

Supports healthy feeding behaviors [11,17]

Supports lean mass [10]


Antioxidant defenses

Supports antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [2,4,5,16,18]

Replenishes glutathione (GSH) levels [2,4,16]

Counters oxidative stress and reactive oxygen species levels [2–4,19]


Cellular signaling 

Influences the expression of immune signaling molecules [11–13]


Brain function

Supports cognitive and psychomotor performance [20,21]

Supports memory, executive function, attention, and information processing speed [22]

Modulates GABAergic neurotransmission [23,24]

GABA receptor agonism [25–27] 

Supports dopamine levels [4]

Influences the basal activity levels of acetylcholine esterase [4]

Supports neuroprotective functions [2,4,5]

Influences neural cytokine signaling [11]


Sleep

Shortens sleep onset latency [23,28]

Supports sleep efficiency [28]

Supports quality of sleep [9,28]

Extends the duration of slow wave sleep [23]

Extends total sleep time [23]


Mood and stress response

Supports a calm mood [11,28]

Supports stress management [1,17,29]

Downregulates serum cortisol levels [1,17,29]


Thyroid function

Supports thyroid function [30–32]


Healthy aging and longevity 

Supports lifespan extension (Caenorhabditis elegans) [19,33]

Supports insulin-like growth factor-1 (IGF-1) signaling pathway [19,33]

Influences α-synuclein and amyloid-β aggregation [19]

Supports FOXO3A and SIRT3 [34]


REFERENCES

[1]B. Auddy, J. Hazra, A. Mitra, B. Abedon, S. Ghosal, Journal of American Nutraceutical Association 11 (2008) 50–56.

[2]A. Sood, A. Mehrotra, D.K. Dhawan, R. Sandhir, Metab. Brain Dis. 33 (2018) 1261–1274.

[3]P. Parihar, R. Shetty, P. Ghafourifar, M.S. Parihar, Cell. Mol. Biol. 62 (2016) 73–83.

[4]M.J. Manjunath, Muralidhara, J. Food Sci. Technol. 52 (2015) 1971–1981.

[5]P. Kumar, A. Kumar, J. Med. Food 12 (2009) 591–600.

[6]P. Senthilnathan, R. Padmavathi, V. Magesh, D. Sakthisekaran, Life Sci. 78 (2006) 1010–1014.

[7]J.S. Sandhu, B. Shah, S. Shenoy, S. Chauhan, G.S. Lavekar, M.M. Padhi, Int. J. Ayurveda Res. 1 (2010) 144–149.

[8]B. Choudhary, A. Shetty, D.G. Langade, Ayu 36 (2015) 63–68.

[9]A.A. Raut, N.N. Rege, F.M. Tadvi, P.V. Solanki, K.R. Kene, S.G. Shirolkar, S.N. Pandey, R.A. Vaidya, A.B. Vaidya, J. Ayurveda Integr. Med. 3 (2012) 111–114.

[10]S. Wankhede, D. Langade, K. Joshi, S.R. Sinha, S. Bhattacharyya, J. Int. Soc. Sports Nutr. 12 (2015) 43.

[11]T. Kaur, G. Kaur, J. Neuroinflammation 14 (2017) 201.

[12]M.R. Shahraki, Z. Samadi Noshahr, H. Ahmadvand, A. Nakhaie, J. Basic Clin. Physiol. Pharmacol. 27 (2016) 387–391.

[13]Z. Samadi Noshahr, M.R. Shahraki, H. Ahmadvand, D. Nourabadi, A. Nakhaei, Rep Biochem Mol Biol 3 (2015) 62–67.

[14]T. Anwer, M. Sharma, K.K. Pillai, M. Iqbal, Basic Clin. Pharmacol. Toxicol. 102 (2008) 498–503.

[15]J. Lee, J. Liu, X. Feng, M.A. Salazar Hernández, P. Mucka, D. Ibi, J.W. Choi, U. Ozcan, Nat. Med. 22 (2016) 1023–1032.

[16]T. Anwer, M. Sharma, K.K. Pillai, G. Khan, Acta Pol. Pharm. 69 (2012) 1095–1101.

[17]D. Choudhary, S. Bhattacharyya, K. Joshi, J. Evid. Based Complementary Altern. Med. 22 (2017) 96–106.

[18]S.K. Gupta, A. Dua, B.P.S. Vohra, Drug Metabol. Drug Interact. 19 (2003) 211–222.

[19]B.A. Akhoon, S. Pandey, S. Tiwari, R. Pandey, Exp. Gerontol. 78 (2016) 47–56.

[20]U. Pingali, R. Pilli, N. Fatima, Pharmacognosy Res. 6 (2014) 12–18.

[21]K.N.R. Chengappa, C.R. Bowie, P.J. Schlicht, D. Fleet, J.S. Brar, R. Jindal, J. Clin. Psychiatry 74 (2013) 1076–1083.

[22]D. Choudhary, S. Bhattacharyya, S. Bose, J. Diet. Suppl. 14 (2017) 599–612.

[23]A. Kumar, H. Kalonia, Indian J. Pharm. Sci. 70 (2008) 806–810.

[24]M. Candelario, E. Cuellar, J.M. Reyes-Ruiz, N. Darabedian, Z. Feimeng, R. Miledi, A. Russo-Neustadt, A. Limon, J. Ethnopharmacol. 171 (2015) 264–272.

[25]A.K. Mehta, P. Binkley, S.S. Gandhi, M.K. Ticku, Indian J. Med. Res. 94 (1991) 312–315.

[26]J.P. Bhattarai, S.A. Park, S.K. Han, Phytotherapy Research (2009).

[27]H. Yin, D.H. Cho, S.J. Park, S.K. Han, The American Journal of Chinese Medicine 41 (2013) 1043–1051.

[28]D. Langade, S. Kanchi, J. Salve, K. Debnath, D. Ambegaokar, Cureus 11 (2019) e5797.

[29]K. Chandrasekhar, J. Kapoor, S. Anishetty, Indian J. Psychol. Med. 34 (2012) 255–262.

[30]A.K. Sharma, I. Basu, S. Singh, J. Altern. Complement. Med. 24 (2018) 243–248.

[31]J.M. Gannon, P.E. Forrest, K.N. Roy Chengappa, J. Ayurveda Integr. Med. 5 (2014) 241–245.

[32]R. Jatwa, A. Kar, Phytother. Res. 23 (2009) 1140–1145.

[33]B.A. Akhoon, L. Rathor, R. Pandey, Exp. Gerontol. 104 (2018) 113–117.

[34]R. Pradhan, R. Kumar, S. Shekhar, N. Rai, A. Ambashtha, J. Banerjee, M. Pathak, S.N. Dwivedi, S. Dey, A.B. Dey, Exp. Gerontol. 95 (2017) 9–15.