Beat Aging. Meet Our Newest Formula!

Sensoril® Ashwagandha Withania somnifera Root and Leaf Extract

Withania somnifera Common Name

Ashwagandha | Indian ginseng

Top Benefits of Withania somnifera

  • Supports healthy aging* 
  • Supports energy*
  • Supports a healthy stress response*
  • Supports exercise performance*
  • Supports healthy weight* 
  • Supports healthy metabolism*  
  • Supports mitochondrial structure and function* 
  • Supports antioxidant defenses* 
  • Supports brain function and mental cognition* 
  • Supports thyroid function*  
  • Supports healthy joint function*
  • Supports blood sugar balance*
  • Supports sleep*

What is Withania somnifera?

Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.

Neurohacker’s Withania somnifera Sourcing

Sensoril® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.

Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.

Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).

Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status). 

Vegetarian ● Organic compliant or certified organic ● Non-GMO Allergen & Gluten-free ● Kosher & Halal certified

Withania somnifera Dosing Principles and Rationale

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold  response in a study that gave different daily dosages—125 mg, 250 mg, 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose. 1 We opted for this lower dose to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.

Withania somnifera Key Mechanisms 

Mitochondrial structure and function

  • Supports mitochondrial membrane potential and structural integrity 2
  • Protects from mitochondrial damage 2
  • Protects from mitochondrial membrane permeabilization 3
  • Protects from complex I-V Inhibition (protects electron transport chain and oxidative phosphorylation performance) 2,4–6
  • Upregulates citric acid cycle enzymes 6

Improves exercise performance (ergogenic effect)

  • Supports endurance performance 7,8
  • Supports muscle strength 9,10
  • Supports post-exercise recovery 10

Metabolism

  • Supports healthy insulin sensitivity 11–15
  • Supports healthy blood glucose levels 12–16
  • Supports healthy leptin signaling 11,15

Body weight 

  • Supports healthy body weight 11,15
  • Supports healthy feeding behaviors 11,17
  • Upregulates lean mass 10

Antioxidant defenses

  • Upregulates antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]) 2,4,5,16,18
  • Replenishes glutathione (GSH) levels 2,4,16
  • Downregulates oxidative stress and reactive oxygen species levels 2–4,19

Cellular signaling 

  • Downregulates the expression of proinflammatory cytokines – tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL-1β), and IL-6 11–13

Brain function

  • Supports cognitive and psychomotor performance 20,21
  • Supports memory, executive function, attention, and information processing speed 22
  • Neuroprotective – protects from neuronal mitochondrial swelling and apoptosis; protects cognitive function (ischemia, oxidative stress) 2
  • Protects from neurotoxicity 4,5
  • Downregulates the basal activity levels of acetylcholine esterase 4
  • Upregulates dopamine levels 4
  • Supports mood 11
  • Regulates neural cytokine signaling 11
  • Supports quality of sleep 9

Thyroid function

  • Supports thyroid function 23–25

Stress response

  • Supports stress management 1,17,26
  • Downregulates serum cortisol levels 1,17,26
  • Downregulates endoplasmic reticulum (ER) stress 15

Healthy aging and longevity 

  • Lifespan extension effects (Caenorhabditis elegans) 19,27
  • Upregulates insulin-like growth factor-1 (IGF-1) signaling pathway 19,27
  • Downregulates α-synuclein and amyloid-β aggregation 19
  • Upregulates FOXO3A and SIRT3 28


REFERENCES

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3. Parihar P, et al. Cell Mol Biol . 2016;62(1):73-83. PMID: 26828992.
4. Manjunath MJ, Muralidhara. J Food Sci Technol. 2015;52(4):1971-1981. doi:10.1007/s13197-013-1219-0
5. Kumar P, Kumar A. J Med Food. 2009;12(3):591-600. doi:10.1089/jmf.2008.0028
6. Senthilnathan P, et al. Life Sci. 2006;78(9):1010-1014. doi:10.1016/j.lfs.2005.06.005
7. Sandhu JS, et al. Int J Ayurveda Res. 2010;1(3):144-149. doi:10.4103/0974-7788.72485
8. Choudhary B, et al. Ayu. 2015;36(1):63-68. doi:10.4103/0974-8520.169002
9. Raut AA, et al. J Ayurveda Integr Med. 2012;3(3):111-114. doi:10.4103/0975-9476.100168
10. Wankhede S, et al. J Int Soc Sports Nutr. 2015;12:43. doi:10.1186/s12970-015-0104-9
11. Kaur T, Kaur G. J Neuroinflammation. 2017;14(1):201. doi:10.1186/s12974-017-0975-6
12. Shahraki MR, et al. J Basic Clin Physiol Pharmacol. 2016;27(4):387-391. doi:10.1515/jbcpp-2015-0053
13. Samadi Noshahr Z, et al. Rep Biochem Mol Biol. 2015;3(2):62-67. PMID: 26989739.
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16. Anwer T, et al. Acta Pol Pharm. 2012;69(6):1095-1101. PMID: 23285670.
17. Choudhary D, et al. J Evid Based Complem Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830
18. Gupta SK, et al. Drug Metabol Drug Interact. 2003;19(3):211-222. PMID: 14682611.
19. Akhoon BA, et al. Exp Gerontol. 2016;78:47-56. doi:10.1016/j.exger.2016.03.004
20. Pingali U, et al. Pharmacognosy Res. 2014;6(1):12-18. doi:10.4103/0974-8490.122912
21. Chengappa KNR, et al. J Clin Psychiatry. 2013;74(11):1076-1083. doi:10.4088/JCP.13m08413
22. Choudhary D, et al. J Diet Suppl. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970
23. Sharma AK, et al. J Altern Complement Med. 2018;24(3):243-248. doi:10.1089/acm.2017.0183
24. Gannon JM, et al. J Ayurveda Integr Med. 2014;5(4):241-245. doi:10.4103/0975-9476.146566
25. Jatwa R, Kar A. Phytother Res. 2009;23(8):1140-1145. doi:10.1002/ptr.2765
26. Chandrasekhar K, et al. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022
27. Akhoon BA, et al. Exp Gerontol. 2018;104:113-117. doi:10.1016/j.exger.2018.02.004
28. Pradhan R, et al. Exp Gerontol. 2017;95:9-15. doi:10.1016/j.exger.2017.05.013