Puremidine™ Spermidine (as spermidine trihydrochloride)




Supports healthy aging*

Supports healthy brain function*

Supports skin health*


Spermidine is a polyamine that was first discovered in 1678. It may be best known for supporting autophagy, which can be thought of as a cell's natural recycling program. In addition to autophagy, spermidine plays important roles in responding to stress (as part of the polyamine stress response (PSR), and supporting cellular growth, DNA stability, brain health, and tissue growth and repair. Spermidine is found in many foods, including wheat germs, nuts, soybeans, mushrooms, and fermented products. Polyamine-rich foods—foods containing higher amounts of spermidine and other polyamines—have been linked to healthier aging in a range of organisms [1].  


PuremidineTM is ≥98% Spermidine Trihydrochloride.

PuremidineTM is a non-GMO, gluten-free, vegan, and certified Halal and Kosher ingredient.

PuremidineTM is a trademark of NNB Nutrition. 


Spermidine can be obtained from the diet. It can also be made within the body. Despite these two ways of supplying it, the concentrations in some tissues (including the brain) of spermidine and other polyamines may decrease with increasing age [2,3]. Supplementing some additional spermidine, or eating more polyamine-rich foods, can act as a way to augment or refill polyamine pools that may decline during aging in various tissues. Higher intake of spermidine has been associated with healthier brain structure in older adults, as an example [4]. In human studies, spermidine has been supplied in amounts ranging from about ½ a mg to 3 mg [5–7]. The amount of PuremidineTM in a suggested serving of Qualia Life supplies 2 mg of spermidine; this is an amount within the studied range.


Supports healthy aging and longevity*

Supports polyamine levels* [8]

Supports autophagy and mitophagy* [8–13]

Supports mitochondrial function* [9,10,12,14]

Supports telomere length* [15]

Supports healthy brain function*

Supports cognitive function during aging* [8,11,12,16,17]

Supports synaptic function and structure during aging* [18]

Supports neuronal mitochondria during aging* [10,18,19]

Supports brain glucose metabolism* [15]

Supports neural autophagy* [9,10,20]

Supports brain antioxidant defenses and counters oxidative stress* [9]

Supports BDNF levels* [9]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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