Gotukola | Indian Pennywort | Asiatic Pennywort
Supports a calm mood and feelings of contentment*
Supports mental alertness and attention*
Supports a healthy stress response*
In Ayurvedic medicine, gotu kola (Centella asiatica; synonym is Hydrocotyle asiatica) is considered to be a mental rejuvenator (medhya Rasayana), where it was traditionally used as a tonic herb to counter mental fatigue and improve thinking. It was thought to be particularly useful during times of increased mental demands. Other traditional uses included support of blood/circulation, skin regeneration, and general longevity. Modern science has upheld some of this reputation—gotu kola is a nootropic and supports brain repair and rejuvenation processes. It also supports healthy veins and circulation. Gotu kola, unlike many other nootropics that are best taken only at the beginning of the day, is a great fit at the end of a busy day because it is calming and supports repair and rejuvenation processes. Gotu kola contains several characteristic bioactive compounds, including asiaticoside, asiatic acid, madecassic acid, madecassoside, and centelloside. Gotu kola also contains other compounds with biological activity found in other plants such as ursolic acid, rosmarinic acid, and the flavonoids apigenin and rutin.
Gotu kola is a whole herb extract. It is standardized to contain not less than 10% asiaticosides, since this group of active compounds are thought to be the main bioactives.
Gotu kola is Non-GMO and Vegan.
Because gotu kola is an Ayurvedic Rasayana herb, we consider dosing to follow hormetic principles similar to herbal adaptogens (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. Based on human studies, where extracts standardized for one or more of gotu kola’s asiaticosides have been used, we consider the target range of asiaticosides to be between about 12.5mg to 50mg for nootropic and mood purposes. The mg amount of gotu kola used will depend on its standardization and will be chosen to deliver an amount of asiaticosides within this range. Our goal with gotu kola, as with all ingredient choices, is to select the appropriate dose keeping in mind both the ingredient and the other ingredients being used in a formulation. In other words, if we are also supplying other adaptogens and nootropic extracts, we are likely to use less gotu kola than if the only herbal adaptogen/nootropic we were using was gotu kola.
Mood and stress response
Supports a calm mood[2–8]
Supports healthy behavioral and physiological responses to stress
Supports working memory
Supports learning and memory[9–15]
Supports executive function[10,11]
Supports glutamate decarboxylase (GAD) activity
Supports GABAergic neurotransmission
Supports GABA receptor agonist actions [asiatic acid][18–20]
Supports glutamatergic AMPA receptors 
Down-regulates acetylcholinesterase (AChE)[14,18]
Supports hippocampal synaptic density
Supports the expression of synaptic markers in the hippocampus and frontal cortex
Supports brain mitochondrial function[10,11,14,21,22]
Supports brain-derived neurotrophic factor (BDNF)[12,13,23,24]
Supports NMDA receptors
Supports hippocampal long-term potentiation
Supports Nrf2 signaling in the brain[10,11,21,22]
Supports antioxidant defenses[7,10,11,14,21,22,25]
Supports neuroprotective functions
Supports innate immunity
Supports adaptive immunity[28,29]
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