Biotin

Biotin Common Name

Vitamin B7 | Vitamin H

Top Benefits of Biotin

  • Supports cellular metabolic pathways*
  • Supports gene expression* 

What is Biotin?

Biotin, or vitamin B7, is part of the B complex—a group of water-soluble vitamins that play important roles in cellular metabolism and energy production. Biotin was originally called vitamin H, with “H” standing in for Haar und Haut, German words for hair and skin. This is because deficiency symptoms that led to the eventual discovery of biotin included skin inflammation and hair loss. Diet, lifestyle and genetic factors influence absorption of biotin in the diet and the ability of the gut microflora to make biotin, so some subsets of the population have more difficulty maintaining optimal biotin status than others. Biotin is an important in some enzymes involved in metabolizing fats and carbohydrates, influencing cell growth, and affecting amino acids involved in protein synthesis.

Neurohacker’s Biotin Sourcing

Biotin sourcing is focused on identifying and purchasing from a reputable supplier and ensuring it’s NON-GMO, gluten-free and vegan. 

Biotin Dosing Principles and Rationale

While the Institute of Medicine (IOM) hasn’t placed an upper limit on biotin, the advised intake (daily value [DV] on a supplement) is very low. We dose biotin in amounts consistent with the adult DV when we are using biotin to compliment a full B complex stack. Except for subsets of the population with rare genetic disorders that affect biotin metabolism, persons eating raw egg whites, and other rare situations, this low amount of biotin is sufficient to compliment a B complex stack. 

Biotin Key Mechanisms

  • Biotin is required for the activity of acetyl-CoA carboxylase 1 (ACC1) and ACC2, pyruvate carboxylase, methylcrotonyl-CoA carboxylase, and propionyl-CoA carboxylase (1–3)
  • Biotin-dependent enzymes have important roles in pathways associated with gluconeogenesis, lipid catabolism, and branched chain amino acid catabolism (1–3)
  • Biotin regulates chromatin structure and gene expression (1, 2)

REFERENCES

1. L. Riveron-Negrete, C. Fernandez-Mejia, Mini Rev. Med. Chem. 17, 529–540 (2017).
2. D. M. Mock, J. Nutr. 147, 1487–1492 (2017).
3. L. Tong, Cell. Mol. Life Sci. 70, 863–891 (2013).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.