Artichoke Stem and Leaf Extract


Artichoke, Globe Artichoke, French Artichoke


  • Supports vascular health *
  • Supports metabolic health *
  • Supports antioxidant defenses *


Artichoke (Cynara scolymus) is a native plant of the Mediterranean (North Africa and southern Europe) with well-known nutritional and health benefits. Artichoke leaves (called “bracts”) are a rich source of bioactive polyphenolic compounds with antioxidant and cell protective effects—artichoke’s total antioxidant capacity is one of the highest reported for vegetables [1]. Compounds found in artichoke include phenolic acids (caffeic, quinic acid, cynarin, and chlorogenic acid), flavonoids (luteolin, cynaroside, and sculomoside), and anthocyanidins (cyanidin, peonidin, and delphinidin). Artichoke extract has a long history of use for heart, metabolic, gastrointestinal, and liver health, with many of its functional benefits supported by clinical trials [2]. While it has not been an area of research yet, artichoke has a reputation for supporting cognitive performance among neurohackers, especially in areas touching on mood, motivation, and memory.


Artichoke Leaf Extract is made from the dried leaf and standardized for 4% cynarin and related flavonoids to ensure that it would have an adequate phenolic content.

Artichoke Extract is non-GMO, gluten-free and vegan.


In clinical studies, the dose of artichoke leaf extract used has typically ranged from 500 to 1800 mg/day, with some of the difference in dose based on the standardization of the extract used. Our dose is consistent with this dose range. Neurohackers often combine artichoke leaf extract with other compounds—the combination of artichoke with Coleus forskohlii is a popular nootropic stack—so Neurohacker Collective believes, in addition to the standardization, a key consideration when considering the dose of artichoke is both the intended use and other ingredients it’s combined with. While artichoke is a food, because the extract we use is standardized for flavonoid molecules, and flavonoids tend to follow hormetic dosing principles (see Neurohacker Dosing Principles), we believe doses toward the middle to lower end of the dosing range, especially when combined with other flavonoid-containing ingredients, are sufficient to support healthy function.


Heart and vascular health

  • Supports healthy vascular function [3–7]
  • Supports endothelial cell function [5,7–10]
  • Supports endothelial nitric oxide synthase (eNOS) and NO production [5,7,8]
  • Supports healthy blood cholesterol levels [4,9,11–15]
  • Supports blood flow [9]
  • Supports antioxidant defenses [1,7,10,16]
  • Supports healthy LDL particles (may help counter LDL oxidation) [17]


  • Supports healthy blood glucose levels [14,18,19]
  • Supports healthy insulin signaling [20]

Other effects

  • May support flow through the cAMP>Creb>BDNF pathway by influencing phosphodiesterase (PDE4) [luteolin] [21]
  • Supports liver structure and function [3,15]


  • Artichoke Leaf Extract is often combined with Coleus forskohlii (a source of forskolin) by neurohackers

[1]N. Ceccarelli, M. Curadi, P. Picciarelli, L. Martelloni, C. Sbrana, M. Giovannetti, Med. J. Nutrition Metab. 3 (2010) 197–201.
[2]M. Ben Salem, H. Affes, K. Ksouda, R. Dhouibi, Z. Sahnoun, S. Hammami, K.M. Zeghal, Plant Foods Hum. Nutr. 70 (2015) 441–453.
[3]K. Kraft, Phytomedicine 4 (1997) 369–378.
[4]W. Englisch, C. Beckers, M. Unkauf, M. Ruepp, V. Zinserling, Arzneimittelforschung 50 (2000) 260–265.
[5]S. Grande, P. Bogani, A. de Saizieu, G. Schueler, C. Galli, F. Visioli, J. Agric. Food Chem. 52 (2004) 5021–5026.
[6]N. Xia, A. Pautz, U. Wollscheid, G. Reifenberg, U. Förstermann, H. Li, Molecules 19 (2014) 3654–3668.
[7]I. D’Antuono, A. Carola, L.M. Sena, V. Linsalata, A. Cardinali, A.F. Logrieco, M.G. Colucci, F. Apone, Molecules 23 (2018).
[8]H. Li, N. Xia, I. Brausch, Y. Yao, U. Förstermann, J. Pharmacol. Exp. Ther. 310 (2004) 926–932.
[9]G. Lupattelli, S. Marchesi, R. Lombardini, A.R. Roscini, F. Trinca, F. Gemelli, G. Vaudo, E. Mannarino, Life Sci. 76 (2004) 775–782.
[10]D. Zapolska-Downar, A. Zapolski-Downar, M. Naruszewicz, A. Siennicka, B. Krasnodebska, B. Kołdziej, Life Sci. 71 (2002) 2897–2808.
[11]R. Bundy, A.F. Walker, R.W. Middleton, C. Wallis, H.C.R. Simpson, Phytomedicine 15 (2008) 668–675.
[12]Z. Qiang, S.-O. Lee, Z. Ye, X. Wu, S. Hendrich, Phytother. Res. 26 (2012) 1048–1052.
[13]M. Rondanelli, A. Giacosa, A. Opizzi, M.A. Faliva, P. Sala, S. Perna, A. Riva, P. Morazzoni, E. Bombardelli, Int. J. Food Sci. Nutr. 64 (2013) 7–15.
[14]M. Rondanelli, A. Riva, G. Petrangolini, P. Allegrini, L. Bernardinelli, T. Fazia, G. Peroni, C. Gasparri, M. Nichetti, M.A. Faliva, M. Naso, S. Perna, Nutrients 12 (2020).
[15]Y. Panahi, P. Kianpour, R. Mohtashami, S.L. Atkin, A.E. Butler, R. Jafari, R. Badeli, A. Sahebkar, Phytother. Res. 32 (2018) 1382–1387.
[16]A. Skarpañska-Stejnborn, L. Pilaczynska-Szczesniak, P. Basta, E. Deskur-Smielecka, M. Horoszkiewicz-Hassan, Int. J. Sport Nutr. Exerc. Metab. 18 (2008) 313–327.
[17]J.E. Brown, C.A. Rice-Evans, Free Radic. Res. 29 (1998) 247–255.
[18]T. Nomikos, P. Detopoulou, E. Fragopoulou, E. Pliakis, S. Antonopoulou, Nutr. Res. 27 (2007) 741–749.
[19]N. Fantini, G. Colombo, A. Giori, A. Riva, P. Morazzoni, E. Bombardelli, M.A.M. Carai, Phytother. Res. 25 (2011) 463–466.
[20]M. Ebrahimi-Mameghani, M. Asghari-Jafarabadi, K. Rezazadeh, J. Integr. Med. 16 (2018) 329–334.
[21]M.-C. Yu, J.-H. Chen, C.-Y. Lai, C.-Y. Han, W.-C. Ko, Eur. J. Pharmacol. 627 (2010) 269–275.