Sirtmax® Kaempferia parviflora

Sirtmax® Kaempferia parviflora
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Kaempferia parviflora Common Name

Black Ginger | Black Turmeric | Krachai Dam

Top Benefits of Kaempferia parviflora

  • Supports mitochondrial biogenesis, structure and function*
  • Supports muscle strength and endurance*
  • Supports metabolism & healthy blood sugar levels*
  • Supports healthy weight*
  • Supports antioxidant defenses*
  • Supports healthy aging*
  • Support cardiovascular function*
  • Supports brain function*
  • Supports reproductive health*

What is Kaempferia parviflora?

Kaempferia parviflora is found in the upper Northeastern regions of Thailand. Root extracts have a long history of use and a reputation for being a health tonic and energy enhancer (i.e., Thai ginseng). The novel active constituents are a special type of polyphenol called polymethoxyflavonoids. Sirtmax® Kaempferia parviflora root extract is standardized for polymethoxyflavonoid content.

Neurohacker’s Kaempferia parviflora Sourcing

Sirtmax® has been used in animal and human research studies.

Created by Tokiwa Phytochemicals, a leader in standardized Kaempferia parviflora supplementation. 

Highest concentration, full-spectrum root extract, with double standardization for 5,7-dimethoxyflavone (≥ 4%) along with five Kaempferia parviflora polymethoxyflavonoids (≥ 15%).

Grown in Thailand & Laos.

Sirtmax® is a registered trademark of Tokiwa Phytochemical Co., Ltd.

Kaempferia parviflora Dosing Principles and Rationale

We consider Kaempferia parviflora to be in the adaptogenic herb category; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected to dose this at an amount that is within the studied range in humans.*

Kaempferia parviflora Key Mechanisms

Mitochondrial biogenesis

  • Upregulates mitochondrial number 1
  • Upregulates Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1alpha (PGC-1α) 1–3
  • Upregulates transcription factors for mitochondrial biogenesis (estrogen-related receptor-α [ERRα], nuclear respiratory factor-1 [Nrf-1], and mitochondrial transcription factor A [TFAM]) through activation of PGC-1α 2

Mitochondrial function

  • Upregulates AMP-Activated Protein Kinase (AMPK) 2,3
  • Promotes ATP production (output of mitochondrial oxidative phosphorylation) 3
  • Promotes mitochondrial β-oxidation (fatty acid metabolism) – upregulates peroxisome proliferator-activated receptor gamma (PPARγ) and delta (PPARδ)  2,4

Exercise performance (ergogenic effects)

  • Supports endurance performance 1,2,5,6
  • Supports post-exercise recovery 1
  • Supports muscle strength 5,6
  • Supports muscle metabolism (upregulates glycogen synthase and increases glycogen content) 1

Metabolism

  • Supports healthy insulin sensitivity 7
  • Promotes cell metabolism (muscle cell precursors [myoblasts] in vitro): promotes glucose uptake and the downregulation of lactic acid production; promotes the expression of glucose transporter 4 (GLUT4) and monocarboxylate transporter 1 (MCT1) 3

Body weight

  • Downregulates fat accumulation and blood/liver lipid levels 4,7,8
  • Promotes differentiation of brown adipocyte cells 4
  • Upregulates uncoupling protein 1 (UCP1) in brown adipose tissue - supports thermogenesis of brown adipose tissue  4,7,8
  • Promotes whole-body energy expenditure through activation of brown adipose tissue 7,9
  • Promotes lean body mass 2

Antioxidant defenses

  • Upregulates antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) 5

Healthy aging and longevity 

  • Upregulates SIRT-1 2,10
  • Downregulates the production of advanced glycation end-products (AGEs) 10

Cardiovascular function

  • Promotes healthy nitric oxide (NO) signaling pathway function 11–14
  • Upregulates endothelial NO synthase (eNOS) 11
  • Inhibits phosphodiesterase 5 (PDE-5), the enzyme that cleaves the NO mediator cyclic guanosine monophosphate (cGMP) to 5’GMP 15
  • Positive effect on NO signaling pathway in cardiac tissue via upregulated cGMP levels 12
  • Promotes vasodilation via the NO signaling pathway 13,14

Brain function

  • Acetylcholinesterase inhibition (by the methoxyflavonoid 5,7-dimethoxyflavone [DMF]) 16
  • Neuroprotection from glutamate excitotoxicity (by the methoxyflavonoid 5‐Hydroxy‐3,7,3′,4′‐tetramethoxyflavone)17

Reproductive function

  • Inhibits phosphodiesterase-5 (PDE-5)15 and supports relaxation of the corpus cavernosum 18

REFERENCES

1. Toda K, et al. Heliyon. 2016;2(5):e00115. doi:10.1016/j.heliyon.2016.e00115
2. Kim M-B, et al. J Med Food. 2018;21(1):30-38. doi:10.1089/jmf.2017.3989
3. Toda K, et al. J Nat Med. 2016;70(2):163-172. doi:10.1007/s11418-015-0948-y
4. Kobayashi H, et al. J Nat Med. 2016;70(1):54-61. doi:10.1007/s11418-015-0936-2
5. Wattanathorn J, et al. Evid Based Complement Alternat Med. 2012;2012:732816. doi:10.1155/2012/732816
6. Promthep K, et al. Med Sci Monit Basic Res. 2015;21:100-108. doi:10.12659/MSMBR.894301
7. Shimada T, et al. Fitoterapia. 2011;82(8):1272-1278. doi:10.1016/j.fitote.2011.08.018
8. Yoshino S, et al. Food Sci Nutr. 2014;2(6):634-637. doi:10.1002/fsn3.144
9. Matsushita M, et al. J Nutr Sci Vitaminol . 2015;61(1):79-83. doi:10.3177/jnsv.61.79
10. Nakata A, et al. Nat Prod Commun. 2014;9(9):1291-1294. PMID: 25918795.
11. Wattanapitayakul SK, et al. J Ethnopharmacol. 2007;110(3):559-562. doi:10.1016/j.jep.2006.09.037
12. Weerateerangkul P, et al. J Cardiovasc Pharmacol. 2012;60(3):299-309. doi:10.1097/FJC.0b013e3182609a52
13. Tep-Areenan P, et al. Phytother Res. 2010;24(10):1520-1525. doi:10.1002/ptr.3164
14. Tep-Areenan P, et al. Asian Biomed. 2010;4(1):103-111. doi:10.2478/abm-2010-0012
15. Temkitthawon P, et al. J Ethnopharmacol. 2011;137(3):1437-1441. doi:10.1016/j.jep.2011.08.025
16. Sawasdee P, et al. Phytother Res. 2009;23(12):1792-1794. doi:10.1002/ptr.2858
17. Moon H-I, et al. Phytother Res. 2011;25(8):1215-1217. doi:10.1002/ptr.3390
18. Jansakul C, et al. Eur J Pharmacol. 2012;691(1-3):235-244. doi:10.1016/j.ejphar.2012.07.019

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.