Gamma-Oryzanol

COMMON NAME

γ-Oryzanol | Ferulic Acids


TOP BENEFITS OF GAMMA-ORYZANOL

Supports antioxidant defenses*
Supports menopause*
Supports mood*
Supports nervous system*
Supports cognitive function*


WHAT IS GAMMA-ORYZANOL?

Gamma-oryzanol (γ-oryzanol) is a mixture of lipid molecules called steryl ferulates. Like many secondary metabolites in plants, and similar to tocopherols which also naturally occur in the oils of seeds, γ-oryzanol is considered to be an antioxidant. The best food source is rice bran and germ—γ-oryzanol gets its name from the botanical name for rice, Oryza sativa. γ-oryzanol has been sold in Japan since 1962, and most of the human studies on it have been done in Japan and published in non-English papers. These studies have focused primarily on supporting aspects of menopause, mood, nervous system, and heart health. Animal studies have suggested cognitive, mood, stress, immune and sleep support functions.*


NEUROHACKER’S GAMMA-ORYZANOL SOURCING

γ-Oryzanol is sourced from rice bran oil which goes through several extraction steps resulting in a finished product that contains not less than 97% γ-Oryzanol.

γ-Oryzanol is Non-GMO and Vegan.


GAMMA-ORYZANOL DOSING PRINCIPLES AND RATIONALE

One of our dosing principles is to determine whether there is a dosing range, in which many of the benefits occur and above which there appears to be diminishing returns (i.e., a threshold), and to provide a dose within this threshold range (see Neurohacker Dosing Principles ). We consider γ-oryzanol to be one of these threshold compounds. Very modest amounts of γ-oryzanol—10 to 50 mg a day—have been needed to produce a functional benefit in some of the human studies, so we will typically use a dose within this range. In parts of the world where rice bran oil is used or rice bran is consumed, it is a naturally occurring part of the diet; however, there would be a negligible amount found in a typical western diet. The modest dose of γ-oryzanol supplied can be thought of as augmenting the intake of an ingredient that’s not found in a meaningful amount in many people’s diets.*


GAMMA-ORYZANOL KEY MECHANISMS

Supports brain function*

Supports learning and memory [1–4]

Supports histaminergic neurotransmission [5,6]

Supports brain mitochondrial function [3,7,8]

Supports adrenergic signaling [9–11]

Supports serotonin signaling [9–11]

Supports synaptic plasticity [1]

Supports brain mitochondrial function and energy metabolism [1]

Supports neuronal antioxidant defenses [1,10,12–14]

Supports neuroprotection functions [13,15–17]

Supports healthy behavioral and physiological responses to stress [3,9,14,18–22]

Supports non-rapid eye movement (NREM) sleep [5,6]


Supports antioxidant defenses*

Supports antioxidant enzymes [1,14,17,23–25]  

Supports Nrf2 signaling [24]

Supports phase II antioxidant enzymes (HO-1, NQO1) [2,21,24]

Counters ROS production and oxidative stress [14,17]


Supports healthy aging and longevity*

Supports healthy cardiovascular function [23,26,27]

Supports healthy kidney function [28–30]

Supports healthy metabolic function [30–33]

Supports muscle strength [34]

Supports immune performance [35]

Supports mitochondrial function and biogenesis [3,7,17]

Supports autophagy [15,36]


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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