Citrus sinensis L. Fruit Extract: Sources and Benefits

Citrus × sinensis is the group of oranges that includes the commonly eaten navel orange and the blood orange. The peels and fruit are a rich source of citrus bioflavonoids. Citrus bioflavonoids have been used to support healthy blood vessels and veins. 

Flavonoids tend to promote antioxidant defenses and a balanced inflammatory response.* Citrus flavonoids share these properties. Citrus bioflavonoids are synergistic with rutin—another important flavonoid in the cellular health and mitochondrial function stack. But our interest went beyond just including a generic citrus bioflavonoid mixture. What we were really interested in is a specific polymethoxylated flavone called nobiletin. 

Benefits of Nobiletin

Nobiletin positively influences AMPK, Nrf2 and NQO1 pathways, which play important roles in protecting cells and mitochondria, while upregulating NAD⁺ and ATP production. Nobiletin promotes better insulin signaling and it upregulates mitochondrial performance. It also supports the gut microbiome. These are important areas. But what makes nobiletin unique is clock support.*

Body clock function is rarely discussed when it comes to healthy aging, improving shape, and optimizing metabolic health. But healthy body clock function is as important as other pillars of a healthy lifestyle such as sleep, diet, and exercise. Disrupting body clock function, on its own, is sufficient to trigger weight gain, worsen metabolic health, and contribute to premature aging. And, aging is characterized by a gradual loss of body clock health.

Healthy body clock function is as important as other pillars of a healthy lifestyle such as sleep, diet, and exercise.

Optimizing body clock function is needed for long-term health and performance. This tends to be under-appreciated. This isn’t the case with Eternus. Supporting body clock function is a major emphasis.

Clock functions allow cells to work effectively, scheduling processes so they don’t interfere with each other, while allocating finite resources most efficiently. Clock functions enable internal processes to synchronize with the outside world, coordinating cellular processes and physiological functions in anticipation of behaviors like feeding and sleep-wake cycles.

Neurohacker’s Nobiletin Sourcing

Nobiletin has been identified as clock-enhancing small molecule,* so is a key nutrient in the body clock substack. We found a company which has been making citrus bioflavonoids since 1950 and chose their highest concentration nobiletin citrus extract in a blend of other citrus bioflavonoids. It costs more than the citrus bioflavonoids found in most dietary supplements. We think it’s worth it. 

* These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure or prevent any disease. The information on this site is for educational purposes only and should not be considered medical advice. Please speak with an appropriate healthcare professional when evaluating any wellness related therapy. Please read the full medical disclaimer before taking any of the products offered on this site.