Celastrus Paniculatus Seed Extract

CELASTRUS PANICULATUS COMMON NAME

Celastrus | Intellect Tree | Jyotishmati

TOP BENEFITS OF CELASTRUS PANICULATUS

Supports cognitive performance*

Supports mood*

Supports stress response*

WHAT IS CELASTRUS PANICULATUS?

Celastrus paniculatus is native to India, where it’s used by local healers primarily as a brain tonic for reasons that are consistent with one of its common names, “the intellect tree.” Today we’d recognize these uses as offering nootropic support. These uses include “...mental acuity, support memory and intellect as well as retention and recalling power; and to alleviate mental fatigue, stress...”*[1] It was believed that people using this plant would be able to learn new information more quickly, and more accurately and efficiently recall it later.*[1] Celastrus paniculatus seeds (and their oil) are what is used for cognitive support. The seeds contains a variety of active compounds, including sesquiterpenes such as celastrine, celapanine, celapanigine, celapagin, malkangunin and paniculatine. Celastrus paniculatus extracts have, in experimental research, positively influenced cognitive function and neuroprotective functions.*

NEUROHACKER’S CELASTRUS PANICULATUS SOURCING

Celastrus paniculatus is an alcohol extract of the seeds.

Grown in India.

Celastrus paniculatus is non-GMO, gluten-free, vegan, 

CELASTRUS PANICULATUS DOSING PRINCIPLES AND RATIONALE

One way Celastrus paniculatus was traditionally used was to have a person start by eating one seed a day in the diet, and then gradually increase by one seed a day, up to a maximum of 100 seeds daily.[1] This suggests to Neurohacker that the best way to approach dosing would be to consider Celastrus paniculatus as an adaptogenic herb; following hormetic dosing principles (see Neurohacker Dosing Principles) with a high likelihood of having a hormetic range (i.e., a dosing range below and above which results could be poorer). We have selected to dose this at a low-to-moderate amount because of both the traditional approach to use, and because of our N of 1 dosing experience in product development and testing.*

CELASTRUS PANICULATUS KEY MECHANISMS 

Brain function and structure

Supports memory and facilitates learning [2,5,7]

Reverses experimentally-induced memory and learning impairments in animals [5,8–11]

Supports the levels of monoamine neurotransmitters (noradrenaline, dopamine and serotonin) and their metabolites in the brain [2]

Interacts with dopamine-D2, serotonergic, GABAB, and NMDA receptors [3,4]

Downregulates brain MAO-A levels [3]

Downregulates acetylcholinesterase activity in the brain [5]

Supports brain content of total lipids and phospholipids [6]

Supports neuroprotective functions [4,11,13,14]

Mood and Stress

Supports mood [3,8,12]

Downregulates plasma corticosterone (stress hormone) levels [3]

Antioxidant defenses

Supports brain antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) [7,11,13–17]

Replenishes glutathione (GSH) levels [7,11,15]

Downregulates lipid peroxidation [7,11,13–17]

Supports Free-radical-scavenging activity [14,16,18]

Other effects

Modulates cellular signaling [17,19,20]

Supports relief of minor physical discomfort [19,20]

Gastroprotective effect [17]

Supports healthy cholesterol levels [21]


REFERENCES

[1] N. Arora, S.P. Rai, Int. J. Pharma Bio Sci. 3 (2012) 290–303.
[2] K. Nalini, K.S. Karanth, A. Rao, A.R. Aroor, J. Ethnopharmacol. 47 (1995) 101–108.
[3] R. Valecha, D. Dhingra, Basic Clin Neurosci 7 (2016) 49–56.
[4] P.B. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, J. Ethnopharmacol. 93 (2004) 213–219.
[5] M. Bhanumathy, M.S. Harish, H.N. Shivaprasad, G. Sushma, Pharm. Biol. 48 (2010) 324–327.
[6] P.P. Bidwai, D. Wangoo, N.K. Bhullar, J. Ethnopharmacol. 21 (1987) 307–314.
[7] M.H.V. Kumar, Y.K. Gupta, Phytomedicine 9 (2002) 302–311.
[8] V. Bhagya, T. Christofer, B.S. Shankaranarayana Rao, Indian J. Pharmacol. 48 (2016) 687–693.
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[11] J. Malik, M. Karan, R. Dogra, Pharm. Biol. 55 (2017) 980–990.
[12] R. Rajkumar, E.P. Kumar, S. Sudha, B. Suresh, Fitoterapia 78 (2007) 120–124.
[13] M. Chakrabarty, P. Bhat, S. Kumari, A. D’Souza, K.L. Bairy, A. Chaturvedi, A. Natarajan, M.K.G. Rao, S. Kamath, J. Pharmacol. Pharmacother. 3 (2012) 161–171.
[14] P.B. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, Phytomedicine 13 (2006) 29–36.
[15] G. Lekha, K. Mohan, I.A. Samy, Pharmacognosy Res. 2 (2010) 169–174.
[16] P. Godkar, R.K. Gordon, A. Ravindran, B.P. Doctor, Fitoterapia 74 (2003) 658–669.
[17] S. Palle, A. Kanakalatha, C.N. Kavitha, J. Diet. Suppl. 15 (2018) 373–385.
[18] A. Russo, A.A. Izzo, V. Cardile, F. Borrelli, A. Vanella, Phytomedicine 8 (2001) 125–132.
[19] F. Ahmad, R.A. Khan, S. Rasheed, J. Ethnopharmacol. 42 (1994) 193–198.
[20] Y.A. Kulkarni, S. Agarwal, M.S. Garud, J. Ayurveda Integr. Med. 6 (2015) 82–88.
[21] R.H. Patil, K. Prakash, V.L. Maheshwari, Indian J. Clin. Biochem. 25 (2010) 405–410.