Cognizin Citicoline

COMMON NAME

Citicoline | CDP-choline | Cytidine 5'-diphosphocholine 

TOP BENEFITS OF CITICOLINE

  • Supports mental energy *
  • Supports focus and attention *
  • Supports brain health and cognitive performance *

WHAT IS CITICOLINE?

Citicoline is a choline and cytidine-containing intermediate in the generation of phosphatidylcholine from choline. It can be used to augment the body and brain choline pool. Citicoline and Alpha-glycerophosphocholine (alpha-GPC) are considered the nootropic forms of choline, with both being able to increase brain choline levels, act as building blocks for acetylcholine, and support choline-dependent functions. Following ingestion, citicoline yields choline and cytidine [1,2], the latter being converted into uridine in humans [3]. These compounds can be used to produce the phosphatidylcholine needed for the structure and function of healthy cell membranes  [4,5]. Phosphatidylcholine can also be used for acetylcholine synthesis [6,7]. Acetylcholine is central to brain neurotransmission; it plays a supportive role in attention, concentration, mental focus, and memory. Acetylcholine is also used in both the fight or flight and rest and relax parts of the autonomic nervous system, and it is a signaling molecule for activating muscles. Cognizin® is a branded citicoline (CDP-choline) that provides nutritional support for brain energy, attention, focus, and recall.

NEUROHACKER’S CITICOLINE SOURCING

Cognizin® is a patented and clinically studied form of citicoline, a substance vital to brain health and energy.

Cognizin® Citicoline has been used in a number of human studies. It provides nutritional support for brain energy, attention, focus, and recall.

Cognizin® Citicoline is non-GMO, vegan, Kosher, and GRAS.

Cognizin® is a registered trademark of Kyowa Hakko Bio Co.

CITICOLINE DOSING PRINCIPLES AND RATIONALE

Cognizin® Citicoline is typically dosed in amounts between 250 and 500 mg/day when used alone as a nootropic in healthy adults. Neurohacker believes the evidence suggests a threshold response (see Neurohacker Dosing Principles) for citicoline when given to healthy people, which means the majority of functional benefits occur at the lower end of the range, with a doubling of the dose from 250 to 500 mg producing only modest additional functional gains. The amount included in a formulation may be below the amount used in studies when it has been given alone, because Neurohacker Collective’s experience with citicoline is that, when used with other ingredients that influence choline levels and metabolism, a more modest dose can be sufficient.  

CITICOLINE KEY MECHANISMS

Choline donor

  • Citicoline is part of the Kennedy (or CDP-choline) pathway, which has a central role in choline homeostasis [8–10]
  • Supports plasma levels of choline [11]
  • Supports plasma levels of uridine [11]
  • Precursor for phosphatidylcholine synthesis [4,5,7]
  • Precursor for acetylcholine synthesis [6,7]

Brain and cognitive function

  • Supports memory and learning [12–18]
  • Supports working memory [18]
  • Supports attention [19,20]
  • Supports processing speed [18]
  • Supports executive function [18]
  • Supports cognitive health [12,16,17,21]
  • Supports brain energetics and ATP [22]
  • Supports acetylcholine synthesis and release [6,7,21]
  • Supports cholinergic neurotransmission [23,24]
  • Supports brain phospholipid synthesis [7,22,25–27]
  • Supports brain mitochondrial phospholipid and protein production [28,29]
  • Supports dopamine release [30,31]
  • Supports dopaminergic neurotransmission [24,32]
  • Supports brain (frontal lobe) bioenergetics [22]
  • Supports brain bioelectrical activity [12]
  • Supports cerebral blood flow [12]
  • Supports brain plasticity [33]
  • Supports neuroprotective functions [21,26,27,33–40]
  • Supports neuronal cell membrane stabilization [26,36]
  • Supports brain glutathione levels [27]
  • Supports brain SIRT1 levels [38]

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