Uridine Monophosphate

Overview:
Uridine is a naturally occurring nucleic acid that plays a key role in many different neuroregulatory processes. It is believed to support short and long term memory, learning, attention, and executive function.

Mechanisms:
  • Uridine plays a key role in phospholipid synthesis, critical for cell membrane integrity[1]
  • Acts as a novel endogenous neurotransmitter via purinergic receptors[2]
  • Neuroprotective via its interaction with NGF and other integrins and growth factors
  • Supports synaptogenesis and neuroplasticity through increasing cerebral phosphatidylcholine levels needed to create dendrite membranes[3]
  • Elevates dopamine without downregulation[4]
  • Building block of RNA[2]
  • Involved in long term potentiation which mediates memory and learning
  • Found in high amounts in human breast milk[5]
  • Synergistic with choline donors, DHA, and other phospholipids[6]

More Info:
References:

[1] Richardson UI, et al (2003). Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. Brain Res, 971(2):161-7. doi: 10.1016/S0006-8993(03)02333-3 [2] Dobolyi A, et al (2011). Uridine function in the central nervous system. Curr Top Med Chem, 11(8):1058-67. doi: 10.2174/156802611795347618 [3] Wurtman RJ, et al (2010). Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. Nutr Rev, 68 Suppl 2:S88-101. doi: 10.1111/j.1753-4887.2010.00344.x [4] Wang L, et al (2005). Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci, 27(1):137-45. doi: 10.1385/JMN:27:1:137 [5] Thorell L, et al (1996). Nucleotides in human milk: sources and metabolism by the newborn infant. Pediatr Res, 40(6):845-52. doi: 10.1203/00006450-199612000-00012 [6] Cansev M, et al (2005). Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res, 1058(1-2):101-8. doi: 10.1016/j.brainres.2005.07.054