Vitamin B5 (Calcium Pantothenate)

Pantothenic acid (vitamin B5) is part of the B complex—a group of water-soluble vitamins that play important roles in cellular metabolism and energy production. It is an essential vitamin and the precursor of Coenzyme A (CoA), a molecule that is ubiquitous in the human body and that participates in the key metabolic pathways for cellular energy generation. CoA is also used in the synthesis of the neurotransmitter acetylcholine and is therefore essential for proper nervous system function. Vitamin B5 supports healthy adrenal function, which is why it is sometimes described as an “anti-stress” vitamin.*

Top Benefits of Calcium Pantothenate

Supports energy metabolism*

Supports brain function*

Neurohacker’s Calcium Pantothenate Sourcing

Calcium pantothenate—the calcium salt of pantothenic acid—is used in dietary supplements, because it’s shown to be more stable than pantothenic acid.

Calcium pantothenate sourcing is focused on identifying and purchasing from a reputable supplier and ensuring it’s a NON-GMO, gluten-free and vegan ingredient.

Calcium Pantothenate Formulating Principle and Rationale

Vitamin B5 generally has a wide serving range, however, from our interpretation of the research, we consider it to be subject to a threshold (see Neurohacker Dosing Principles), which means, while more might be better within a range, increasing amounts beyond that is unlikely to add significant additional nutritional or functional benefits for most people. Our goal in formulating products is to make sure that pantothenic acid amounts will be within this threshold range, even if several of our products with vitamin B5 are used together. In general, we tend to include a recommended serving of vitamin B5 at higher amounts in formulations where it would be used to support neurotransmitter production, and lower levels when we are using it to complement a full B complex stack.*

Calcium Pantothenate Key Mechanisms 

Vitamin B5 is required for the synthesis of coenzyme A (CoA)* [1]

Coenzyme A is a cofactor in several important cellular metabolic pathways* [2]

Coenzyme A has a key role in energy metabolism, especially the conversion of sugars and fats into energy* [3]

Coenzyme A is required for the synthesis of the neurotransmitter acetylcholine* [4]

Vitamin B5 supports healthy adrenal function* [5–11]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

[1]A.G. Tahiliani, C.J. Beinlich, in: G.D. Aurbach (Ed.), Vitamins & Hormones, Academic Press, 1991, pp. 165–228.

[2]R. Leonardi, Y.-M. Zhang, C.O. Rock, S. Jackowski, Prog. Lipid Res. 44 (2005) 125–153.

[3]F. Pietrocola, L. Galluzzi, J.M. Bravo-San Pedro, F. Madeo, G. Kroemer, Cell Metab. 21 (2015) 805–821.

[4]S.K. Fisher, S. Wonnacott, in: S.T. Brady, G.J. Siegel, R.W. Albers, D.L. Price (Eds.), Basic Neurochemistry (Eighth Edition), Academic Press, New York, 2012, pp. 258–282.

[5]L. Pan, S. Jaroenporn, T. Yamamoto, K. Nagaoka, I. Azumano, M. Onda, G. Watanabe, K. Taya, Reprod. Med. Biol. 11 (2012) 101–104.

[6]S. Jaroenporn, T. Yamamoto, A. Itabashi, K. Nakamura, I. Azumano, G. Watanabe, K. Taya, Biol. Pharm. Bull. 31 (2008) 1205–1208.

[7]P.E. Schwabedal, K. Pietrzik, W. Wittkowski, Cardiology 72 Suppl 1 (1985) 187–189.

[8]K. Pietrzik, C. Hesse, D. Hötzel, Int. J. Vitam. Nutr. Res. 45 (1975) 251–261.

[9]B.B. Longwell, A.E. Reif, E. Hansbury, Endocrinology 62 (1958) 565–572.

[10]A.B. Eisenstein, Endocrinology 60 (1957) 298–302.

[11]E.P. Ralli, M.E. Dumm, Vitam. Horm. 11 (1953) 133–158.