Coffeeberry® (caffeine)

COFFEEBERRY® COMMON NAME

Coffee Fruit | Coffee Cherry | Coffee Berry

TOP BENEFITS OF COFFEEBERRY®

  • Supports cognitive performance*
  • Supports exercise performance*
  • Supports mood*

WHAT IS COFFEEBERRY®?

Coffeeberry® is made from organic coffee fruits, which are often called coffee cherries. Like cherries, coffee plants produce soft red fruits surrounding a pit or hard seed. The seed (or coffee “bean”) is roasted to make coffee. But it’s the fruit that is being used to make Coffeeberry®. Similar to many fruits, coffee cherries are high in polyphenols. And like coffee beans, they also contain caffeine. There are more than 120 Coffea species. The most popular species is Coffea arabica (commonly known simply as "Arabica"). Coffeeberry® is from Arabica coffee plants grown on sustainable farms. The fruits are handpicked when they are ripe. The caffeine we get in a morning coffee, a cup of tea, or an energy drink can help us perform better physically and mentally.* It does this by promoting arousal (wakefulness), which is a necessary ingredient for being able to pay attention and react quickly. Not surprisingly, this has led to caffeine being one of the most widely used and studied substances for both sports performance and brain function. While caffeine gets most of the attention, coffee polyphenols support healthy function. Most nootropics use pure caffeine; a better approach is using a coffee extract that gives caffeine and the naturally occurring coffee fruit polyphenols. 

NEUROHACKER’S COFFEEBERRY® SOURCING

Coffeeberry® organic whole coffee fruit extract is produced by Futureceuticals, a leader in fruit and vegetable extracts. 

Futureceuticals calls this ingredient CoffeeBerry® Energy, because it contains a minimum of 70% caffeine, along with polyphenols from coffee cherries. 

Made from carefully selected, hand-picked, premium Arabica coffee cherries. 

Sustainably sourced from farms certified Fairtrade International & Rainforest Alliance.

Coffeeberry® is GRAS, Non-GMO Project Verified, gluten-free, vegan, Kosher, organic, and eco-friendly. 

COFFEEBERRY® DOSING PRINCIPLES AND RATIONALE

Because of its content of caffeine, we consider Coffeeberry® Energy to follow hormetic dosing principles (see Neurohacker Dosing Principles) and to have a hormetic range (i.e., a dosing range below and above which results would be poorer). Caffeine is one of the most used, and best studied nootropic and ergogenic compounds. When used as a nootropic (i.e., to promote alertness, focus, reaction time, etc.) caffeine is typically dosed from 50 to 200 mg. When used as an ergogenic (i.e., for sports performance) just prior to exercise the upper end of the dose range can be as high as 600 mg.[1] In both of these cases, responses to caffeine tend to follow an adaptational (i.e., hormetic) curve, with low-to-moderate doses of caffeine supporting better cognitive and sports performance, but doses above the higher end of the range hindering performance. We have selected to dose Coffeeberry® at an amount that delivers the amount of caffeine (~90 mg) found in a small cup of coffee. This is in the middle of the range for nootropic purposes and on the lower end of what’s used for ergogenic purposes.

COFFEEBERRY® KEY MECHANISMS

Brain function

  • Adenosine receptor antagonist [2]
  • Adenosine decreases the levels of the neurotransmitters acetylcholine, glutamate, serotonin, dopamine and norepinephrine; blocking adenosine receptors, caffeine counters those effects [3,4]
  • Upregulates acetylcholine signaling [4–7]
  • Upregulates dopamine signaling [4,8–13]
  • Upregulates serotonin signaling [4,7,14–17]
  • Upregulates glutamate signaling [4,8,9]
  • Upregulates GABA signaling [4,7]
  • Upregulates noradrenaline signaling [4,16]
  • Upregulates cortical activation in the brain [2,4]
  • Upregulates cerebral metabolism [2,4]
  • Promotes wakefulness [18]

Cognitive function

  • Supports cognitive performance [1,4,19–22]
  • Supports executive function [23–25]
  • Supports information processing rate [2,26,27]
  • Supports simple and sustained attention [1,23,27,28]
  • Supports vigilance [1,28]
  • Supports task switching [27]
  • Supports reaction time [1,21,22,27]
  • Supports reasoning [20]
  • Supports creative thinking [24]
  • Protects from mental fatigue [26,28]

Neuroprotection

  • Protects against neurotoxic agents [29]
  • Protects from neurodegenerative processes [30]

Mood

  • Improves mood [4,21,22,25,31]

Physical performance

  • Protects from physical fatigue [19,22,23,32]
  • Decreases perceived exhaustion [1]
  • Supports muscle endurance and strength exercise activities [1]
  • Enhances speed, power, and agility during intense exercise [1] 

Other effects

  • Upregulates the metabolic rate [33–35]
  • Non-selective phosphodiesterase inhibitor [36]

Synergies

  • Theobromine as a CNS stimulant, with faster onset and shorter duration than Theobromine [37]
  • L-Theanine in cognitive performance [26,38–40]
  • Choline donors (e.g., citicoline, alpha-GPC) to support attention, concentration, and working memory [41]
  • L-ornithine to support enhanced mood and cognitive performance [42]


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