Magnesium (from Aquamin® Mg)

Magnesium is one of the most abundant minerals in the body and is vital for the functioning of all living cells. It’s used in more than 300 enzymes. ATP (i.e., cellular energy) occurs complexed with magnesium, so all enzymes utilizing ATP require magnesium. The same is true for enzymes that synthesize DNA and RNA, magnesium is always involved. Magnesium also plays a large role in breaking down sugars (glycolysis). Because magnesium supports the electrical functions of cells (i.e., it’s an electrolyte), muscle and nerve function rely on magnesium. Magnesium has a number of functional roles that interact with stress [1]. Aquamin^® Mg is a bioavailable source of magnesium that also contains lesser amounts of 71 other minerals (most of which are trace minerals) [2]. Aquamin^® Mg has been studied for supporting gut microbiota [3].* 

TOP BENEFITS OF MAGNESIUM

Supports sleep*

Supports mood*

Supports musculoskeletal health*

Supports cellular health*

NEUROHACKER’S MAGNESIUM SOURCING

Aquamin^® Mg is a natural source of magnesium derived from the clean sea waters off the Irish coast.

Magnesium from Aquamin^® is standardized to contain not less than 33% magnesium (as magnesium hydroxide). It also supplies 72 minerals and trace minerals.

Magnesium from Aquamin^® is a non-GMO, Vegan, Kosher certified, Halal certified, EU health certified, and Allergen free ingredient. 

Aquamin^® is a registered trademark of Marigot Ltd. of Cork Ireland.

MAGNESIUM FORMULATING PRINCIPLES AND RATIONALE

The Recommended Dietary Allowances for magnesium in adults varies from 310 to 420 depending upon age and gender. A majority of Americans of all ages fall somewhat short of this amount. Supplying even a low dose of magnesium can help close the gap. We generally supply it in small amounts to augment dietary intake of magnesium and complement other ingredients in a formula.*

MAGNESIUM KEY MECHANISMS

Supports metabolism and energy generation*

Required for the synthesis of ATP by ATP synthase in mitochondria* [4,5]

Forms a complex with ATP (MgATP) that is required for many rate-limiting metabolic enzymes* [6]

Cofactor for rate-limiting enzymes involved in carbohydrate and lipid metabolism* [6,7]

Cofactor for rate-limiting enzymes involved protein and nucleic acid synthesis* [6,7]

Supports cell signaling*

Supports cellular sodium and potassium influx and efflux* [6]

Modulates calcium entry into cells so supports balanced calcium signaling* [6,7]

Cofactor for protein phosphorylation (enzyme activation)* [6,7]

Cofactor for the activity of adenylate cyclase - cyclic adenosine monophosphate (cAMP) synthesis* [8]

Supports cell structure*

Stabilizes proteins, nucleic acids, chromosomes, and biological membranes* [6]

Supports healthy cardiovascular function*

Supports cardiac muscle contraction and heart rhythm* [7,9]

Supports vascular tone* [7,9]

Supports platelet function* [7,10]

Supports brain function*

Supports normal hearing* [11–17]

Supports normal neurotransmitter release and healthy neurological function* [7]

Supports the activity of the glutamate N-methyl-D-aspartate (NMDA) receptor* [18,19]

Supports glutamate dehydrogenase (GDH) enzyme - converts glutamate to α-ketoglutarate, and vice versa* [20,21]

Supports serotonin N-acetyltransferase - an enzyme that is involved in the day/night rhythmic production of melatonin from serotonin* [22,23]

Supports brain-derived neurotrophic factor (BDNF)* [19,24,25]

Supports a healthy mood*

Supports mental well-being* [26,27] 

Supports healthy behavioral and physiological responses to stress* [25,28–31] 

Supports sleep* 

Supports sleep quality* [32–39]

Supports healthy EEG and neuroendocrine responses during sleep* [40,41]

Supports exercise tolerance if sleep is insufficient* [42]

Supports musculoskeletal health*

Required for muscle contraction* [7,43]

Supports muscle strength* [44,45]

Supports bone metabolism/remodeling by calcium absorption* [6]

Supports calcitonin and parathyroid hormone activity* [6]

Supports bone formation* [6]

Supports a healthy gut microbiota*

Supports a healthy composition of the gut microbiota* [3,46,47]

Complementary ingredients*

Commonly supplemented with calcium for bone support* 

Supports vitamin D metabolism* [48]

B-complex vitamins and melatonin supplementation for sleep support* [49]

Zinc and melatonin supplementation for sleep support* [50]

Vitamin B6 for mood support* [51,52]

Hawthorn and California poppy for mood support* [53]

Antioxidant vitamins for hearing support* [54–56]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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