In this article, we will take a look at how mitochondrial dysfunction can cause damage to cells and mitochondrial quality control pathways act to prevent or overcome that damage. We will also discuss how aging affects mitochondrial function and nutritional strategies to support it.
The gut microbiota influences many aspects of human physiology, from metabolism, to the cardiovascular system or the nervous system, for example. In this article, we focus on the interaction between the gut microbiota and our immune system.
Even with our staggering growth in technology and science, there’s a good chance we won’t make it to the year 2100. Change isn’t happening fast enough. The fate of humanity can no longer be left to politics or policy. Growth needs to start on a personal scale. We need, at a fundamental level, to become better humans.
Join us as we explore interval workouts for longevity, how aromatherapy impacts food cravings, the link between mitochondrial fitness and mental health, and why your brain is begging for a little downtime in this edition of Neurohacking Advancements.
In this article, we’re going to introduce an indirect way of supporting NAD+. Rather than making more, this article will be teaching you about using less. Using less requires downregulating a protein called cluster of differentiation 38 (CD38 for short). When CD38 is not as active, less NAD+ is used by it. The result is higher NAD+ levels and greater NAD+ availability for important healthy aging uses.
In honor of Stress Awareness month we bring you twelve simple, yet effective, ways to get our bodies, minds, and souls back on track, especially when we are under high stress.
Supercharge your cells for better aging each morning with this nutrient-packed smoothie. This berry smoothie recipe is packed with antioxidants, protein, collagen, and Eternus to deliver focus, energy, and mitochondrial support. It's the perfect concoction to jumpstart your day!
Key Learning Objectives
In September-October 2018, a 3-week sample of Eternus was sent to volunteers. Volunteers were selected to include a mix of people who were and were not currently taking Qualia. No information was given on what product was intended to do, ingredients contained in the product, or expected responses. Instructions were to take 8 capsules with breakfast 5 days a week, with 2 off days, for 3 weeks. All participants were asked to complete a survey questionnaire after 5 days, 2 weeks, and 3 weeks. Seventy-one persons completed the 3 weeks of supplementation and provided responses to the survey.
We all age. But, we don’t all age at the same rate. From a bottom-up point of view, we are a complex colony of tens of trillions of individual cells. We care about what healthier cells allows the body to do better. Eternus is our solution to cell support for better aging.
Gynostemma pentaphyllum (Southern Ginseng) is an herb attributed with having ginseng status. Until fairly recently Gynostemma pentaphyllum was used primarily in mountainous regions of southern China and northern Vietnam. It’s been described as the "immortality herb,” because people within Guizhou Province, where herbal teas made from the plant are consumed regularly, are said to have a history of unusual longevity.
ElevATP® is a proprietary, clinically researched combination of a water extract of “ancient peat” (fossilized plants) and apple extract. The ancient peat contains 70 elements and is especially rich in carbon, magnesium, nitrogen, oxygen, and sulfur. ElevATP® is a clinically tested product with human studies for sports performance, body composition, and elevating ATP.
Strawberries are a good source of polyphenols. The seeds are an even better source. We made sure to source an extract standardized for at least 2% polyphenols. Studies of this extract suggest it might support healthy skin, weight, metabolism, and other functions needed for healthy aging.* Strawberry polyphenols would also be expected to support antioxidant defenses and overall cellular health.* But the main reason we included the strawberry seed extract is because it is a source of a specific flavonoid called tiliroside.
Citrus × sinensis is the group of oranges that includes the commonly eaten navel orange and the blood orange. The peels and fruit are a rich source of citrus bioflavonoids. But our interest went beyond just including a generic citrus bioflavonoid mixture. What we were really interested in is a specific polymethoxylated flavone called nobiletin. Nobiletin has been identified as clock-enhancing small molecule, so is a key nutrient to support body clock functions.
Rutin is a type of polyphenol called a flavonoid glycoside. It’s composed of quercetin and the disaccharide rutinose. It’s also called rutoside, quercetin-3-O-rutinoside and sophorin. While it’s found in a wide variety of plants, including citrus, foods with the highest concentrations of rutin include capers, black olives, buckwheat, and asparagus. The most common use of rutin has been for supporting healthy veins. But it does much more.
Apigenin belongs to the flavone class of polyphenol compounds. It is one of the more common flavones in the diet, found in many fruits and vegetables, including celery and parsley. It’s also found in high amounts in the flowers used to make chamomile tea.
β-Hydroxy-β-Methylbutyrate (HMB) is a metabolite of l-leucine (an essential amino acid). As we get older, muscle size, strength, and performance decline. This can occur even if we continue to exercise. HMB has been used as an ergogenic substance (i.e., something that supports improved sports performance) for more than 20 years, with most of the research focused on supporting muscle performance and helping muscles age better.
Rosemary is a member of the mint family. Its common name derives from Latin and translates as “dew of the sea,” because it thrives close to the coast in dryer areas throughout the Mediterranean. It was used as a spice and folk medicine by Egyptians, Greeks, and Latin cultures. While rosemary contains a range of health-supporting polyphenols, including carnosol, carnosic acid, and rosmarinic acid, our main interest was in a triterpene in rosemary called ursolic acid, which supports muscle performance.
Kaempferia parviflora is found in the upper northeastern regions of Thailand. It is commonly called black ginger, because of the intense purple-black color and similar shape of the roots to ginger. The traditional use has been as a health tonic and energy enhancer leading to it sometimes being called “Thai ginseng.” The novel active constituents are polymethoxyflavonoids polyphenols.
In 1958, Jack Preiss and Philip Handler published a scientific paper describing how NAD+ was made from niacin in three steps.(1) This pathway was later named the Preiss-Handler pathway after the co-discoverers. It describes the enzyme steps needed to convert niacin into the NAD+ molecule.
Theobroma cacao can be translated as chocolate, food of the gods. This tree is native to the tropical regions of the Americas. The beans are the source of the cocoa used to make chocolate. But this extract is more than simply a pleasure for our tastebuds. Over the past decade chocolate has had a blossoming reputation as being heart healthy. As it turns out, it might also be good for our mitochondrial structure and function.
Vitamin K is a family of structurally similar, fat-soluble vitamins. The two main members of the family are vitamin K1 and K2. Our interest in vitamin K was prompted when looking for compounds that might be able to rescue mitochondrial performance. This led us to source vitamin K2, ultimately as MK-7.
The main role of vitamin B3 is to make NAD molecules. This is important because the NAD molecule sits at the crossroads of mitochondrial energy production (i.e., ATP), cellular repair and signaling, and cellular defenses. Unfortunately, NAD+ levels decrease with age. This is the bad news. The good news is that there are strategies that can be used to make more NAD+. One of these is vitamin B3.
L-tryptophan is an essential amino acid. This means the body cannot synthesize it: it must be obtained from the diet. It’s been known for decades that L-tryptophan has niacin equivalent activity in the body (i.e., we can make NAD+ molecules from it). L-tryptophan is unique because it’s the only way to build NAD+ that doesn’t start from vitamin B3. It does this by a de novo synthesis pathway, which creates a niacin molecule through a series of biological reactions. So, L-tryptophan’s inclusion would seem to be a natural fit in a formulation that wants to support boosting NAD+.
BioVin® is a premium quality grape extract made from the juice, seeds, and skins of red grapes grown in France. It's rich in both trans-resveratrol and grape polyphenols.
