Ashwagandha | Indian ginseng
Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.
Sensoril® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.
Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.
Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).
Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status).
Vegetarian ● Organic compliant or certified organic ● Non-GMO Allergen & Gluten-free ● Kosher & Halal certified
We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold response in a study that gave different daily dosages—125 mg, 250 mg, 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose. 1 We opted for this lower dose to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.
Mitochondrial structure and function
Improves exercise performance (ergogenic effect)
Metabolism
Body weight
Antioxidant defenses
Cellular signaling
Brain function
Thyroid function
Stress response
Healthy aging and longevity
REFERENCES
1. Auddy B, et al. Journal of American Nutraceutical Association. 2008;11:50-56.
2. Sood A, et al. Metab Brain Dis. 2018;33(4):1261-1274. doi:10.1007/s11011-018-0234-2
3. Parihar P, et al. Cell Mol Biol . 2016;62(1):73-83. PMID: 26828992.
4. Manjunath MJ, Muralidhara. J Food Sci Technol. 2015;52(4):1971-1981. doi:10.1007/s13197-013-1219-0
5. Kumar P, Kumar A. J Med Food. 2009;12(3):591-600. doi:10.1089/jmf.2008.0028
6. Senthilnathan P, et al. Life Sci. 2006;78(9):1010-1014. doi:10.1016/j.lfs.2005.06.005
7. Sandhu JS, et al. Int J Ayurveda Res. 2010;1(3):144-149. doi:10.4103/0974-7788.72485
8. Choudhary B, et al. Ayu. 2015;36(1):63-68. doi:10.4103/0974-8520.169002
9. Raut AA, et al. J Ayurveda Integr Med. 2012;3(3):111-114. doi:10.4103/0975-9476.100168
10. Wankhede S, et al. J Int Soc Sports Nutr. 2015;12:43. doi:10.1186/s12970-015-0104-9
11. Kaur T, Kaur G. J Neuroinflammation. 2017;14(1):201. doi:10.1186/s12974-017-0975-6
12. Shahraki MR, et al. J Basic Clin Physiol Pharmacol. 2016;27(4):387-391. doi:10.1515/jbcpp-2015-0053
13. Samadi Noshahr Z, et al. Rep Biochem Mol Biol. 2015;3(2):62-67. PMID: 26989739.
14. Anwer T, et al. Basic Clin Pharmacol Toxicol. 2008;102(6):498-503. doi:10.1111/j.1742-7843.2008.00223.x
15. Lee J, et al. Nat Med. 2016;22(9):1023-1032. doi:10.1038/nm.4145
16. Anwer T, et al. Acta Pol Pharm. 2012;69(6):1095-1101. PMID: 23285670.
17. Choudhary D, et al. J Evid Based Complem Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830
18. Gupta SK, et al. Drug Metabol Drug Interact. 2003;19(3):211-222. PMID: 14682611.
19. Akhoon BA, et al. Exp Gerontol. 2016;78:47-56. doi:10.1016/j.exger.2016.03.004
20. Pingali U, et al. Pharmacognosy Res. 2014;6(1):12-18. doi:10.4103/0974-8490.122912
21. Chengappa KNR, et al. J Clin Psychiatry. 2013;74(11):1076-1083. doi:10.4088/JCP.13m08413
22. Choudhary D, et al. J Diet Suppl. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970
23. Sharma AK, et al. J Altern Complement Med. 2018;24(3):243-248. doi:10.1089/acm.2017.0183
24. Gannon JM, et al. J Ayurveda Integr Med. 2014;5(4):241-245. doi:10.4103/0975-9476.146566
25. Jatwa R, Kar A. Phytother Res. 2009;23(8):1140-1145. doi:10.1002/ptr.2765
26. Chandrasekhar K, et al. Indian J Psychol Med. 2012;34(3):255-262. doi:10.4103/0253-7176.106022
27. Akhoon BA, et al. Exp Gerontol. 2018;104:113-117. doi:10.1016/j.exger.2018.02.004
28. Pradhan R, et al. Exp Gerontol. 2017;95:9-15. doi:10.1016/j.exger.2017.05.013