Grape Pomace Extract
BioVin® is made from the juice, seeds, and skins of French red grapes. It provides a full spectrum of grape’s health-promoting compounds. Grape skins and seeds contain small amount of trans-resveratrol. This compound has been the subject of hundreds or pre-clinical and clinical research studies. While trans-resveratrol has received a great deal of research attention, grapes are more than one compound: They contain resveratrol derivatives (e.g., viniferins, polydatin) and polyphenol compounds (e.g., oligomeric proanthocyanidins, quercetin, gallic acids, catechins). These compounds have synergies with trans-resveratrol. We think it makes sense to use a full spectrum extract to capture these synergies.
BioVin® is a full spectrum French red grape extract made from grape juice, seeds, and skins of Vitis vinifera, whole red grapes.
Standardized to contain 5% trans-resveratrol and not less than 40% grape oligomeric proanthocyanidins.
BioVin® is from grapes responsibly grown and harvested in the Rhone Valley region of France.
Non-GMO, Vegan
BioVin® Advanced is a registered trademark of Cyvex Nutrition, Inc dba Bioriginal.
When thinking about the dose of BioVin® there’s a few things to keep in mind. This grape extract has been standardized to contain 5% trans-resveratrol and not less than 40% oligomeric proanthocyanidins. The extract also has other compounds that naturally occur in grape juice, seeds, and skin. While trans-resveratrol is one of the reasons we use this extract, it’s the synergy of all of grape’s phytonutrients that is the story. Focusing only on the trans-resveratrol content misses the big picture. That said, we don’t view trans-resveratrol as a more is better compound. It might be better thought of as a hormetic substance; something that in low to moderate amounts helps promote an adaptive response to stress, but which doesn’t work as well at very high doses (see Neurohacker Dosing Principles). Our goal with trans-resveratrol, as with all many ingredient choices, is to select the lowest dose needed to produce desired benefits, especially in the context of other ingredient synergies. Studies have used resveratrol alone in doses as low as 10 mg … and doses of several grams. When used as part of a grape extract, the amount of resveratrol in the study has typically been less than 10 mg. When we choose our BioVin® dose the goal was to be at or above the low-dose resveratrol threshold, which we think of as being 10 mg. This allows us to also provide a meaningful dose of 80 mg per serving of oligomeric proanthocyanidins.
Grape proanthocyanidins
Mitochondrial biogenesis
Mitochondrial structure and function
Signaling pathways
Antioxidant defenses
Cellular signaling
Metabolism
Body weight
Exercise performance
Cognitive function
Mood and stress response
Brain function
Neuroprotection
Cardiovascular function
Gut microbiota
Skin health
Healthy aging and longevity
Other
Synergies
Resveratrol
Mitochondrial biogenesis
Mitochondrial structure and function
Signaling pathways
Antioxidant defenses
Insulin signaling
Body weight
Exercise performance
Cardiovascular function
Brain function
Cognitive function
Gut microbiota
Skin health
Healthy aging and longevity
Circadian rhythms
Synergies
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