Pantothenate | Pantothenic acid | Vitamin B5
Pantothenic acid (vitamin B5) is part of the B complex—a group of water-soluble vitamins that play important roles in cellular metabolism and energy production. It is an essential vitamin and the precursor of Coenzyme A (CoA), a molecule that is ubiquitous in the human body and that participates in the key metabolic pathways for cellular energy generation. CoA is also used in the synthesis of the neurotransmitter acetylcholine and is therefore essential for proper nervous system function.
Calcium pantothenate—the calcium salt of pantothenic acid—is used in dietary supplements, because it’s more stable than pantothenic acid.
Calcium pantothenate sourcing is focused on identifying and purchasing from a reputable supplier and ensuring it’s NON-GMO, gluten-free and vegan.
Vitamin B5 generally has a wide dosing range, however, we consider it to be subject to a dosing threshold (see Neurohacker Dosing Principles), which means, while more might be better within a range, increasing amounts beyond that is very high amounts would be unlikely to add significant additional nutritional or functional benefits for most people. Our goal in formulating products is to make sure that pantothenic acid amounts will be within this threshold range, even if several of our products with vitamin B5 are used together. In general, we tend to dose vitamin B5 at higher amounts in formulations where it would be used to support neurotransmitter production, and lower levels when we are using it to compliment a full B complex stack.
 A. G. Tahiliani, C. J. Beinlich, in Vitamins & Hormones, G. D. Aurbach, Ed. (Academic Press, 1991), vol. 46, pp. 165–228.
 R. Leonardi, Y.-M. Zhang, C. O. Rock, S. Jackowski, Prog. Lipid Res. 44, 125–153 (2005).
 F. Pietrocola, L. Galluzzi, J. M. Bravo-San Pedro, F. Madeo, G. Kroemer, Cell Metab. 21, 805–821 (2015).
 S. K. Fisher, S. Wonnacott, in Basic Neurochemistry (Eighth Edition), S. T. Brady, G. J. Siegel, R. W. Albers, D. L. Price, Eds. (Academic Press, New York, 2012), pp. 258–282.