Cranberry Fruit Extract

COMMON NAME

Cranberry | American Cranberry | Large Cranberry | Bearberry

TOP BENEFITS OF CRANBERRY FRUIT EXTRACT

  • Supports general immune health*
  • Supports urinary tract health*
  • Supports a healthy gut microbiota *

WHAT IS CRANBERRY FRUIT EXTRACT?

Cranberries are the fruits of several related species, including Vaccinium macrocarpon (American cranberry) and V. oxycoccos (European cranberry). More than 90% of the world's cranberries are grown in the Northeast United States and Canada, with most being made into juice and sauce, or sold as sweetened, dried cranberries. All cranberries belong to the genus Vaccinium, which also includes berries such as blueberries and huckleberries. Similar to these other berries, where much of the health benefits are attributed to the compounds that give color, the proanthocyanidins (often abbreviated as PACs) that contribute to the distinctive red color of cranberries are thought to be responsible for much of their health properties. Cranberry supplements are usually concentrated for these PACs, and are best known for supporting urinary tract health. Their role in urinary tract health is related to the immune system, specifically to a role in supporting important aspects of mucosal barrier functions (which is part of the innate immune system). Cranberries also enhance trained immunity—essentially supporting fitter immune cells—and cellular intrinsic immune defenses, making individual cells more resistant to external stressors.

NEUROHACKER’S CRANBERRY FRUIT EXTRACT SOURCING

Cranberry fruit extract is made from American cranberries (Vaccinium macrocarpon) grown in the United States. 

Cranberry fruit extract is concentrated and standardized to contain not less than 30% cranberry proanthocyanidins.

Cranberry fruit extract is Kosher, Halal, non-allergenic, non-GMO, gluten-free, and vegan.

CRANBERRY FRUIT EXTRACT DOSING PRINCIPLES AND RATIONALE

Cranberry fruit extracts are dosed based on their content of proanthocyanidins (PACs). Evidence suggests cranberry fruit extracts are dose-dependent with a threshold response (see Neurohacker Dosing Principles) where immune support benefits tend to occur in a range of between 36 and 72 mg per day of PACs. Neurohacker Collective doses cranberry fruit extracts to deliver a number of PACs within this range.

CRANBERRY FRUIT EXTRACT KEY MECHANISMS

Immunity

  • Supports general immune health[1]
  • Supports cellular intrinsic immune defenses[2–7]
  • Supports mucosal immunity[8–14]
  • Supports γδ-T cell function[1]

Gut microbiota

  • Supports a healthy gut microbiota[15–18]

Healthy aging

  • Supports antioxidant defenses[19,20]
  • Supports mitochondrial function[21,22]
  • Supports Nrf2[22,23]
  • Supports healthspan (worms)[24]

REFERENCES

[1] M.P. Nantz, C.A. Rowe, C. Muller, R. Creasy, J. Colee, C. Khoo, S.S. Percival, Nutr. J. 12 (2013) 161.
[2] S.M. Lipson, P. Cohen, J. Zhou, A. Burdowski, G. Stotzky, Mol. Nutr. Food Res. 51 (2007) 752–758.

[3] E. Oiknine-Djian, Y. Houri-Haddad, E.I. Weiss, I. Ofek, E. Greenbaum, K. Hartshorn, Z. Zakay-Rones, Planta Med. 78 (2012) 962–967.

[4] E.I. Weiss, Y. Houri-Haddad, E. Greenbaum, N. Hochman, I. Ofek, Z. Zakay-Rones, Antiviral Res. 66 (2005) 9–12.

[5] M.E. Terlizzi, A. Occhipinti, A. Luganini, M.E. Maffei, G. Gribaudo, Antiviral Res. 132 (2016) 154–164.

[6] A. Luganini, M.E. Terlizzi, G. Catucci, G. Gilardi, M.E. Maffei, G. Gribaudo, Front. Microbiol. 9 (2018) 1826.

[7] X. Su, A.B. Howell, D.H. D’Souza, Food Microbiol. 27 (2010) 535–540.

[8] A. Howell, D. Souza, M. Roller, E. Fromentin, Nat. Prod. Commun. 10 (2015) 1215–1218.

[9] I. Singh, L.K. Gautam, I.R. Kaur, Int. Urol. Nephrol. 48 (2016) 1379–1386.

[10] H. Liu, A.B. Howell, D.J. Zhang, C. Khoo, Food Funct. 10 (2019) 7645–7652.

[11] G. Tempera, S. Corsello, C. Genovese, F.E. Caruso, D. Nicolosi, Int. J. Immunopathol. Pharmacol. 23 (2010) 611–618.

[12] A. Occhipinti, A. Germano, M.E. Maffei, Urol. J. 13 (2016) 2640–2649.

[13] J.F. Pierre, A.F. Heneghan, R.P. Feliciano, D. Shanmuganayagam, C.G. Krueger, J.D. Reed, K.A. Kudsk, JPEN J. Parenter. Enteral Nutr. 38 (2014) 107–114.

[14] J.F. Pierre, A.F. Heneghan, R.P. Feliciano, D. Shanmuganayagam, D.A. Roenneburg, C.G. Krueger, J.D. Reed, K.A. Kudsk, JPEN J. Parenter. Enteral Nutr. 37 (2013) 401–409.

[15] N. Bekiares, C.G. Krueger, J.J. Meudt, D. Shanmuganayagam, J.D. Reed, OMICS 22 (2018) 145–153.

[16] K. O’Connor, M. Morrissette, P. Strandwitz, M. Ghiglieri, M. Caboni, H. Liu, C. Khoo, A. D’Onofrio, K. Lewis, PLoS One 14 (2019) e0224836.

[17] X. Cai, Y. Han, M. Gu, M. Song, X. Wu, Z. Li, F. Li, T. Goulette, H. Xiao, Food Funct. 10 (2019) 6331–6341.

[18] J. Rodríguez-Morató, N.R. Matthan, J. Liu, R. de la Torre, C.-Y.O. Chen, J. Nutr. Biochem. 62 (2018) 76–86.

[19] A. Skarpańska-Stejnborn, P. Basta, J. Trzeciak, A. Michalska, M.E. Kafkas, D. Woitas-Ślubowska, J. Int. Soc. Sports Nutr. 14 (2017) 7.

[20] T. Bariexca, J. Ezdebski, B.W. Redan, J. Vinson, Foods 8 (2019).

[21] E.A. Lapshina, M. Zamaraeva, V.T. Cheshchevik, E. Olchowik-Grabarek, S. Sekowski, I. Zukowska, N.G. Golovach, V.N. Burd, I.B. Zavodnik, Cell Biochem. Funct. 33 (2015) 202–210.

[22] M.-C. Denis, Y. Desjardins, A. Furtos, V. Marcil, S. Dudonné, A. Montoudis, C. Garofalo, E. Delvin, A. Marette, E. Levy, Clin. Sci. 128 (2015) 197–212.

[23] S.A. Faheem, N.M. Saeed, R.N. El-Naga, I.M. Ayoub, S.S. Azab, Front. Pharmacol. 11 (2020) 218.

[24] S. Guha, O. Natarajan, C.G. Murbach, J. Dinh, E.C. Wilson, M. Cao, S. Zou, Y. Dong, Nutrients 6 (2014) 911–921.