Vitamin B6 | Pyridoxal-5-Phosphate | Pyridoxal Phosphate | P-5-P | P5P | PLP
Pyridoxal 5'-phosphate (P5P) is the active form of (vitamin B6), which is part of the B complex—a group of water-soluble vitamins that play important roles in cellular metabolism and energy production. The term vitamin B6 refers to six forms—pyridoxal, pyridoxamine, pyridoxine, and their phosphorylated forms. The P5P form is the bioactive form of vitamin B6: it requires less metabolic “work” to be used as coenzyme in vitamin B6-dependent enzyme reactions. The more common form of vitamin B6 used in dietary supplements, pyridoxine, must undergo metabolic transformation and requires ATP to be converted into P5P. P5P is a cofactor involved in over 4% of all enzymatic activities, including many metabolic pathways important for cellular energy generation.  Major functions of P5P include (1) metabolism of fats, sugars, and proteins, (2) neurotransmitter synthesis, (3) synthesis of the hemoglobin used in red blood cells, and (4) increasing and decreasing the expression of certain genes.
Pyridoxal 5'-phosphate (P5P) is our preferred form of vitamin B6, because it’s the active (i.e, coenzyme) form of the vitamin. The pyridoxine form requires ATP to be “activated.” In general, we think it’s a good idea to conserve ATP for more important uses in our cells and tissues.
Pyridoxal 5'-phosphate sourcing is focused on identifying and purchasing from a reputable supplier and ensuring it’s NON-GMO, gluten-free and vegan.
Vitamin B6, no matter the form, is subject to a dosing threshold (see Neurohacker Dosing Principles), which means, while more might be better within a low to moderate range, very high amounts would be unlikely to add significant additional nutritional or functional benefits for most people but could increase the risk of unwanted responses. Our goal in formulating products is to make sure that vitamin B6 amounts will be comfortably below the levels where risk for unwanted responses exists, even if several of our products with vitamin B6 are used together. In general, we tend to dose vitamin B6 at higher amounts in formulations where it would be used to support neurotransmitter production, and lower levels when we are using it to compliment a full B complex stack. The main role of vitamin B6 in the body is as a coenzyme for metabolic reactions. It is important to have sufficient amounts of vitamin B6 in the diet to allow proper functioning of these enzymes.
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