LactoSpore® Bacillus coagulans

LactoSpore^® is a patented, clinically studied spore-forming probiotic (sometimes described as a sporebiotic). In research studies, it is called Bacillus coagulans, MTCC 5856 (in older studies it was called Lactobacillus sporogenes). Bacillus coagulans was first isolated and described in 1933. It is an L(+) lactic acid-producing spore-forming bacterium that lives in the soil (i.e., a soil-based organism or SBO). Spore-forming probiotics, like Bacillus coagulans, can be thought of as being akin to seeds from plants that germinate and grow when placed in the right conditions. The naturally protected spore form allows Bacillus coagulans to be (1) stable at room temperature (i.e., it does not require refrigeration), (2) remain dormant to survive the harsh conditions of the stomach, and (3) germinate and proliferate when it reaches the intestine. The special MTCC 5856 strain—probiotic strains can sometimes have unique functional actions that other members of their genus and species do not share—was developed by Sabinsa and has been sold since 1991.

TOP BENEFITS OF LactoSpore^®

Supports digestive health* 

Supports healthy gut microbiota*

Supports gut-brain health*

NEUROHACKER’S LactoSpore^® SOURCING

LactoSpore^® is backed by strong science; it has been clinically-studied as a probiotic and a psychobiotic (i.e., a probiotic with gut-brain actions).* 

LactoSpore^® strain purity, consistency, and authenticity are established through genotyping and phenotypic characterization.

LactoSpore^® has a minimum activity of 15 billion spores per gram.

LactoSpore^® is a non-GMO Project Verified, gluten-free, vegan, and certified Halal and Kosher ingredient.

LactoSpore^® is a registered trademark of Sabinsa Corporation, USA.

LactoSpore^® FORMULATING PRINCIPLES AND RATIONALE

We chose Lactospore^® for a couple reasons. Most probiotics are fragile. They require refrigeration and do poorly when exposed to air and moisture (which they are repeatedly exposed to when containers are opened and closed). We wanted a resilient probiotic.   Lactospore^® is resilient: it is shelf-stable and doesn’t require refrigeration. Probiotics are “live microorganisms which when administered in adequate amounts confer a health benefit on the host” [1]. The most well-supported benefits they confer are with digestive health—probiotics work in the gut. But some probiotics also support the brain end of the gut-brain axis. These are called “psychobiotics.” We selected Lactospore^® because it is a probiotic that’s also a psychobiotic [2].* We selected our suggested serving to match the clinically studied dose of 2 billion CFU [2–4] [Note: CFU stands for colony-forming units: it is the number of live cells in a serving.]

Bacillus coagulans KEY MECHANISMS 

Supports gastrointestinal health and gut microbiota* 

Supports healthy gastrointestinal function* [2–5]

Supports mucosal barrier integrity and gut barrier functions* [6,7]

Supports general health and well-being*

Supports positive mood* [2]

Helps oppose oxidative stress* [7]

Supports healthy immune function* [8,9]

Complementary ingredients*

Bacillus subtilis in supporting digestion, gastrointestinal function, gut barrier function, and healthy gut microbiota composition* [10,11]

Bacillus subtilis + Bacillus clausii in supporting digestion* [12]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES

[1]C. Hill, F. Guarner, G. Reid, G.R. Gibson, D.J. Merenstein, B. Pot, L. Morelli, R.B. Canani, H.J. Flint, S. Salminen, P.C. Calder, M.E. Sanders, Nat. Rev. Gastroenterol. Hepatol. 11 (2014) 506–514.

[2]M. Majeed, K. Nagabhushanam, S. Arumugam, S. Majeed, F. Ali, Food & Nutrition Research 62 (2018).

[3]M. Majeed, K. Nagabhushanam, S. Natarajan, A. Sivakumar, F. Ali, A. Pande, S. Majeed, S.K. Karri, Nutr. J. 15 (2016) 21.

[4]M. Majeed, K. Nagabhushanam, S. Paulose, S. Arumugam, L. Mundkur, Medicine 102 (2023) e33109.

[5]L. Hun, Postgrad. Med. 121 (2009) 119–124.

[6]S.-C. Xing, C.-B. Huang, J.-D. Mi, Y.-B. Wu, X.-D. Liao, Environ. Pollut. 255 (2019) 113139.

[7]T. Wu, Y. Zhang, Y. Lv, P. Li, D. Yi, L. Wang, D. Zhao, H. Chen, J. Gong, Y. Hou, Int. J. Mol. Sci. 19 (2018).

[8]S.B. Ghavami, A. Yadegar, H.A. Aghdaei, D. Sorrentino, M. Farmani, A.S. Mir, M. Azimirad, H. Balaii, S. Shahrokh, M.R. Zali, Int. J. Mol. Sci. 21 (2020).

[9]T.V. Bomko, T.N. Nosalskaya, T.V. Kabluchko, Y.V. Lisnyak, A.V. Martynov, J. Pharm. Pharmacol. 69 (2017) 1033–1040.

[10]L. Wauters, H. Slaets, K. De Paepe, M. Ceulemans, S. Wetzels, K. Geboers, J. Toth, W. Thys, R. Dybajlo, D. Walgraeve, E. Biessen, K. Verbeke, J. Tack, T. Van de Wiele, N. Hellings, T. Vanuytsel, Lancet Gastroenterol Hepatol 6 (2021) 784–792.

[11]M. Marzorati, P. Van den Abbeele, S.S. Bubeck, T. Bayne, K. Krishnan, A. Young, D. Mehta, A. DeSouza, Microorganisms 8 (2020).

[12]R.J. Soman, M.V. Swamy, International Journal of Colorectal Disease 34 (2019) 1971–1978.